E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.148 -9999.0 0.0 -0.431 42.0 42.0 KLHL20 0.042 0.115 0.308 40.0 -0.259 14.0 54.0 CYFIP2 0.05 0.048 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.003 0.117 0.338 4.0 -0.348 6.0 10.0 ENAH -0.031 0.143 -9999.0 0.0 -0.43 37.0 37.0 AP1M1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.051 -9999.0 0.0 -0.541 4.0 4.0 CDC42/GTP 0.009 0.075 -9999.0 0.0 -0.29 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.04 -9999.0 0.0 -0.178 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.095 -9999.0 0.0 -0.31 26.0 26.0 RAPGEF1 -0.029 0.142 0.336 1.0 -0.403 37.0 38.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.031 0.164 -9999.0 0.0 -0.438 51.0 51.0 CRK -0.027 0.145 0.347 1.0 -0.429 39.0 40.0 E-cadherin/gamma catenin/alpha catenin 0.037 0.089 -9999.0 0.0 -0.342 21.0 21.0 alphaE/beta7 Integrin 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.055 0.042 -9999.0 0.0 -0.309 3.0 3.0 DLG1 -0.04 0.158 -9999.0 0.0 -0.432 49.0 49.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.021 0.061 -9999.0 0.0 -0.206 10.0 10.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.541 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.058 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.022 0.081 -9999.0 0.0 -0.273 8.0 8.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.095 -9999.0 0.0 -0.315 33.0 33.0 TIAM1 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.047 0.089 -9999.0 0.0 -0.292 26.0 26.0 AKT1 -0.007 0.056 -9999.0 0.0 -0.197 1.0 1.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.541 47.0 47.0 CDH1 0.007 0.118 -9999.0 0.0 -0.541 22.0 22.0 RhoA/GDP 0.001 0.117 0.326 4.0 -0.349 6.0 10.0 actin cytoskeleton organization 0.037 0.093 0.256 43.0 -0.188 13.0 56.0 CDC42/GDP 0.0 0.116 0.337 3.0 -0.346 6.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.004 0.066 -9999.0 0.0 -0.251 24.0 24.0 ITGB7 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.095 -9999.0 0.0 -0.31 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.032 0.082 -9999.0 0.0 -0.289 26.0 26.0 mol:GDP -0.018 0.124 0.332 4.0 -0.347 25.0 29.0 CDC42/GTP/IQGAP1 0.043 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.008 0.12 0.342 3.0 -0.368 5.0 8.0 RAC1/GTP/IQGAP1 0.044 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.068 0.204 26.0 -0.225 11.0 37.0 NME1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.037 0.157 -9999.0 0.0 -0.439 47.0 47.0 regulation of cell-cell adhesion -0.001 0.061 -9999.0 0.0 -0.254 2.0 2.0 WASF2 0.02 0.043 0.119 33.0 -0.119 2.0 35.0 Rap1/GTP 0.012 0.087 0.282 1.0 -0.326 2.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.092 -9999.0 0.0 -0.298 21.0 21.0 CCND1 0.017 0.08 0.239 23.0 -0.282 11.0 34.0 VAV2 -0.019 0.193 0.391 3.0 -0.514 40.0 43.0 RAP1/GDP 0.011 0.101 0.312 3.0 -0.348 4.0 7.0 adherens junction assembly -0.034 0.154 -9999.0 0.0 -0.425 47.0 47.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.044 0.088 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/beta catenin -0.006 0.088 -9999.0 0.0 -0.335 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.157 -9999.0 0.0 -0.431 49.0 49.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.014 0.146 0.284 60.0 -0.424 17.0 77.0 E-cadherin/beta catenin/alpha catenin 0.036 0.095 -9999.0 0.0 -0.338 26.0 26.0 ITGAE 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.032 0.167 -9999.0 0.0 -0.448 51.0 51.0