Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.237 0.594 2.0 -0.556 74.0 76.0 IHH 0.021 0.075 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.313 128.0 128.0 LRPAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.067 0.147 0.311 128.0 -9999.0 0.0 128.0 SMO/beta Arrestin2 -0.001 0.185 0.413 2.0 -0.55 15.0 17.0 SMO -0.016 0.184 0.445 2.0 -0.511 27.0 29.0 AKT1 -0.02 0.191 -9999.0 0.0 -0.6 36.0 36.0 ARRB2 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.237 -9999.0 0.0 -0.541 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.182 0.444 2.0 -0.503 27.0 29.0 STIL 0.041 0.149 0.389 16.0 -0.366 4.0 20.0 DHH N/PTCH2 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.162 0.38 2.0 -0.435 23.0 25.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.392 0.524 6.0 -0.901 94.0 100.0 determination of left/right symmetry -0.015 0.182 0.444 2.0 -0.503 27.0 29.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.541 47.0 47.0 skeletal system development -0.109 0.387 0.523 6.0 -0.889 94.0 100.0 IHH N/Hhip 0.038 0.053 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.182 0.444 2.0 -0.503 27.0 29.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.059 -9999.0 0.0 -0.541 5.0 5.0 PI3K 0.006 0.127 -9999.0 0.0 -0.379 48.0 48.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.143 0.266 -9999.0 0.0 -0.541 158.0 158.0 somite specification -0.015 0.182 0.444 2.0 -0.503 27.0 29.0 SHH Np/Cholesterol/PTCH1 -0.009 0.122 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.31 5.0 5.0 SHH Np/Cholesterol/Megalin -0.055 0.144 -9999.0 0.0 -0.319 110.0 110.0 SHH 0.011 0.043 -9999.0 0.0 -0.398 5.0 5.0 catabolic process -0.009 0.174 0.468 2.0 -0.481 23.0 25.0 SMO/Vitamin D3 0.01 0.171 0.41 15.0 -0.463 12.0 27.0 SHH Np/Cholesterol/Hhip 0.025 0.038 -9999.0 0.0 -0.31 5.0 5.0 LRP2 -0.119 0.254 -9999.0 0.0 -0.541 136.0 136.0 receptor-mediated endocytosis -0.061 0.195 0.349 8.0 -0.513 37.0 45.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.311 87.0 87.0 SHH Np/Cholesterol/CDO 0.02 0.049 -9999.0 0.0 -0.35 7.0 7.0 mesenchymal cell differentiation -0.025 0.038 0.308 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.026 0.158 0.415 16.0 -0.402 6.0 22.0 IHH N/PTCH2 0.038 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.541 3.0 3.0 IHH N/PTCH1 -0.0 0.179 0.471 2.0 -0.485 23.0 25.0 Megalin/LRPAP1 -0.07 0.197 -9999.0 0.0 -0.396 137.0 137.0 PTCH2 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.308 5.0 5.0 PTCH1 -0.009 0.175 0.469 2.0 -0.483 23.0 25.0 HHIP 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0