Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.091 -9999.0 0.0 -0.256 46.0 46.0 epithelial cell differentiation 0.04 0.086 -9999.0 0.0 -0.289 26.0 26.0 CYFIP2 0.05 0.048 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.009 0.07 0.283 5.0 -0.319 1.0 6.0 EGFR -0.268 0.287 -9999.0 0.0 -0.541 269.0 269.0 EPHA2 0.026 0.062 -9999.0 0.0 -0.541 6.0 6.0 MYO6 0.001 0.074 -9999.0 0.0 -0.283 25.0 25.0 CTNNB1 0.029 0.051 -9999.0 0.0 -0.541 4.0 4.0 ABI1/Sra1/Nap1 0.074 0.036 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.14 0.236 -9999.0 0.0 -0.487 151.0 151.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.072 -9999.0 0.0 -0.279 25.0 25.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.105 -9999.0 0.0 -0.287 63.0 63.0 EGF -0.148 0.269 -9999.0 0.0 -0.541 163.0 163.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.052 0.18 -9999.0 0.0 -0.491 62.0 62.0 cortical microtubule organization 0.04 0.086 -9999.0 0.0 -0.289 26.0 26.0 GO:0000145 -0.021 0.064 -9999.0 0.0 -0.266 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.089 -9999.0 0.0 -0.292 26.0 26.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.541 3.0 3.0 ARF6/GDP -0.03 0.058 -9999.0 0.0 -0.27 25.0 25.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.059 -9999.0 0.0 -0.314 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.069 -9999.0 0.0 -0.42 1.0 1.0 PVRL2 0.039 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.002 0.073 -9999.0 0.0 -0.283 26.0 26.0 ARF6/GTP 0.064 0.061 -9999.0 0.0 -0.295 6.0 6.0 CDH1 0.007 0.118 -9999.0 0.0 -0.541 22.0 22.0 EGFR/EGFR/EGF/EGF -0.228 0.204 -9999.0 0.0 -0.347 354.0 354.0 RhoA/GDP 0.041 0.084 -9999.0 0.0 -0.281 25.0 25.0 actin cytoskeleton organization -0.021 0.068 -9999.0 0.0 -0.278 24.0 24.0 IGF-1R heterotetramer 0.011 0.116 -9999.0 0.0 -0.54 21.0 21.0 GIT1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.116 -9999.0 0.0 -0.541 21.0 21.0 IGF1 -0.248 0.288 -9999.0 0.0 -0.541 252.0 252.0 DIAPH1 0.058 0.126 -9999.0 0.0 -0.555 8.0 8.0 Wnt receptor signaling pathway -0.04 0.086 0.289 26.0 -9999.0 0.0 26.0 RHOA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.059 -9999.0 0.0 -0.274 20.0 20.0 CTNNA1 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.069 -9999.0 0.0 -0.283 25.0 25.0 EFNA1 0.028 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.066 -9999.0 0.0 -0.273 25.0 25.0 Ephrin A1/EPHA2 0.023 0.083 -9999.0 0.0 -0.288 26.0 26.0 SEC6/SEC8 -0.007 0.068 -9999.0 0.0 -0.27 26.0 26.0 MGAT3 -0.024 0.106 -9999.0 0.0 -0.292 63.0 63.0 HGF/MET 0.004 0.126 -9999.0 0.0 -0.289 73.0 73.0 HGF 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.011 0.092 -9999.0 0.0 -0.258 46.0 46.0 actin cable formation 0.053 0.107 0.366 12.0 -0.288 1.0 13.0 KIAA1543 -0.021 0.065 -9999.0 0.0 -0.27 25.0 25.0 KIFC3 0.001 0.07 -9999.0 0.0 -0.283 25.0 25.0 NCK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.001 0.072 -9999.0 0.0 -0.283 25.0 25.0 NCK1/GIT1 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.04 0.086 -9999.0 0.0 -0.289 26.0 26.0 EXOC4 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.071 -9999.0 0.0 -0.283 25.0 25.0 PIP5K1C -0.001 0.073 -9999.0 0.0 -0.283 25.0 25.0 LIMA1 0.013 0.109 -9999.0 0.0 -0.541 19.0 19.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.012 0.101 0.304 11.0 -0.341 2.0 13.0 adherens junction assembly -0.031 0.132 0.298 1.0 -0.615 14.0 15.0 IGF-1R heterotetramer/IGF1 -0.13 0.183 -9999.0 0.0 -0.304 248.0 248.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.045 0.049 -9999.0 0.0 -0.398 3.0 3.0 MET -0.022 0.171 -9999.0 0.0 -0.541 50.0 50.0 PLEKHA7 -0.001 0.072 -9999.0 0.0 -0.283 25.0 25.0 mol:GTP 0.056 0.058 -9999.0 0.0 -0.312 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.012 0.087 0.362 5.0 -0.35 1.0 6.0 cortical actin cytoskeleton stabilization -0.01 0.091 -9999.0 0.0 -0.256 46.0 46.0 regulation of cell-cell adhesion -0.021 0.068 -9999.0 0.0 -0.278 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.011 0.092 -9999.0 0.0 -0.258 46.0 46.0