Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.204 0.32 -9999.0 0.0 -0.698 41.0 41.0 IHH -0.106 0.203 -9999.0 0.0 -0.564 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.07 0.17 -9999.0 0.0 -0.359 44.0 44.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.07 0.169 0.356 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.141 0.232 -9999.0 0.0 -0.608 25.0 25.0 SMO -0.155 0.245 -9999.0 0.0 -0.648 25.0 25.0 AKT1 -0.063 0.131 -9999.0 0.0 -0.688 3.0 3.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.043 0.169 -9999.0 0.0 -0.557 18.0 18.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.153 0.24 -9999.0 0.0 -0.635 25.0 25.0 STIL -0.129 0.227 -9999.0 0.0 -0.61 23.0 23.0 DHH N/PTCH2 -0.027 0.141 -9999.0 0.0 -0.447 18.0 18.0 DHH N/PTCH1 -0.125 0.211 -9999.0 0.0 -0.589 21.0 21.0 PIK3CA 0.009 0.047 -9999.0 0.0 -0.626 1.0 1.0 DHH -0.012 0.117 -9999.0 0.0 -0.601 7.0 7.0 PTHLH -0.277 0.429 -9999.0 0.0 -0.972 41.0 41.0 determination of left/right symmetry -0.153 0.24 -9999.0 0.0 -0.635 25.0 25.0 PIK3R1 -0.013 0.119 -9999.0 0.0 -0.57 8.0 8.0 skeletal system development -0.273 0.421 -9999.0 0.0 -0.955 41.0 41.0 IHH N/Hhip -0.097 0.199 -9999.0 0.0 -0.459 39.0 39.0 DHH N/Hhip -0.046 0.16 -9999.0 0.0 -0.437 25.0 25.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.153 0.24 -9999.0 0.0 -0.635 25.0 25.0 pancreas development -0.053 0.173 -9999.0 0.0 -0.536 21.0 21.0 HHAT -0.001 0.093 -9999.0 0.0 -0.626 4.0 4.0 PI3K -0.002 0.094 -9999.0 0.0 -0.416 9.0 9.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.049 0.182 -9999.0 0.0 -0.584 19.0 19.0 somite specification -0.153 0.24 -9999.0 0.0 -0.635 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.143 0.24 -9999.0 0.0 -0.586 31.0 31.0 SHH Np/Cholesterol/PTCH2 -0.058 0.154 -9999.0 0.0 -0.347 39.0 39.0 SHH Np/Cholesterol/Megalin -0.074 0.163 -9999.0 0.0 -0.343 46.0 46.0 SHH -0.055 0.16 -9999.0 0.0 -0.411 31.0 31.0 catabolic process -0.132 0.22 -9999.0 0.0 -0.63 19.0 19.0 SMO/Vitamin D3 -0.158 0.248 -9999.0 0.0 -0.633 28.0 28.0 SHH Np/Cholesterol/Hhip -0.074 0.17 -9999.0 0.0 -0.366 43.0 43.0 LRP2 -0.052 0.175 -9999.0 0.0 -0.541 21.0 21.0 receptor-mediated endocytosis -0.17 0.236 -9999.0 0.0 -0.672 22.0 22.0 SHH Np/Cholesterol/BOC -0.067 0.15 -9999.0 0.0 -0.315 48.0 48.0 SHH Np/Cholesterol/CDO -0.041 0.134 -9999.0 0.0 -0.323 33.0 33.0 mesenchymal cell differentiation 0.074 0.168 0.364 43.0 -9999.0 0.0 43.0 mol:Vitamin D3 -0.142 0.242 -9999.0 0.0 -0.589 31.0 31.0 IHH N/PTCH2 -0.078 0.177 -9999.0 0.0 -0.412 36.0 36.0 CDON 0.003 0.077 -9999.0 0.0 -0.596 3.0 3.0 IHH N/PTCH1 -0.133 0.223 -9999.0 0.0 -0.637 19.0 19.0 Megalin/LRPAP1 -0.029 0.128 -9999.0 0.0 -0.386 21.0 21.0 PTCH2 -0.026 0.147 -9999.0 0.0 -0.582 12.0 12.0 SHH Np/Cholesterol -0.05 0.121 -9999.0 0.0 -0.319 31.0 31.0 PTCH1 -0.133 0.221 -9999.0 0.0 -0.633 19.0 19.0 HHIP -0.053 0.173 -9999.0 0.0 -0.537 21.0 21.0