Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	34.0	2069.0	60.0	-0.658	0.013	1000.0	-1000.0	-0.179	-1000.0
HIF-1-alpha transcription factor network	30.0	2309.0	76.0	-0.594	0.02	1000.0	-1000.0	-0.174	-1000.0
p75(NTR)-mediated signaling	26.0	3286.0	125.0	-0.245	0.034	1000.0	-1000.0	-0.098	-1000.0
IL4-mediated signaling events	26.0	2414.0	91.0	-0.82	0.685	1000.0	-1000.0	-0.16	-1000.0
Signaling mediated by p38-alpha and p38-beta	26.0	1176.0	44.0	-0.231	0.013	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by the Hedgehog family	23.0	1202.0	52.0	-0.277	0.074	1000.0	-1000.0	-0.07	-1000.0
Syndecan-1-mediated signaling events	22.0	756.0	34.0	-0.176	0.013	1000.0	-1000.0	-0.053	-1000.0
Glypican 1 network	20.0	960.0	48.0	-0.156	0.02	1000.0	-1000.0	-0.035	-1000.0
FOXA2 and FOXA3 transcription factor networks	19.0	900.0	46.0	-0.398	0.019	1000.0	-1000.0	-0.102	-1000.0
BMP receptor signaling	19.0	1579.0	81.0	-0.254	0.026	1000.0	-1000.0	-0.093	-1000.0
IL12-mediated signaling events	18.0	1621.0	87.0	-0.325	0.102	1000.0	-1000.0	-0.13	-1000.0
Glucocorticoid receptor regulatory network	18.0	2138.0	114.0	-0.663	0.314	1000.0	-1000.0	-0.075	-1000.0
TCR signaling in naïve CD8+ T cells	17.0	1652.0	93.0	-0.164	0.088	1000.0	-1000.0	-0.09	-1000.0
Glypican 2 network	17.0	70.0	4.0	-0.056	-0.042	1000.0	-1000.0	-0.023	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	17.0	2083.0	120.0	-0.286	0.21	1000.0	-1000.0	-0.079	-1000.0
Endothelins	16.0	1544.0	96.0	-0.202	0.023	1000.0	-1000.0	-0.083	-1000.0
Wnt signaling	16.0	112.0	7.0	-0.093	0.009	1000.0	-1000.0	-0.032	-1000.0
Syndecan-2-mediated signaling events	15.0	1076.0	69.0	-0.129	0.017	1000.0	-1000.0	-0.039	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	15.0	1046.0	68.0	-0.317	0.068	1000.0	-1000.0	-0.138	-1000.0
BCR signaling pathway	15.0	1506.0	99.0	-0.179	0.028	1000.0	-1000.0	-0.093	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	497.0	34.0	-0.099	0.013	1000.0	-1000.0	-0.062	-1000.0
amb2 Integrin signaling	14.0	1196.0	82.0	-0.163	0.015	1000.0	-1000.0	-0.082	-1000.0
Effects of Botulinum toxin	14.0	373.0	26.0	-0.178	0.013	1000.0	-1000.0	-0.064	-1000.0
Syndecan-4-mediated signaling events	14.0	998.0	67.0	-0.158	0.021	1000.0	-1000.0	-0.088	-1000.0
IL27-mediated signaling events	13.0	663.0	51.0	-0.165	0.088	1000.0	-1000.0	-0.077	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1138.0	86.0	-0.103	0.07	1000.0	-1000.0	-0.081	-1000.0
Class IB PI3K non-lipid kinase events	13.0	39.0	3.0	-0.029	-1000.0	1000.0	-1000.0	-0.014	-1000.0
Ephrin A  reverse signaling	12.0	88.0	7.0	-0.021	-0.0	1000.0	-1000.0	-0.021	-1000.0
Thromboxane A2 receptor signaling	12.0	1288.0	105.0	-0.098	0.029	1000.0	-1000.0	-0.059	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1181.0	97.0	-0.135	0.03	1000.0	-1000.0	-0.082	-1000.0
Nectin adhesion pathway	12.0	813.0	63.0	-0.104	0.022	1000.0	-1000.0	-0.077	-1000.0
Signaling events regulated by Ret tyrosine kinase	12.0	994.0	82.0	-0.134	0.013	1000.0	-1000.0	-0.085	-1000.0
S1P5 pathway	12.0	205.0	17.0	-0.105	0.078	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	12.0	1082.0	84.0	-0.173	0.019	1000.0	-1000.0	-0.093	-1000.0
ErbB4 signaling events	11.0	773.0	69.0	-0.176	0.066	1000.0	-1000.0	-0.093	-1000.0
Reelin signaling pathway	11.0	634.0	56.0	-0.141	0.019	1000.0	-1000.0	-0.076	-1000.0
Ephrin B reverse signaling	11.0	551.0	48.0	-0.108	0.062	1000.0	-1000.0	-0.075	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	360.0	31.0	-0.229	0.013	1000.0	-1000.0	-0.09	-1000.0
LPA receptor mediated events	11.0	1149.0	102.0	-0.123	0.022	1000.0	-1000.0	-0.09	-1000.0
IL6-mediated signaling events	11.0	834.0	75.0	-0.151	0.045	1000.0	-1000.0	-0.088	-1000.0
Caspase cascade in apoptosis	10.0	759.0	74.0	-0.091	0.032	1000.0	-1000.0	-0.044	-1000.0
Coregulation of Androgen receptor activity	10.0	797.0	76.0	-0.19	0.024	1000.0	-1000.0	-0.036	-1000.0
Noncanonical Wnt signaling pathway	10.0	265.0	26.0	-0.093	0.013	1000.0	-1000.0	-0.058	-1000.0
Arf6 signaling events	10.0	668.0	62.0	-0.106	0.016	1000.0	-1000.0	-0.059	-1000.0
PDGFR-alpha signaling pathway	10.0	448.0	44.0	-0.083	0.022	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	10.0	620.0	62.0	-0.174	0.058	1000.0	-1000.0	-0.094	-1000.0
TCGA08_retinoblastoma	10.0	85.0	8.0	-0.013	0.019	1000.0	-1000.0	-0.016	-1000.0
LPA4-mediated signaling events	9.0	115.0	12.0	-0.08	0.018	1000.0	-1000.0	-0.03	-1000.0
Osteopontin-mediated events	9.0	358.0	38.0	-0.107	0.013	1000.0	-1000.0	-0.102	-1000.0
Nongenotropic Androgen signaling	9.0	484.0	52.0	-0.098	0.016	1000.0	-1000.0	-0.059	-1000.0
EGFR-dependent Endothelin signaling events	9.0	193.0	21.0	-0.096	0.019	1000.0	-1000.0	-0.074	-1000.0
IGF1 pathway	9.0	560.0	57.0	-0.103	0.026	1000.0	-1000.0	-0.1	-1000.0
Visual signal transduction: Rods	9.0	482.0	52.0	-0.173	0.013	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by PTP1B	8.0	632.0	76.0	-0.177	0.021	1000.0	-1000.0	-0.089	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	504.0	61.0	-0.162	0.029	1000.0	-1000.0	-0.076	-1000.0
Canonical Wnt signaling pathway	8.0	452.0	51.0	-0.162	0.071	1000.0	-1000.0	-0.066	-1000.0
EPHB forward signaling	8.0	740.0	85.0	-0.116	0.09	1000.0	-1000.0	-0.102	-1000.0
Angiopoietin receptor Tie2-mediated signaling	8.0	725.0	88.0	-0.151	0.024	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	632.0	78.0	-0.077	0.041	1000.0	-1000.0	-0.083	-1000.0
Regulation of Androgen receptor activity	8.0	575.0	70.0	-0.292	0.026	1000.0	-1000.0	-0.069	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	206.0	28.0	-0.105	0.031	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Cones	7.0	270.0	38.0	-0.063	0.013	1000.0	-1000.0	-0.062	-1000.0
Cellular roles of Anthrax toxin	7.0	292.0	39.0	-0.072	0.014	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	471.0	65.0	-0.357	0.036	1000.0	-1000.0	-0.068	-1000.0
Syndecan-3-mediated signaling events	7.0	270.0	35.0	-0.171	0.034	1000.0	-1000.0	-0.054	-1000.0
S1P4 pathway	7.0	194.0	25.0	-0.105	0.019	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	6.0	374.0	57.0	-0.053	0.037	1000.0	-1000.0	-0.056	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	114.0	17.0	-0.033	0.016	1000.0	-1000.0	-0.045	-1000.0
TRAIL signaling pathway	6.0	302.0	48.0	-0.034	0.022	1000.0	-1000.0	-0.064	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	334.0	52.0	-0.092	0.032	1000.0	-1000.0	-0.054	-1000.0
S1P1 pathway	6.0	237.0	36.0	-0.101	0.013	1000.0	-1000.0	-0.056	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	95.0	15.0	-0.016	0.023	1000.0	-1000.0	-0.024	-1000.0
IL2 signaling events mediated by PI3K	6.0	358.0	58.0	-0.064	0.023	1000.0	-1000.0	-0.096	-1000.0
Regulation of Telomerase	6.0	619.0	102.0	-0.133	0.038	1000.0	-1000.0	-0.105	-1000.0
S1P3 pathway	6.0	260.0	42.0	-0.056	0.021	1000.0	-1000.0	-0.033	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	720.0	136.0	-0.16	0.062	1000.0	-1000.0	-0.074	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	275.0	54.0	-0.086	0.025	1000.0	-1000.0	-0.096	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	457.0	85.0	-0.048	0.018	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	5.0	357.0	68.0	-0.136	0.023	1000.0	-1000.0	-0.103	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	193.0	37.0	-0.052	0.021	1000.0	-1000.0	-0.057	-1000.0
FAS signaling pathway (CD95)	5.0	235.0	47.0	-0.085	0.015	1000.0	-1000.0	-0.049	-1000.0
Retinoic acid receptors-mediated signaling	5.0	318.0	58.0	-0.078	0.026	1000.0	-1000.0	-0.076	-1000.0
IL2 signaling events mediated by STAT5	5.0	120.0	22.0	-0.037	0.027	1000.0	-1000.0	-0.061	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	99.0	17.0	-0.024	0.022	1000.0	-1000.0	-0.05	-1000.0
ErbB2/ErbB3 signaling events	4.0	320.0	65.0	-0.124	0.022	1000.0	-1000.0	-0.064	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	24.0	5.0	-0.008	0.004	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by HDAC Class III	4.0	195.0	40.0	-0.17	0.02	1000.0	-1000.0	-0.046	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	211.0	45.0	-0.074	0.037	1000.0	-1000.0	-0.089	-1000.0
Class I PI3K signaling events	4.0	309.0	73.0	-0.077	0.028	1000.0	-1000.0	-0.075	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	147.0	33.0	-0.121	0.029	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	4.0	82.0	20.0	-0.039	0.015	1000.0	-1000.0	-0.021	-1000.0
p38 MAPK signaling pathway	4.0	179.0	44.0	-0.116	0.024	1000.0	-1000.0	-0.063	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.003	0.013	1000.0	-1000.0	-0.016	-1000.0
EPO signaling pathway	3.0	165.0	55.0	-0.027	0.047	1000.0	-1000.0	-0.087	-1000.0
Ceramide signaling pathway	3.0	291.0	76.0	-0.099	0.036	1000.0	-1000.0	-0.051	-1000.0
TCGA08_p53	3.0	23.0	7.0	-0.01	0.013	1000.0	-1000.0	-0.018	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	123.0	36.0	-0.052	0.027	1000.0	-1000.0	-0.071	-1000.0
Regulation of p38-alpha and p38-beta	3.0	185.0	54.0	-0.077	0.033	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	396.0	125.0	-0.076	0.047	1000.0	-1000.0	-0.095	-1000.0
TCGA08_rtk_signaling	3.0	93.0	26.0	-0.039	0.039	1000.0	-1000.0	-0.024	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	269.0	74.0	-0.192	0.061	1000.0	-1000.0	-0.094	-1000.0
Insulin Pathway	3.0	259.0	74.0	-0.151	0.026	1000.0	-1000.0	-0.093	-1000.0
VEGFR1 specific signals	3.0	170.0	56.0	-0.03	0.03	1000.0	-1000.0	-0.055	-1000.0
PDGFR-beta signaling pathway	3.0	356.0	97.0	-0.055	0.035	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by PRL	3.0	114.0	34.0	-0.102	0.032	1000.0	-1000.0	-0.04	-1000.0
FOXM1 transcription factor network	3.0	189.0	51.0	-0.1	0.137	1000.0	-1000.0	-0.198	-1000.0
Signaling events mediated by HDAC Class II	2.0	168.0	75.0	-0.077	0.034	1000.0	-1000.0	-0.043	-1000.0
Aurora A signaling	2.0	170.0	60.0	-0.125	0.038	1000.0	-1000.0	-0.049	-1000.0
mTOR signaling pathway	2.0	154.0	53.0	-0.016	0.023	1000.0	-1000.0	-0.064	-1000.0
ceramide signaling pathway	2.0	100.0	49.0	-0.041	0.03	1000.0	-1000.0	-0.054	-1000.0
HIF-2-alpha transcription factor network	2.0	114.0	43.0	-0.08	0.081	1000.0	-1000.0	-0.1	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	207.0	83.0	-0.077	0.054	1000.0	-1000.0	-0.072	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	35.0	23.0	-0.029	0.039	1000.0	-1000.0	-0.055	-1000.0
Canonical NF-kappaB pathway	1.0	76.0	39.0	-0.041	0.065	1000.0	-1000.0	-0.082	-1000.0
Circadian rhythm pathway	1.0	33.0	22.0	-0.022	0.04	1000.0	-1000.0	-0.05	-1000.0
Arf6 downstream pathway	1.0	70.0	43.0	-0.031	0.025	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.002	0.017	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	1.0	40.0	32.0	-0.046	0.038	1000.0	-1000.0	-0.069	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	81.0	68.0	-0.046	0.042	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class I	1.0	152.0	104.0	-0.041	0.046	1000.0	-1000.0	-0.066	-1000.0
FoxO family signaling	1.0	98.0	64.0	-0.074	0.125	1000.0	-1000.0	-0.072	-1000.0
Atypical NF-kappaB pathway	1.0	58.0	31.0	-0.013	0.04	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	105.0	76.0	-0.032	0.055	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling in keratinocytes	1.0	65.0	43.0	-0.039	0.036	1000.0	-1000.0	-0.07	-1000.0
Aurora B signaling	1.0	105.0	67.0	-0.067	0.034	1000.0	-1000.0	-0.072	-1000.0
PLK1 signaling events	0.0	66.0	85.0	-0.011	0.031	1000.0	-1000.0	-0.045	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.001	0.031	1000.0	-1000.0	-0.052	-1000.0
Arf6 trafficking events	0.0	69.0	71.0	-0.032	0.041	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	0.009	0.024	1000.0	-1000.0	-0.024	-1000.0
Arf1 pathway	0.0	35.0	54.0	-0.011	0.026	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.036	1000.0	-1000.0	-0.034	-1000.0
Total	1074	67751	7203	-16.2039412819	-994.629936953	131000	-131000	-8.94581085261	-131000