Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.042 -9999.0 0.0 -0.292 3.0 3.0 epithelial cell differentiation 0.048 0.032 -9999.0 0.0 -0.281 1.0 1.0 CYFIP2 0.012 0.073 -9999.0 0.0 -0.325 7.0 7.0 ENAH 0.019 0.085 0.279 3.0 -0.345 1.0 4.0 EGFR -0.017 0.148 -9999.0 0.0 -0.528 14.0 14.0 EPHA2 0.002 0.114 -9999.0 0.0 -0.528 8.0 8.0 MYO6 0.013 0.025 -9999.0 0.0 -0.271 1.0 1.0 CTNNB1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.054 -9999.0 0.0 -0.329 2.0 2.0 AQP5 -0.142 0.218 -9999.0 0.0 -0.469 54.0 54.0 CTNND1 0.024 0.041 -9999.0 0.0 -0.528 1.0 1.0 mol:PI-4-5-P2 0.012 0.024 0.177 1.0 -0.267 1.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.066 -9999.0 0.0 -0.265 7.0 7.0 EGF -0.035 0.144 -9999.0 0.0 -0.345 28.0 28.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.163 -9999.0 0.0 -0.459 24.0 24.0 cortical microtubule organization 0.048 0.032 -9999.0 0.0 -0.281 1.0 1.0 GO:0000145 -0.006 0.024 0.165 1.0 -0.255 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.034 -9999.0 0.0 -0.283 1.0 1.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.017 0.05 -9999.0 0.0 -0.466 1.0 1.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.033 0.072 -9999.0 0.0 -0.301 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.003 0.023 -9999.0 0.0 -0.246 1.0 1.0 PVRL2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.012 0.025 0.179 1.0 -0.271 1.0 2.0 ARF6/GTP 0.038 0.068 -9999.0 0.0 -0.282 5.0 5.0 CDH1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.011 0.118 -9999.0 0.0 -0.29 23.0 23.0 RhoA/GDP 0.049 0.032 -9999.0 0.0 -0.268 1.0 1.0 actin cytoskeleton organization -0.006 0.024 0.167 1.0 -0.265 1.0 2.0 IGF-1R heterotetramer 0.02 0.058 -9999.0 0.0 -0.527 2.0 2.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.058 -9999.0 0.0 -0.528 2.0 2.0 IGF1 -0.06 0.19 -9999.0 0.0 -0.436 34.0 34.0 DIAPH1 -0.012 0.161 -9999.0 0.0 -0.554 8.0 8.0 Wnt receptor signaling pathway -0.048 0.032 0.281 1.0 -9999.0 0.0 1.0 RHOA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.018 0.053 -9999.0 0.0 -0.466 1.0 1.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.006 0.024 -9999.0 0.0 -0.271 1.0 1.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.006 0.028 -9999.0 0.0 -0.264 2.0 2.0 Ephrin A1/EPHA2 0.026 0.075 -9999.0 0.0 -0.297 8.0 8.0 SEC6/SEC8 0.008 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.011 0.067 -9999.0 0.0 -0.269 7.0 7.0 HGF/MET 0.017 0.089 -9999.0 0.0 -0.285 12.0 12.0 HGF 0.002 0.1 -9999.0 0.0 -0.386 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.043 -9999.0 0.0 -0.294 3.0 3.0 actin cable formation 0.067 0.128 0.244 45.0 -0.269 1.0 46.0 KIAA1543 -0.011 0.045 0.167 1.0 -0.261 5.0 6.0 KIFC3 0.007 0.042 -9999.0 0.0 -0.273 4.0 4.0 NCK1 0.02 0.012 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.013 0.025 0.179 1.0 -0.271 1.0 2.0 NCK1/GIT1 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.032 -9999.0 0.0 -0.281 1.0 1.0 EXOC4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.012 0.021 -9999.0 0.0 -0.271 1.0 1.0 PIP5K1C 0.013 0.025 0.179 1.0 -0.271 1.0 2.0 LIMA1 0.021 0.058 -9999.0 0.0 -0.528 2.0 2.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.036 0.105 0.32 7.0 -0.408 1.0 8.0 adherens junction assembly -0.023 0.117 0.289 1.0 -0.471 9.0 10.0 IGF-1R heterotetramer/IGF1 -0.008 0.112 -9999.0 0.0 -0.275 23.0 23.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.004 0.107 -9999.0 0.0 -0.528 7.0 7.0 PLEKHA7 0.006 0.049 -9999.0 0.0 -0.273 5.0 5.0 mol:GTP 0.032 0.071 -9999.0 0.0 -0.299 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.033 0.085 0.325 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization 0.018 0.042 -9999.0 0.0 -0.292 3.0 3.0 regulation of cell-cell adhesion -0.006 0.024 0.167 1.0 -0.265 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.043 -9999.0 0.0 -0.294 3.0 3.0