Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.03 0.056 0.299 11.0 -0.245 1.0 12.0 KIRREL 0.023 0.044 -9999.0 0.0 -0.405 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.03 0.056 0.246 1.0 -0.299 11.0 12.0 PLCG1 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.044 0.075 -9999.0 0.0 -0.25 14.0 14.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.029 0.164 1.0 -9999.0 0.0 1.0 FYN 0.014 0.06 0.272 11.0 -0.234 5.0 16.0 mol:Ca2+ 0.029 0.052 -9999.0 0.0 -0.253 5.0 5.0 mol:DAG 0.029 0.053 -9999.0 0.0 -0.254 5.0 5.0 NPHS2 0.014 0.046 -9999.0 0.0 -0.418 4.0 4.0 mol:IP3 0.029 0.053 -9999.0 0.0 -0.254 5.0 5.0 regulation of endocytosis 0.037 0.047 0.217 1.0 -0.329 1.0 2.0 Nephrin/NEPH1/podocin/Cholesterol 0.037 0.051 0.219 1.0 -0.227 13.0 14.0 establishment of cell polarity 0.03 0.056 0.245 1.0 -0.299 11.0 12.0 Nephrin/NEPH1/podocin/NCK1-2 0.066 0.055 -9999.0 0.0 -0.376 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.039 0.048 0.225 1.0 -0.332 1.0 2.0 NPHS1 0.017 0.062 0.343 1.0 -0.425 7.0 8.0 Nephrin/NEPH1/podocin 0.039 0.047 0.221 1.0 -0.235 5.0 6.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.03 0.054 -9999.0 0.0 -0.255 5.0 5.0 CD2AP 0.014 0.073 -9999.0 0.0 -0.397 13.0 13.0 Nephrin/NEPH1/podocin/GRB2 0.052 0.056 0.237 1.0 -0.241 8.0 9.0 GRB2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.01 0.076 0.28 9.0 -0.242 19.0 28.0 cytoskeleton organization 0.011 0.041 0.202 5.0 -0.273 1.0 6.0 Nephrin/NEPH1 0.027 0.04 0.201 1.0 -0.204 11.0 12.0 Nephrin/NEPH1/ZO-1 0.042 0.049 0.232 1.0 -0.231 11.0 12.0