Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.097 -9999.0 0.0 -0.501 8.0 8.0 IHH 0.019 0.085 -9999.0 0.0 -0.452 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.043 0.124 0.189 1.0 -0.249 106.0 107.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.043 0.123 0.247 106.0 -0.187 1.0 107.0 SMO/beta Arrestin2 0.019 0.09 -9999.0 0.0 -0.46 6.0 6.0 SMO 0.006 0.084 -9999.0 0.0 -0.48 6.0 6.0 AKT1 0.001 0.105 -9999.0 0.0 -0.337 28.0 28.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.061 -9999.0 0.0 -0.397 9.0 9.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.008 0.085 -9999.0 0.0 -0.473 6.0 6.0 STIL -0.015 0.106 -9999.0 0.0 -0.387 6.0 6.0 DHH N/PTCH2 0.025 0.066 -9999.0 0.0 -0.28 19.0 19.0 DHH N/PTCH1 0.021 0.091 -9999.0 0.0 -0.409 8.0 8.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.086 -9999.0 0.0 -0.397 18.0 18.0 PTHLH 0.008 0.124 -9999.0 0.0 -0.74 8.0 8.0 determination of left/right symmetry 0.008 0.085 -9999.0 0.0 -0.473 6.0 6.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.008 0.123 -9999.0 0.0 -0.732 8.0 8.0 IHH N/Hhip -0.04 0.153 -9999.0 0.0 -0.318 95.0 95.0 DHH N/Hhip -0.04 0.147 -9999.0 0.0 -0.302 97.0 97.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.008 0.085 -9999.0 0.0 -0.473 6.0 6.0 pancreas development -0.063 0.171 -9999.0 0.0 -0.396 88.0 88.0 HHAT 0.023 0.041 -9999.0 0.0 -0.397 4.0 4.0 PI3K 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.028 0.143 -9999.0 0.0 -0.399 55.0 55.0 somite specification 0.008 0.085 -9999.0 0.0 -0.473 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.016 0.105 -9999.0 0.0 -0.373 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.017 0.098 0.189 4.0 -0.227 73.0 77.0 SHH Np/Cholesterol/Megalin -0.038 0.118 0.182 4.0 -0.244 99.0 103.0 SHH -0.037 0.12 0.278 4.0 -0.299 71.0 75.0 catabolic process 0.018 0.078 -9999.0 0.0 -0.401 8.0 8.0 SMO/Vitamin D3 -0.013 0.106 -9999.0 0.0 -0.408 8.0 8.0 SHH Np/Cholesterol/Hhip -0.061 0.126 0.187 3.0 -0.233 142.0 145.0 LRP2 -0.031 0.121 -9999.0 0.0 -0.421 36.0 36.0 receptor-mediated endocytosis -0.024 0.109 0.234 3.0 -0.422 10.0 13.0 SHH Np/Cholesterol/BOC -0.02 0.1 0.189 3.0 -0.229 77.0 80.0 SHH Np/Cholesterol/CDO -0.016 0.097 0.189 3.0 -0.227 72.0 75.0 mesenchymal cell differentiation 0.06 0.126 0.231 142.0 -0.185 3.0 145.0 mol:Vitamin D3 -0.009 0.113 -9999.0 0.0 -0.374 8.0 8.0 IHH N/PTCH2 0.031 0.057 -9999.0 0.0 -0.272 13.0 13.0 CDON 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.026 0.08 -9999.0 0.0 -0.404 8.0 8.0 Megalin/LRPAP1 0.007 0.094 -9999.0 0.0 -0.3 36.0 36.0 PTCH2 0.025 0.023 -9999.0 0.0 -0.421 1.0 1.0 SHH Np/Cholesterol -0.026 0.09 -9999.0 0.0 -0.225 72.0 72.0 PTCH1 0.018 0.078 -9999.0 0.0 -0.403 8.0 8.0 HHIP -0.063 0.171 -9999.0 0.0 -0.397 88.0 88.0