Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within IL4-mediated signaling events 9.0 870.0 91.0 -1.058 1.006 1000.0 -1000.0 -0.116 -1000.0 IL23-mediated signaling events 6.0 416.0 60.0 -0.533 0.018 1000.0 -1000.0 -0.132 -1000.0 TCGA08_p53 5.0 37.0 7.0 -0.106 0.066 1000.0 -1000.0 -0.008 -1000.0 TCGA08_retinoblastoma 5.0 41.0 8.0 -0.138 0.043 1000.0 -1000.0 -0.01 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 4.0 168.0 34.0 -0.211 0.014 1000.0 -1000.0 -0.023 -1000.0 Syndecan-1-mediated signaling events 4.0 165.0 34.0 -0.227 0.014 1000.0 -1000.0 -0.034 -1000.0 Glucocorticoid receptor regulatory network 4.0 495.0 114.0 -0.549 0.449 1000.0 -1000.0 -0.057 -1000.0 Signaling events regulated by Ret tyrosine kinase 4.0 371.0 82.0 -0.293 0.014 1000.0 -1000.0 -0.063 -1000.0 E-cadherin signaling events 4.0 21.0 5.0 -0.129 0.014 1000.0 -1000.0 -0.018 -1000.0 IL12-mediated signaling events 3.0 272.0 87.0 -0.276 0.133 1000.0 -1000.0 -0.106 -1000.0 Osteopontin-mediated events 3.0 151.0 38.0 -0.209 0.016 1000.0 -1000.0 -0.074 -1000.0 Noncanonical Wnt signaling pathway 3.0 84.0 26.0 -0.094 0.014 1000.0 -1000.0 -0.034 -1000.0 p75(NTR)-mediated signaling 3.0 437.0 125.0 -0.199 0.041 1000.0 -1000.0 -0.08 -1000.0 Endothelins 3.0 353.0 96.0 -0.214 0.014 1000.0 -1000.0 -0.052 -1000.0 Signaling mediated by p38-alpha and p38-beta 3.0 145.0 44.0 -0.147 0.014 1000.0 -1000.0 -0.03 -1000.0 TCR signaling in naïve CD8+ T cells 3.0 307.0 93.0 -0.152 0.02 1000.0 -1000.0 -0.061 -1000.0 Calcium signaling in the CD4+ TCR pathway 3.0 106.0 31.0 -0.359 0.014 1000.0 -1000.0 -0.046 -1000.0 Wnt signaling 3.0 21.0 7.0 -0.094 0.014 1000.0 -1000.0 -0.016 -1000.0 ErbB2/ErbB3 signaling events 2.0 135.0 65.0 -0.111 0.02 1000.0 -1000.0 -0.052 -1000.0 BARD1 signaling events 2.0 135.0 57.0 -0.185 0.124 1000.0 -1000.0 -0.048 -1000.0 Ephrin A reverse signaling 2.0 20.0 7.0 -0.104 0.003 1000.0 -1000.0 -0.016 -1000.0 Thromboxane A2 receptor signaling 2.0 241.0 105.0 -0.07 0.019 1000.0 -1000.0 -0.05 -1000.0 Arf6 signaling events 2.0 129.0 62.0 -0.139 0.035 1000.0 -1000.0 -0.034 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 2.0 196.0 85.0 -0.126 0.014 1000.0 -1000.0 -0.061 -1000.0 Arf6 downstream pathway 2.0 119.0 43.0 -0.169 0.073 1000.0 -1000.0 -0.027 -1000.0 amb2 Integrin signaling 2.0 231.0 82.0 -0.237 0.019 1000.0 -1000.0 -0.062 -1000.0 Nectin adhesion pathway 2.0 151.0 63.0 -0.139 0.027 1000.0 -1000.0 -0.06 -1000.0 Reelin signaling pathway 2.0 117.0 56.0 -0.115 0.027 1000.0 -1000.0 -0.062 -1000.0 Integrins in angiogenesis 2.0 227.0 84.0 -0.187 0.03 1000.0 -1000.0 -0.07 -1000.0 IL27-mediated signaling events 2.0 122.0 51.0 -0.203 0.094 1000.0 -1000.0 -0.075 -1000.0 LPA receptor mediated events 2.0 208.0 102.0 -0.16 0.014 1000.0 -1000.0 -0.07 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 2.0 165.0 68.0 -0.402 0.065 1000.0 -1000.0 -0.08 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 2.0 213.0 74.0 -0.148 0.07 1000.0 -1000.0 -0.072 -1000.0 Syndecan-4-mediated signaling events 2.0 139.0 67.0 -0.199 0.02 1000.0 -1000.0 -0.079 -1000.0 S1P3 pathway 2.0 85.0 42.0 -0.138 0.015 1000.0 -1000.0 -0.029 -1000.0 Angiopoietin receptor Tie2-mediated signaling 2.0 179.0 88.0 -0.282 0.021 1000.0 -1000.0 -0.085 -1000.0 Class IB PI3K non-lipid kinase events 2.0 6.0 3.0 -0.022 -1000.0 1000.0 -1000.0 -0.01 -1000.0 S1P4 pathway 2.0 59.0 25.0 -0.139 0.019 1000.0 -1000.0 -0.028 -1000.0 LPA4-mediated signaling events 1.0 19.0 12.0 -0.092 0.003 1000.0 -1000.0 -0.011 -1000.0 Caspase cascade in apoptosis 1.0 104.0 74.0 -0.123 0.061 1000.0 -1000.0 -0.03 -1000.0 Coregulation of Androgen receptor activity 1.0 100.0 76.0 -0.24 0.05 1000.0 -1000.0 -0.024 -1000.0 ErbB4 signaling events 1.0 79.0 69.0 -0.093 0.029 1000.0 -1000.0 -0.07 -1000.0 Sphingosine 1-phosphate (S1P) pathway 1.0 53.0 28.0 -0.139 0.023 1000.0 -1000.0 -0.023 -1000.0 Visual signal transduction: Cones 1.0 53.0 38.0 -0.092 0.014 1000.0 -1000.0 -0.045 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 1.0 75.0 54.0 -0.115 0.027 1000.0 -1000.0 -0.073 -1000.0 Signaling events mediated by the Hedgehog family 1.0 100.0 52.0 -0.12 0.019 1000.0 -1000.0 -0.034 -1000.0 JNK signaling in the CD4+ TCR pathway 1.0 17.0 17.0 -0.046 0.024 1000.0 -1000.0 -0.028 -1000.0 HIF-1-alpha transcription factor network 1.0 93.0 76.0 -0.21 0.038 1000.0 -1000.0 -0.087 -1000.0 Syndecan-2-mediated signaling events 1.0 105.0 69.0 -0.187 0.043 1000.0 -1000.0 -0.024 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 7.0 5.0 -0.046 0.014 1000.0 -1000.0 -0.014 -1000.0 Cellular roles of Anthrax toxin 1.0 44.0 39.0 -0.086 0.016 1000.0 -1000.0 -0.019 -1000.0 Signaling events mediated by PTP1B 1.0 117.0 76.0 -0.139 0.039 1000.0 -1000.0 -0.065 -1000.0 Presenilin action in Notch and Wnt signaling 1.0 91.0 61.0 -0.221 0.048 1000.0 -1000.0 -0.059 -1000.0 BMP receptor signaling 1.0 161.0 81.0 -0.224 0.031 1000.0 -1000.0 -0.067 -1000.0 Glypican 1 network 1.0 79.0 48.0 -0.263 0.033 1000.0 -1000.0 -0.024 -1000.0 Fc-epsilon receptor I signaling in mast cells 1.0 129.0 97.0 -0.11 0.032 1000.0 -1000.0 -0.067 -1000.0 PDGFR-alpha signaling pathway 1.0 62.0 44.0 -0.133 0.023 1000.0 -1000.0 -0.045 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 47.0 37.0 -0.187 0.034 1000.0 -1000.0 -0.039 -1000.0 IL1-mediated signaling events 1.0 73.0 62.0 -0.083 0.057 1000.0 -1000.0 -0.07 -1000.0 S1P5 pathway 1.0 29.0 17.0 -0.139 0.062 1000.0 -1000.0 -0.03 -1000.0 Ephrin B reverse signaling 1.0 74.0 48.0 -0.139 0.02 1000.0 -1000.0 -0.05 -1000.0 S1P1 pathway 1.0 70.0 36.0 -0.14 0.014 1000.0 -1000.0 -0.044 -1000.0 FAS signaling pathway (CD95) 1.0 80.0 47.0 -0.126 0.049 1000.0 -1000.0 -0.025 -1000.0 Signaling mediated by p38-gamma and p38-delta 1.0 21.0 15.0 -0.069 0.017 1000.0 -1000.0 -0.019 -1000.0 Syndecan-3-mediated signaling events 1.0 47.0 35.0 -0.187 0.041 1000.0 -1000.0 -0.026 -1000.0 IL2 signaling events mediated by PI3K 1.0 78.0 58.0 -0.104 0.022 1000.0 -1000.0 -0.066 -1000.0 Canonical Wnt signaling pathway 1.0 99.0 51.0 -0.221 0.054 1000.0 -1000.0 -0.044 -1000.0 EPHB forward signaling 1.0 108.0 85.0 -0.282 0.035 1000.0 -1000.0 -0.064 -1000.0 Effects of Botulinum toxin 1.0 39.0 26.0 -0.083 0.019 1000.0 -1000.0 -0.052 -1000.0 Glypican 2 network 1.0 4.0 4.0 0.002 0.006 1000.0 -1000.0 -0.009 -1000.0 Nongenotropic Androgen signaling 1.0 68.0 52.0 -0.139 0.028 1000.0 -1000.0 -0.04 -1000.0 TCGA08_rtk_signaling 1.0 31.0 26.0 -0.126 0.031 1000.0 -1000.0 -0.013 -1000.0 IL6-mediated signaling events 1.0 97.0 75.0 -0.2 0.04 1000.0 -1000.0 -0.066 -1000.0 E-cadherin signaling in the nascent adherens junction 1.0 149.0 76.0 -0.129 0.027 1000.0 -1000.0 -0.066 -1000.0 IL2 signaling events mediated by STAT5 1.0 25.0 22.0 -0.108 0.014 1000.0 -1000.0 -0.036 -1000.0 BCR signaling pathway 1.0 170.0 99.0 -0.105 0.041 1000.0 -1000.0 -0.071 -1000.0 EGFR-dependent Endothelin signaling events 1.0 28.0 21.0 -0.067 0.02 1000.0 -1000.0 -0.052 -1000.0 IGF1 pathway 1.0 76.0 57.0 -0.053 0.028 1000.0 -1000.0 -0.072 -1000.0 Insulin Pathway 1.0 82.0 74.0 -0.099 0.027 1000.0 -1000.0 -0.068 -1000.0 Plasma membrane estrogen receptor signaling 1.0 128.0 86.0 -0.139 0.046 1000.0 -1000.0 -0.071 -1000.0 VEGFR1 specific signals 1.0 70.0 56.0 -0.046 0.037 1000.0 -1000.0 -0.038 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 1.0 234.0 120.0 -0.201 0.149 1000.0 -1000.0 -0.055 -1000.0 Visual signal transduction: Rods 1.0 91.0 52.0 -0.168 0.014 1000.0 -1000.0 -0.064 -1000.0 E-cadherin signaling in keratinocytes 1.0 55.0 43.0 -0.129 0.017 1000.0 -1000.0 -0.047 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 1.0 113.0 78.0 -0.05 0.03 1000.0 -1000.0 -0.055 -1000.0 Regulation of Androgen receptor activity 1.0 101.0 70.0 -0.229 0.03 1000.0 -1000.0 -0.053 -1000.0 Ras signaling in the CD4+ TCR pathway 1.0 20.0 17.0 -0.016 0.025 1000.0 -1000.0 -0.022 -1000.0 Regulation of nuclear SMAD2/3 signaling 0.0 93.0 136.0 -0.203 0.082 1000.0 -1000.0 -0.058 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 6.0 23.0 -0.054 0.047 1000.0 -1000.0 -0.035 -1000.0 Canonical NF-kappaB pathway 0.0 4.0 39.0 -0.01 0.071 1000.0 -1000.0 -0.067 -1000.0 Signaling events mediated by HDAC Class II 0.0 35.0 75.0 -0.131 0.034 1000.0 -1000.0 -0.041 -1000.0 PLK2 and PLK4 events 0.0 2.0 3.0 -0.01 0.014 1000.0 -1000.0 -0.014 -1000.0 Circadian rhythm pathway 0.0 5.0 22.0 -0.029 0.045 1000.0 -1000.0 -0.029 -1000.0 Hedgehog signaling events mediated by Gli proteins 0.0 62.0 65.0 -0.139 0.051 1000.0 -1000.0 -0.049 -1000.0 Aurora A signaling 0.0 12.0 60.0 -0.034 0.04 1000.0 -1000.0 -0.03 -1000.0 Aurora C signaling 0.0 0.0 7.0 -0.0 0.027 1000.0 -1000.0 -0.021 -1000.0 FOXA2 and FOXA3 transcription factor networks 0.0 40.0 46.0 -0.083 0.042 1000.0 -1000.0 -0.075 -1000.0 EPO signaling pathway 0.0 14.0 55.0 -0.059 0.046 1000.0 -1000.0 -0.076 -1000.0 PLK1 signaling events 0.0 36.0 85.0 -0.048 0.036 1000.0 -1000.0 -0.033 -1000.0 Insulin-mediated glucose transport 0.0 17.0 32.0 -0.129 0.031 1000.0 -1000.0 -0.039 -1000.0 mTOR signaling pathway 0.0 26.0 53.0 -0.035 0.02 1000.0 -1000.0 -0.052 -1000.0 IFN-gamma pathway 0.0 39.0 68.0 -0.137 0.06 1000.0 -1000.0 -0.073 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 21.0 68.0 -0.129 0.043 1000.0 -1000.0 -0.031 -1000.0 Ceramide signaling pathway 0.0 30.0 76.0 -0.055 0.054 1000.0 -1000.0 -0.035 -1000.0 Signaling events mediated by HDAC Class III 0.0 27.0 40.0 -0.083 0.025 1000.0 -1000.0 -0.021 -1000.0 TRAIL signaling pathway 0.0 5.0 48.0 -0.011 0.046 1000.0 -1000.0 -0.057 -1000.0 ceramide signaling pathway 0.0 10.0 49.0 -0.055 0.057 1000.0 -1000.0 -0.04 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 0.0 25.0 52.0 -0.091 0.051 1000.0 -1000.0 -0.035 -1000.0 HIF-2-alpha transcription factor network 0.0 9.0 43.0 -0.154 0.157 1000.0 -1000.0 -0.062 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0 77.0 83.0 -0.131 0.036 1000.0 -1000.0 -0.054 -1000.0 Signaling events mediated by HDAC Class I 0.0 9.0 104.0 -0.035 0.055 1000.0 -1000.0 -0.055 -1000.0 FoxO family signaling 0.0 26.0 64.0 -0.129 0.072 1000.0 -1000.0 -0.05 -1000.0 Retinoic acid receptors-mediated signaling 0.0 29.0 58.0 -0.065 0.03 1000.0 -1000.0 -0.057 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 26.0 36.0 -0.046 0.028 1000.0 -1000.0 -0.057 -1000.0 Atypical NF-kappaB pathway 0.0 9.0 31.0 -0.031 0.043 1000.0 -1000.0 -0.022 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0 30.0 45.0 -0.035 0.059 1000.0 -1000.0 -0.068 -1000.0 Regulation of p38-alpha and p38-beta 0.0 52.0 54.0 -0.139 0.035 1000.0 -1000.0 -0.047 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 84.0 125.0 -0.139 0.052 1000.0 -1000.0 -0.067 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 0.0 27.0 -0.0 0.035 1000.0 -1000.0 -0.046 -1000.0 Class I PI3K signaling events 0.0 49.0 73.0 -0.07 0.034 1000.0 -1000.0 -0.049 -1000.0 Arf6 trafficking events 0.0 24.0 71.0 -0.07 0.043 1000.0 -1000.0 -0.061 -1000.0 Regulation of Telomerase 0.0 48.0 102.0 -0.085 0.048 1000.0 -1000.0 -0.077 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0 28.0 33.0 -0.142 0.043 1000.0 -1000.0 -0.038 -1000.0 Rapid glucocorticoid signaling 0.0 14.0 20.0 -0.035 0.014 1000.0 -1000.0 -0.017 -1000.0 PDGFR-beta signaling pathway 0.0 64.0 97.0 -0.282 0.056 1000.0 -1000.0 -0.063 -1000.0 Signaling events mediated by PRL 0.0 21.0 34.0 -0.119 0.044 1000.0 -1000.0 -0.031 -1000.0 FOXM1 transcription factor network 0.0 50.0 51.0 -0.147 0.152 1000.0 -1000.0 -0.143 -1000.0 p38 MAPK signaling pathway 0.0 32.0 44.0 -0.137 0.027 1000.0 -1000.0 -0.055 -1000.0 Arf1 pathway 0.0 0.0 54.0 -0.003 0.035 1000.0 -1000.0 -0.022 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 -0.0 0.041 1000.0 -1000.0 -0.026 -1000.0 Aurora B signaling 0.0 24.0 67.0 -0.099 0.033 1000.0 -1000.0 -0.046 -1000.0 Total 161 12346 7203 -18.3168734844 -993.684751177 131000 -131000 -6.38922987453 -131000