Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.311 0.329 -9999.0 0.0 -0.747 23.0 23.0 IHH -0.225 0.267 -9999.0 0.0 -0.573 25.0 25.0 SHH Np/Cholesterol/GAS1 -0.231 0.207 -9999.0 0.0 -0.441 28.0 28.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.229 0.205 0.437 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.274 0.291 -9999.0 0.0 -0.729 16.0 16.0 SMO -0.296 0.308 -9999.0 0.0 -0.703 21.0 21.0 AKT1 -0.109 0.115 -9999.0 0.0 -0.306 9.0 9.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.106 -9999.0 0.0 -0.513 3.0 3.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.29 0.3 -9999.0 0.0 -0.687 21.0 21.0 STIL -0.31 0.241 -9999.0 0.0 -0.52 32.0 32.0 DHH N/PTCH2 -0.048 0.161 -9999.0 0.0 -0.557 6.0 6.0 DHH N/PTCH1 -0.233 0.216 -9999.0 0.0 -0.525 21.0 21.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.042 0.187 -9999.0 0.0 -0.717 5.0 5.0 PTHLH -0.481 0.527 -9999.0 0.0 -1.197 23.0 23.0 determination of left/right symmetry -0.29 0.3 -9999.0 0.0 -0.687 21.0 21.0 PIK3R1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.472 0.515 -9999.0 0.0 -1.173 23.0 23.0 IHH N/Hhip -0.209 0.264 -9999.0 0.0 -0.534 24.0 24.0 DHH N/Hhip -0.122 0.227 -9999.0 0.0 -0.503 17.0 17.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.29 0.3 -9999.0 0.0 -0.687 21.0 21.0 pancreas development -0.107 0.25 -9999.0 0.0 -0.622 13.0 13.0 HHAT -0.021 0.147 -9999.0 0.0 -0.717 3.0 3.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.086 0.228 -9999.0 0.0 -0.606 11.0 11.0 somite specification -0.29 0.3 -9999.0 0.0 -0.687 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.333 0.254 -9999.0 0.0 -0.553 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.185 0.203 -9999.0 0.0 -0.393 33.0 33.0 SHH Np/Cholesterol/Megalin -0.23 0.254 -9999.0 0.0 -0.506 27.0 27.0 SHH -0.219 0.258 -9999.0 0.0 -0.486 33.0 33.0 catabolic process -0.223 0.238 -9999.0 0.0 -0.574 19.0 19.0 SMO/Vitamin D3 -0.36 0.288 -9999.0 0.0 -0.621 32.0 32.0 SHH Np/Cholesterol/Hhip -0.242 0.23 -9999.0 0.0 -0.472 29.0 29.0 LRP2 -0.085 0.236 -9999.0 0.0 -0.656 10.0 10.0 receptor-mediated endocytosis -0.378 0.293 -9999.0 0.0 -0.663 30.0 30.0 SHH Np/Cholesterol/BOC -0.189 0.204 -9999.0 0.0 -0.438 24.0 24.0 SHH Np/Cholesterol/CDO -0.181 0.193 -9999.0 0.0 -0.422 23.0 23.0 mesenchymal cell differentiation 0.24 0.228 0.469 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.333 0.255 -9999.0 0.0 -0.555 32.0 32.0 IHH N/PTCH2 -0.134 0.172 -9999.0 0.0 -0.385 18.0 18.0 CDON 0.003 0.062 -9999.0 0.0 -0.513 1.0 1.0 IHH N/PTCH1 -0.225 0.241 -9999.0 0.0 -0.58 19.0 19.0 Megalin/LRPAP1 -0.069 0.173 -9999.0 0.0 -0.486 10.0 10.0 PTCH2 -0.004 0.087 -9999.0 0.0 -0.513 2.0 2.0 SHH Np/Cholesterol -0.181 0.197 -9999.0 0.0 -0.384 33.0 33.0 PTCH1 -0.223 0.239 -9999.0 0.0 -0.576 19.0 19.0 HHIP -0.107 0.25 -9999.0 0.0 -0.623 13.0 13.0