Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.116 0.289 -9999.0 0.0 -0.559 20.0 20.0 IHH 0.015 0.107 0.204 9.0 -0.175 2.0 11.0 SHH Np/Cholesterol/GAS1 -0.065 0.15 -9999.0 0.0 -0.289 20.0 20.0 LRPAP1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.065 0.149 0.288 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.119 0.238 0.295 1.0 -0.513 13.0 14.0 SMO -0.137 0.238 0.312 1.0 -0.452 20.0 21.0 AKT1 -0.066 0.172 -9999.0 0.0 -0.613 4.0 4.0 ARRB2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.033 0.184 3.0 -9999.0 0.0 3.0 ADRBK1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.134 0.235 0.311 1.0 -0.445 20.0 21.0 STIL -0.115 0.156 0.219 1.0 -0.273 22.0 23.0 DHH N/PTCH2 0.011 0.103 -9999.0 0.0 -0.357 5.0 5.0 DHH N/PTCH1 -0.072 0.181 -9999.0 0.0 -0.293 27.0 27.0 PIK3CA 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.013 0.133 -9999.0 0.0 -0.49 5.0 5.0 PTHLH -0.232 0.465 -9999.0 0.0 -0.902 22.0 22.0 determination of left/right symmetry -0.134 0.235 0.311 1.0 -0.445 20.0 21.0 PIK3R1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.229 0.459 -9999.0 0.0 -0.89 22.0 22.0 IHH N/Hhip 0.019 0.156 0.268 1.0 -0.408 7.0 8.0 DHH N/Hhip -0.02 0.164 -9999.0 0.0 -0.384 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.134 0.235 0.311 1.0 -0.445 20.0 21.0 pancreas development -0.014 0.165 -9999.0 0.0 -0.489 7.0 7.0 HHAT 0.008 0.086 -9999.0 0.0 -0.49 2.0 2.0 PI3K 0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.143 0.184 6.0 -0.49 5.0 11.0 somite specification -0.134 0.235 0.311 1.0 -0.445 20.0 21.0 SHH Np/Cholesterol/PTCH1 -0.116 0.161 -9999.0 0.0 -0.271 29.0 29.0 SHH Np/Cholesterol/PTCH2 -0.051 0.131 0.162 2.0 -0.28 16.0 18.0 SHH Np/Cholesterol/Megalin -0.074 0.171 0.162 2.0 -0.335 19.0 21.0 SHH -0.08 0.154 -9999.0 0.0 -0.359 16.0 16.0 catabolic process -0.063 0.189 -9999.0 0.0 -0.333 22.0 22.0 SMO/Vitamin D3 -0.143 0.207 0.378 1.0 -0.382 20.0 21.0 SHH Np/Cholesterol/Hhip -0.073 0.164 0.162 2.0 -0.306 21.0 23.0 LRP2 -0.02 0.16 0.184 3.0 -0.49 7.0 10.0 receptor-mediated endocytosis -0.172 0.211 -9999.0 0.0 -0.458 17.0 17.0 SHH Np/Cholesterol/BOC -0.051 0.13 0.162 1.0 -0.28 16.0 17.0 SHH Np/Cholesterol/CDO -0.052 0.126 -9999.0 0.0 -0.277 16.0 16.0 mesenchymal cell differentiation 0.072 0.163 0.304 21.0 -0.16 2.0 23.0 mol:Vitamin D3 -0.105 0.176 0.321 1.0 -0.273 28.0 29.0 IHH N/PTCH2 0.057 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.042 0.206 -9999.0 0.0 -0.335 22.0 22.0 Megalin/LRPAP1 0.002 0.119 -9999.0 0.0 -0.347 7.0 7.0 PTCH2 0.03 0.026 0.184 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol -0.06 0.119 -9999.0 0.0 -0.275 16.0 16.0 PTCH1 -0.064 0.189 -9999.0 0.0 -0.334 22.0 22.0 HHIP -0.014 0.165 -9999.0 0.0 -0.49 7.0 7.0