Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	13.0	678.0	52.0	-0.232	0.072	1000.0	-1000.0	-0.028	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	608.0	46.0	-0.385	0.036	1000.0	-1000.0	-0.076	-1000.0
S1P5 pathway	9.0	159.0	17.0	-0.145	0.09	1000.0	-1000.0	-0.01	-1000.0
Ephrin B reverse signaling	9.0	441.0	48.0	-0.165	0.024	1000.0	-1000.0	-0.025	-1000.0
IL23-mediated signaling events	9.0	597.0	60.0	-0.32	0.027	1000.0	-1000.0	-0.08	-1000.0
Ephrin A  reverse signaling	8.0	57.0	7.0	-0.056	0.003	1000.0	-1000.0	-0.016	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	386.0	44.0	-0.096	0.025	1000.0	-1000.0	-0.036	-1000.0
TCGA08_retinoblastoma	8.0	70.0	8.0	-0.053	0.079	1000.0	-1000.0	-0.003	-1000.0
Osteopontin-mediated events	7.0	266.0	38.0	-0.116	0.035	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	7.0	394.0	55.0	-0.014	0.032	1000.0	-1000.0	-0.032	-1000.0
TCR signaling in naïve CD8+ T cells	7.0	670.0	93.0	-0.119	0.036	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.027	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	212.0	34.0	-0.026	0.029	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	6.0	225.0	34.0	-0.073	0.025	1000.0	-1000.0	-0.041	-1000.0
p75(NTR)-mediated signaling	6.0	839.0	125.0	-0.101	0.067	1000.0	-1000.0	-0.067	-1000.0
Glypican 1 network	6.0	331.0	48.0	-0.093	0.026	1000.0	-1000.0	-0.03	-1000.0
Glucocorticoid receptor regulatory network	6.0	730.0	114.0	-0.461	0.166	1000.0	-1000.0	-0.047	-1000.0
Endothelins	6.0	641.0	96.0	-0.104	0.037	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	6.0	42.0	7.0	-0.024	0.02	1000.0	-1000.0	-0.009	-1000.0
LPA receptor mediated events	6.0	660.0	102.0	-0.149	0.041	1000.0	-1000.0	-0.061	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	421.0	68.0	-0.211	0.069	1000.0	-1000.0	-0.076	-1000.0
Syndecan-4-mediated signaling events	6.0	444.0	67.0	-0.1	0.027	1000.0	-1000.0	-0.036	-1000.0
IL4-mediated signaling events	5.0	522.0	91.0	-0.371	0.2	1000.0	-1000.0	-0.126	-1000.0
BMP receptor signaling	5.0	414.0	81.0	-0.09	0.044	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	5.0	473.0	85.0	-0.073	0.106	1000.0	-1000.0	-0.06	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	167.0	31.0	-0.136	0.025	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Rods	5.0	283.0	52.0	-0.096	0.039	1000.0	-1000.0	-0.033	-1000.0
S1P4 pathway	5.0	128.0	25.0	-0.145	0.045	1000.0	-1000.0	-0.023	-1000.0
IL12-mediated signaling events	4.0	399.0	87.0	-0.135	0.042	1000.0	-1000.0	-0.06	-1000.0
Noncanonical Wnt signaling pathway	4.0	120.0	26.0	-0.035	0.025	1000.0	-1000.0	-0.037	-1000.0
Thromboxane A2 receptor signaling	4.0	430.0	105.0	-0.04	0.038	1000.0	-1000.0	-0.038	-1000.0
HIF-1-alpha transcription factor network	4.0	346.0	76.0	-0.066	0.052	1000.0	-1000.0	-0.052	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	390.0	97.0	-0.043	0.052	1000.0	-1000.0	-0.062	-1000.0
amb2 Integrin signaling	4.0	356.0	82.0	-0.079	0.038	1000.0	-1000.0	-0.031	-1000.0
Canonical Wnt signaling pathway	4.0	231.0	51.0	-0.033	0.18	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	4.0	16.0	4.0	-0.001	0.012	1000.0	-1000.0	0.013	-1000.0
BCR signaling pathway	4.0	455.0	99.0	-0.097	0.035	1000.0	-1000.0	-0.049	-1000.0
EGFR-dependent Endothelin signaling events	4.0	96.0	21.0	-0.042	0.036	1000.0	-1000.0	-0.041	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	530.0	120.0	-0.101	0.067	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	100.0	28.0	-0.145	0.034	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	3.0	147.0	38.0	-0.067	0.044	1000.0	-1000.0	-0.023	-1000.0
Arf6 signaling events	3.0	194.0	62.0	-0.027	0.049	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	3.0	229.0	76.0	-0.031	0.066	1000.0	-1000.0	-0.024	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	277.0	82.0	-0.033	0.031	1000.0	-1000.0	-0.057	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	160.0	52.0	-0.06	0.047	1000.0	-1000.0	-0.038	-1000.0
S1P1 pathway	3.0	138.0	36.0	-0.136	0.024	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	3.0	145.0	47.0	-0.059	0.035	1000.0	-1000.0	-0.03	-1000.0
Effects of Botulinum toxin	3.0	82.0	26.0	-0.049	0.024	1000.0	-1000.0	-0.014	-1000.0
IL27-mediated signaling events	3.0	177.0	51.0	-0.126	0.059	1000.0	-1000.0	-0.055	-1000.0
IGF1 pathway	3.0	174.0	57.0	-0.037	0.051	1000.0	-1000.0	-0.05	-1000.0
S1P3 pathway	3.0	143.0	42.0	-0.044	0.036	1000.0	-1000.0	-0.034	-1000.0
ErbB2/ErbB3 signaling events	2.0	158.0	65.0	-0.031	0.036	1000.0	-1000.0	-0.051	-1000.0
Caspase cascade in apoptosis	2.0	216.0	74.0	-0.101	0.039	1000.0	-1000.0	-0.033	-1000.0
ErbB4 signaling events	2.0	175.0	69.0	-0.106	0.048	1000.0	-1000.0	-0.041	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.029	0.051	1000.0	-1000.0	-0.029	-1000.0
Syndecan-2-mediated signaling events	2.0	206.0	69.0	-0.03	0.038	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	2.0	212.0	76.0	-0.053	0.04	1000.0	-1000.0	-0.044	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	185.0	65.0	-0.277	0.061	1000.0	-1000.0	-0.043	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	169.0	61.0	-0.034	0.08	1000.0	-1000.0	-0.045	-1000.0
IFN-gamma pathway	2.0	140.0	68.0	-0.045	0.038	1000.0	-1000.0	-0.058	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	83.0	37.0	-0.02	0.054	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	2.0	160.0	56.0	-0.035	0.064	1000.0	-1000.0	-0.041	-1000.0
IL1-mediated signaling events	2.0	175.0	62.0	-0.038	0.047	1000.0	-1000.0	-0.049	-1000.0
ceramide signaling pathway	2.0	113.0	49.0	-0.028	0.042	1000.0	-1000.0	-0.022	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	34.0	15.0	-0.027	0.024	1000.0	-1000.0	-0.029	-1000.0
Retinoic acid receptors-mediated signaling	2.0	138.0	58.0	-0.038	0.047	1000.0	-1000.0	-0.042	-1000.0
IL2 signaling events mediated by PI3K	2.0	133.0	58.0	-0.105	0.056	1000.0	-1000.0	-0.03	-1000.0
Integrins in angiogenesis	2.0	230.0	84.0	-0.073	0.054	1000.0	-1000.0	-0.05	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	118.0	45.0	-0.064	0.044	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	158.0	74.0	-0.124	0.051	1000.0	-1000.0	-0.066	-1000.0
PDGFR-beta signaling pathway	2.0	244.0	97.0	-0.076	0.049	1000.0	-1000.0	-0.052	-1000.0
Regulation of Androgen receptor activity	2.0	192.0	70.0	-0.26	0.033	1000.0	-1000.0	-0.05	-1000.0
LPA4-mediated signaling events	1.0	19.0	12.0	-0.026	0.025	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	255.0	136.0	-0.291	0.074	1000.0	-1000.0	-0.041	-1000.0
Coregulation of Androgen receptor activity	1.0	132.0	76.0	-0.196	0.044	1000.0	-1000.0	-0.022	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	100.0	54.0	-0.035	0.036	1000.0	-1000.0	-0.054	-1000.0
Cellular roles of Anthrax toxin	1.0	68.0	39.0	-0.033	0.029	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	128.0	85.0	-0.016	0.041	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	1.0	74.0	43.0	-0.036	0.033	1000.0	-1000.0	-0.039	-1000.0
Nectin adhesion pathway	1.0	122.0	63.0	-0.025	0.046	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	1.0	48.0	40.0	-0.056	0.047	1000.0	-1000.0	-0.024	-1000.0
HIF-2-alpha transcription factor network	1.0	78.0	43.0	-0.039	0.043	1000.0	-1000.0	-0.047	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	92.0	83.0	-0.032	0.048	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	1.0	11.0	7.0	-0.012	0.024	1000.0	-1000.0	-0.012	-1000.0
Syndecan-3-mediated signaling events	1.0	60.0	35.0	-0.023	0.067	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	1.0	103.0	54.0	-0.044	0.052	1000.0	-1000.0	-0.045	-1000.0
Nongenotropic Androgen signaling	1.0	77.0	52.0	-0.029	0.041	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	1.0	38.0	26.0	-0.057	0.084	1000.0	-1000.0	-0.012	-1000.0
IL6-mediated signaling events	1.0	103.0	75.0	-0.018	0.064	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	118.0	76.0	-0.034	0.054	1000.0	-1000.0	-0.056	-1000.0
IL2 signaling events mediated by STAT5	1.0	39.0	22.0	-0.007	0.044	1000.0	-1000.0	-0.037	-1000.0
Class I PI3K signaling events	1.0	133.0	73.0	-0.041	0.043	1000.0	-1000.0	-0.032	-1000.0
Regulation of Telomerase	1.0	122.0	102.0	-0.022	0.057	1000.0	-1000.0	-0.046	-1000.0
Plasma membrane estrogen receptor signaling	1.0	169.0	86.0	-0.068	0.054	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	173.0	88.0	-0.035	0.029	1000.0	-1000.0	-0.059	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	57.0	33.0	-0.011	0.057	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PRL	1.0	34.0	34.0	-0.02	0.041	1000.0	-1000.0	-0.036	-1000.0
E-cadherin signaling in keratinocytes	1.0	63.0	43.0	-0.023	0.04	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	110.0	78.0	-0.034	0.033	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	24.0	17.0	-0.003	0.037	1000.0	-1000.0	-0.025	-1000.0
Aurora B signaling	1.0	73.0	67.0	-0.102	0.073	1000.0	-1000.0	-0.034	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	3.0	23.0	0.003	0.042	1000.0	-1000.0	-0.027	-1000.0
Canonical NF-kappaB pathway	0.0	27.0	39.0	-0.004	0.046	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class II	0.0	28.0	75.0	-0.025	0.066	1000.0	-1000.0	-0.027	-1000.0
BARD1 signaling events	0.0	21.0	57.0	-0.046	0.065	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	-0.014	0.025	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.013	0.039	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.018	0.034	1000.0	-1000.0	0.012	-1000.0
Aurora A signaling	0.0	37.0	60.0	-0.02	0.055	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	5.0	7.0	0.0	0.044	1000.0	-1000.0	-0.014	-1000.0
PLK1 signaling events	0.0	74.0	85.0	-0.016	0.043	1000.0	-1000.0	-0.028	-1000.0
Insulin-mediated glucose transport	0.0	12.0	32.0	-0.032	0.047	1000.0	-1000.0	-0.031	-1000.0
PDGFR-alpha signaling pathway	0.0	8.0	44.0	-0.034	0.057	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	0.0	34.0	53.0	-0.021	0.057	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	63.0	68.0	-0.033	0.051	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	0.0	31.0	48.0	-0.008	0.082	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	0.0	96.0	104.0	-0.046	0.062	1000.0	-1000.0	-0.03	-1000.0
FoxO family signaling	0.0	58.0	64.0	-0.112	0.067	1000.0	-1000.0	-0.046	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	28.0	36.0	-0.038	0.045	1000.0	-1000.0	-0.039	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.013	0.025	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	122.0	125.0	-0.025	0.052	1000.0	-1000.0	-0.051	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.017	0.055	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	0.0	25.0	71.0	-0.034	0.044	1000.0	-1000.0	-0.035	-1000.0
Insulin Pathway	0.0	51.0	74.0	-0.026	0.056	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	0.0	27.0	56.0	-0.022	0.047	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.009	0.032	1000.0	-1000.0	-0.016	-1000.0
FOXM1 transcription factor network	0.0	35.0	51.0	-0.006	0.152	1000.0	-1000.0	-0.09	-1000.0
E-cadherin signaling events	0.0	4.0	5.0	0.016	0.035	1000.0	-1000.0	0.01	-1000.0
p38 MAPK signaling pathway	0.0	31.0	44.0	-0.018	0.055	1000.0	-1000.0	-0.02	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.007	0.032	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.063	1000.0	-1000.0	-0.0	-1000.0
Total	346	22997	7203	-9.03056594636	-993.55778054	131000	-131000	-4.81823622687	-131000