Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q amp_2q11.2 104 (20%) 407 6.8222e-12 4.62e-09 3.5471e-14 2.43e-11 0.49915 1 0.30966 1 0.050541 1 0.12464 1 0.064802 1 0.36131 1 0.14771 1 0.52098 1 amp_2q31.2 108 (21%) 403 5.0121e-15 3.47e-12 1.3241e-16 9.27e-14 0.2406 1 0.61531 1 0.18925 1 0.14526 1 0.19123 1 0.73591 1 0.33115 1 0.87246 1 amp_3q26.33 372 (73%) 139 1.0037e-18 7.09e-16 3.5192e-15 2.44e-12 0.12913 1 0.31697 1 2.2565e-07 0.000146 2.707e-05 0.0164 0.00016652 0.0986 0.41275 1 0.042467 1 0.16466 1 amp_5p15.33 231 (45%) 280 5.0094e-19 3.55e-16 2.3066e-06 0.00145 0.84692 1 0.4514 1 0.15501 1 0.17253 1 0.68666 1 1 1 0.96281 1 1 1 amp_5p12 203 (40%) 308 1.545e-15 1.08e-12 6.5065e-05 0.039 0.57448 1 0.06841 1 0.31094 1 0.43525 1 0.58108 1 0.70827 1 0.98896 1 0.95348 1 amp_6p12.1 107 (21%) 404 3.2283e-08 2.12e-05 1.3098e-05 0.00799 0.45033 1 0.78652 1 0.84719 1 0.62454 1 0.44848 1 0.042245 1 0.91701 1 0.35784 1 amp_6q12 92 (18%) 419 1.6332e-08 1.08e-05 0.0003278 0.189 0.27922 1 0.66663 1 0.85038 1 0.98306 1 0.30147 1 0.18831 1 0.79625 1 0.77466 1 amp_7p11.2 215 (42%) 296 1.0322e-12 7.04e-10 6.6557e-12 4.51e-09 0.994 1 0.18648 1 0.048628 1 0.060006 1 0.7163 1 0.16432 1 0.26276 1 0.37682 1 amp_7q21.3 164 (32%) 347 8.9136e-15 6.15e-12 1.6465e-15 1.15e-12 0.32932 1 1 1 0.30491 1 0.73498 1 0.084156 1 0.4309 1 0.28432 1 0.61889 1 amp_8p11.23 156 (31%) 355 2.5278e-06 0.00158 0.014242 1 0.80044 1 0.65375 1 0.12792 1 0.079898 1 0.0031904 1 0.021744 1 0.28695 1 0.12909 1 amp_8q11.21 305 (60%) 206 2.8541e-11 1.93e-08 1.3449e-07 8.74e-05 0.098277 1 0.42915 1 0.0015776 0.888 0.00020776 0.122 0.033645 1 0.00026699 0.155 0.048183 1 0.0015078 0.85 amp_8q24.21 379 (74%) 132 3.5914e-17 2.52e-14 2.1814e-10 1.46e-07 0.31014 1 0.46678 1 0.012742 1 7.2595e-05 0.0434 0.064552 1 0.0032991 1 0.001864 1 0.014988 1 amp_9p24.1 122 (24%) 389 3.7322e-21 2.68e-18 5.294e-06 0.00328 0.13613 1 0.12672 1 0.0028632 1 0.0020594 1 0.034856 1 0.59263 1 0.1599 1 0.48096 1 amp_9p23 121 (24%) 390 2.1665e-19 1.54e-16 1.3012e-05 0.00795 0.38513 1 0.40723 1 0.00335 1 0.0052965 1 0.059506 1 1 1 0.27121 1 0.62595 1 amp_9p13.3 135 (26%) 376 2.1913e-14 1.51e-11 0.0035093 1 0.47979 1 0.51719 1 0.00086011 0.493 0.0033147 1 0.0029691 1 0.037711 1 0.83421 1 0.2066 1 amp_9q34.3 174 (34%) 337 9.0513e-14 6.2e-11 0.0029803 1 0.23878 1 0.1484 1 0.94995 1 0.20853 1 0.70956 1 0.69927 1 0.91996 1 0.84691 1 amp_11p13 101 (20%) 410 0.00024258 0.142 0.0025986 1 0.45581 1 0.32128 1 0.95667 1 0.49803 1 0.80455 1 0.24562 1 0.31474 1 0.49532 1 amp_11q13.3 223 (44%) 288 1.8601e-26 1.35e-23 7.2606e-11 4.89e-08 0.82829 1 0.9272 1 0.17146 1 0.068681 1 0.41451 1 0.1394 1 0.24935 1 0.39352 1 amp_12p13.33 162 (32%) 349 2.8164e-17 1.98e-14 1.6848e-07 0.000109 0.042947 1 0.096592 1 0.0092718 1 0.010554 1 0.023356 1 0.76794 1 0.16854 1 0.82657 1 amp_12q15 101 (20%) 410 3.462e-07 0.000222 0.00038989 0.225 0.067753 1 0.60685 1 0.12642 1 0.093084 1 0.90727 1 0.90873 1 1 1 0.32698 1 amp_13q22.1 104 (20%) 407 1.9237e-13 1.31e-10 4.3598e-06 0.0027 0.14972 1 0.37382 1 0.32609 1 0.35612 1 0.43572 1 0.13696 1 0.82653 1 0.40805 1 amp_13q34 106 (21%) 405 1.3306e-09 8.84e-07 7.3945e-05 0.0441 0.25238 1 0.66114 1 0.19841 1 0.26769 1 0.34523 1 0.053041 1 0.334 1 0.16363 1 amp_15q26.3 102 (20%) 409 0.0019494 1 0.01535 1 0.45193 1 0.91557 1 0.61145 1 0.64665 1 0.33209 1 0.4893 1 0.68304 1 0.43919 1 amp_17q12 88 (17%) 423 1.9652e-08 1.29e-05 1.4554e-06 0.000915 0.18689 1 0.5439 1 0.010882 1 0.11493 1 0.010085 1 1 1 1 1 1 1 amp_18p11.31 152 (30%) 359 6.7675e-17 4.74e-14 2.1955e-09 1.46e-06 0.51924 1 0.81768 1 0.080561 1 4.2845e-05 0.0258 0.76272 1 0.27166 1 0.56727 1 0.23069 1 amp_18q11.2 101 (20%) 410 5.7754e-07 0.000367 0.00020776 0.122 0.51715 1 0.83009 1 0.36915 1 0.014094 1 0.038495 1 0.24888 1 0.81748 1 0.90421 1 amp_20p12.2 189 (37%) 322 2.7965e-05 0.0169 2.6657e-05 0.0162 0.87267 1 0.69874 1 0.088995 1 0.055905 1 0.14944 1 0.001265 0.715 0.022984 1 0.030948 1 amp_20q11.22 224 (44%) 287 4.7727e-08 3.12e-05 8.5397e-06 0.00525 0.49944 1 0.12579 1 0.10562 1 0.338 1 0.4755 1 0.012507 1 0.22936 1 0.024604 1 amp_xq28 145 (28%) 366 2.3239e-10 1.56e-07 3.9649e-06 0.00247 0.63529 1 0.26261 1 0.29789 1 0.2397 1 0.15557 1 0.065772 1 0.95451 1 0.69465 1 del_1p36.21 94 (18%) 417 3.0443e-10 2.03e-07 8.2629e-19 5.84e-16 0.00084556 0.486 0.60675 1 4.1946e-07 0.000268 5.5363e-05 0.0333 0.00086385 0.494 0.095303 1 0.04088 1 0.013476 1 del_1p13.2 127 (25%) 384 6.0511e-16 4.23e-13 5.5749e-15 3.86e-12 0.025627 1 0.37983 1 0.025781 1 0.041755 1 0.018017 1 0.91536 1 0.096666 1 0.012322 1 del_1q44 47 (9%) 464 0.00098551 0.563 0.0051785 1 0.71192 1 0.8285 1 0.013842 1 0.019465 1 0.00054949 0.317 0.037548 1 0.023738 1 0.40366 1 del_2q21.2 73 (14%) 438 0.81917 1 0.021595 1 0.70195 1 0.76963 1 0.025604 1 0.0017283 0.964 0.00025197 0.147 0.51139 1 0.066707 1 0.52431 1 del_2q22.1 114 (22%) 397 0.068414 1 1.9141e-05 0.0117 0.34958 1 0.8835 1 0.28281 1 0.13546 1 0.17565 1 0.44307 1 0.89357 1 0.44465 1 del_2q36.2 152 (30%) 359 4.3898e-08 2.87e-05 1.4639e-07 9.5e-05 0.091498 1 0.51364 1 0.010545 1 0.0032177 1 0.092178 1 0.4813 1 0.12932 1 0.078896 1 del_3p24.1 357 (70%) 154 2.1714e-31 1.58e-28 3.1847e-24 2.3e-21 0.41173 1 0.082634 1 0.0016304 0.916 0.010707 1 0.0079183 1 0.0050395 1 0.11141 1 0.058311 1 del_3p12.1 332 (65%) 179 1.627e-33 1.19e-30 1.3846e-24 1e-21 0.82719 1 0.34292 1 0.020849 1 0.060174 1 0.076238 1 0.068083 1 0.34091 1 0.67868 1 del_4p15.2 201 (39%) 310 1.3878e-17 9.77e-15 3.452e-15 2.4e-12 0.011563 1 0.78197 1 9.527e-05 0.0567 7.1155e-05 0.0426 0.053163 1 1 1 0.0038185 1 0.019056 1 del_4q22.1 164 (32%) 347 5.6737e-15 3.92e-12 1.9774e-10 1.33e-07 0.24817 1 0.40341 1 0.0087779 1 0.0069821 1 0.208 1 0.376 1 0.47365 1 0.14694 1 del_4q35.2 206 (40%) 305 1.0546e-11 7.13e-09 1.2729e-05 0.00779 0.83958 1 0.00024641 0.144 0.012151 1 0.044163 1 0.32534 1 0.050146 1 0.40744 1 0.10986 1 del_5q11.2 209 (41%) 302 9.4851e-31 6.91e-28 2.4654e-22 1.78e-19 0.13206 1 0.17659 1 0.10115 1 0.0012478 0.706 0.18444 1 0.22489 1 0.3843 1 0.48153 1 del_5q15 219 (43%) 292 3.0141e-29 2.19e-26 6.1352e-21 4.39e-18 0.14324 1 0.65365 1 0.10937 1 0.0024773 1 0.23384 1 0.26715 1 0.62495 1 0.8062 1 del_5q35.3 195 (38%) 316 8.8197e-25 6.39e-22 6.4712e-21 4.63e-18 0.23762 1 0.02752 1 0.01935 1 0.00027952 0.162 0.33522 1 0.18693 1 0.45698 1 0.32872 1 del_6p25.3 93 (18%) 418 0.00028907 0.167 9.8519e-06 0.00605 0.044011 1 0.57385 1 0.0022871 1 0.1353 1 0.19465 1 0.81309 1 0.67658 1 0.3238 1 del_7q31.1 74 (14%) 437 0.0064342 1 0.28349 1 0.57268 1 0.83498 1 0.52088 1 0.48277 1 0.87673 1 1 1 0.57779 1 0.46008 1 del_7q36.1 127 (25%) 384 0.00010371 0.0615 0.44497 1 0.044908 1 0.92634 1 0.76747 1 0.9248 1 0.62887 1 0.91536 1 0.74988 1 0.41651 1 del_8p23.2 294 (58%) 217 1.4375e-21 1.03e-18 1.2559e-12 8.55e-10 0.28165 1 0.12161 1 0.0011926 0.676 1.2641e-05 0.00775 0.0020242 1 0.0022051 1 0.00021778 0.128 6.197e-05 0.0372 del_9p23 233 (46%) 278 1.9898e-28 1.44e-25 1.4765e-19 1.05e-16 0.28096 1 0.08739 1 0.82309 1 0.87601 1 0.76181 1 1 1 0.25439 1 0.92832 1 del_9p21.3 292 (57%) 219 4.7906e-18 3.38e-15 9.1592e-20 6.51e-17 0.66249 1 0.088644 1 0.14447 1 0.18056 1 1 1 0.35417 1 0.10795 1 0.015212 1 del_9q21.11 103 (20%) 408 1.4025e-13 9.59e-11 2.2508e-07 0.000145 0.96951 1 0.54095 1 0.85172 1 0.92442 1 0.72515 1 0.30171 1 0.48387 1 0.12151 1 del_9q34.3 76 (15%) 435 5.3929e-07 0.000344 0.0010759 0.612 0.60565 1 0.2732 1 0.44555 1 0.58767 1 0.71556 1 0.89833 1 0.19588 1 0.39974 1 del_10p15.3 165 (32%) 346 7.6955e-07 0.000488 8.4258e-07 0.000533 0.60139 1 0.33923 1 0.12632 1 0.12792 1 0.14522 1 0.06185 1 0.099726 1 0.33737 1 del_10p11.21 152 (30%) 359 2.3397e-08 1.54e-05 2.2865e-07 0.000147 0.45344 1 0.064173 1 0.27652 1 0.57075 1 0.017591 1 0.48203 1 0.13242 1 0.7912 1 del_10q23.31 134 (26%) 377 6.9727e-06 0.0043 1.3692e-06 0.000863 0.1339 1 0.8654 1 7.4193e-05 0.0442 0.0016884 0.944 0.0074511 1 0.53148 1 0.043975 1 0.51115 1 del_11p15.5 156 (31%) 355 7.6422e-11 5.14e-08 2.5171e-10 1.68e-07 0.86069 1 0.54759 1 3.7618e-05 0.0227 0.00020721 0.122 2.0949e-07 0.000136 0.11159 1 0.16131 1 0.0095294 1 del_11q23.1 239 (47%) 272 2.1566e-06 0.00135 2.4465e-15 1.7e-12 0.087819 1 0.042172 1 3.0852e-05 0.0187 4.2202e-06 0.00262 0.0019633 1 0.19881 1 0.022829 1 0.10873 1 del_12q24.33 60 (12%) 451 3.6049e-06 0.00225 0.00016935 0.1 0.61174 1 0.71815 1 0.85129 1 0.68632 1 0.49159 1 0.56237 1 0.059461 1 0.34181 1 del_13q12.11 224 (44%) 287 8.601e-21 6.14e-18 4.0633e-12 2.76e-09 0.1476 1 0.67692 1 0.024576 1 0.0016602 0.93 0.82625 1 0.71169 1 0.59171 1 0.088158 1 del_13q14.2 209 (41%) 302 2.1636e-14 1.49e-11 1.2042e-09 8.02e-07 0.10927 1 0.8245 1 5.4386e-06 0.00336 1.1736e-08 7.75e-06 0.0035031 1 0.30497 1 0.19621 1 0.0097128 1 del_14q11.2 72 (14%) 439 0.0035522 1 0.019699 1 0.3138 1 0.71254 1 0.11365 1 0.32397 1 0.036833 1 0.022371 1 0.15794 1 0.078116 1 del_14q32.32 73 (14%) 438 0.0002556 0.149 2.8083e-12 1.91e-09 0.019079 1 0.14962 1 8.8947e-07 0.000561 1.0159e-07 6.61e-05 0.0032818 1 0.018252 1 0.019478 1 0.0026584 1 del_15q15.1 119 (23%) 392 7.5278e-09 4.98e-06 0.21931 1 0.668 1 0.24331 1 0.071014 1 0.013947 1 0.79968 1 0.51616 1 0.68963 1 0.53527 1 del_16q23.3 102 (20%) 409 0.0011773 0.669 4.6253e-07 0.000296 0.16003 1 0.068121 1 4.0043e-06 0.00249 2.3722e-07 0.000153 0.0040432 1 0.050558 1 0.0060045 1 0.016452 1 del_17q25.3 68 (13%) 443 0.039053 1 0.00023331 0.137 0.42568 1 0.092978 1 0.01238 1 0.0016536 0.928 0.003749 1 0.03024 1 0.0048932 1 0.060463 1 del_18q21.2 259 (51%) 252 2.4445e-20 1.74e-17 1.2995e-20 9.27e-18 0.89438 1 0.11744 1 0.0066898 1 0.0083092 1 0.018628 1 0.0024592 1 0.19245 1 0.095287 1 del_18q23 278 (54%) 233 6.4219e-23 4.63e-20 4.703e-22 3.38e-19 0.25472 1 0.0082623 1 0.0051287 1 0.0030921 1 0.024253 1 0.0043499 1 0.075053 1 0.1797 1 del_19p13.3 165 (32%) 346 6.7636e-08 4.41e-05 7.2885e-07 0.000463 0.4428 1 0.49852 1 0.020068 1 0.24711 1 0.22063 1 0.010499 1 0.53689 1 0.36731 1 del_19q13.43 94 (18%) 417 7.7352e-07 0.00049 5.6651e-07 0.000361 0.32665 1 1 1 0.86469 1 0.65371 1 0.6209 1 0.40705 1 0.60212 1 0.78132 1 del_21q22.3 195 (38%) 316 9.4932e-15 6.54e-12 2.6474e-10 1.77e-07 0.60914 1 0.33362 1 0.045595 1 0.14336 1 0.61086 1 0.073033 1 0.91387 1 0.2699 1 del_22q13.31 84 (16%) 427 0.0010131 0.577 0.0094807 1 0.68418 1 0.94806 1 0.019696 1 0.8441 1 0.011616 1 0.31928 1 0.13017 1 0.7256 1 del_xp22.2 152 (30%) 359 3.9347e-08 2.58e-05 1.2684e-09 8.43e-07 0.31595 1 0.16271 1 0.087114 1 0.24225 1 0.017572 1 0.54647 1 0.38769 1 0.86809 1 del_xp21.3 154 (30%) 357 6.1224e-09 4.05e-06 2.7389e-06 0.00171 0.55614 1 0.60705 1 0.46883 1 0.10632 1 0.21039 1 0.42232 1 0.73841 1 0.86531 1 del_xq21.33 74 (14%) 437 6.159e-06 0.0038 3.5159e-07 0.000225 0.48692 1 0.23732 1 0.0008579 0.492 0.0061436 1 9.5749e-05 0.0569 0.035999 1 0.22181 1 0.012552 1