Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
PIK3CA	64 (21%)	242	0.029209	1	0.064588	1	0.70167	1	0.88079	1	0.09561	1	0.46783	1	0.0088635	1	0.15479	1	0.080348	1	0.26497	1
CDKN2A	65 (21%)	241	0.085736	1	0.0050802	1	0.0012026	0.393	0.30736	1	0.1834	1	0.2126	1	0.37117	1	0.062329	1	0.36837	1	0.31804	1
HRAS	10 (3%)	296	0.00021102	0.0709	0.010901	1	0.38923	1	0.23445	1	0.0013096	0.427	0.0028564	0.914	0.54144	1	0.052137	1	0.75688	1	0.41383	1
TP53	213 (70%)	93	1.6536e-11	5.72e-09	1.7473e-19	6.06e-17	0.085796	1	0.062787	1	0.0084705	1	0.00019936	0.0672	0.024338	1	0.00022022	0.0736	0.086689	1	0.012923	1
NFE2L2	17 (6%)	289	0.88228	1	0.00022843	0.0761	0.34776	1	1	1	1	1	0.75545	1	0.28694	1	1	1	0.30092	1	0.69724	1
NOTCH1	57 (19%)	249	0.22921	1	0.0063753	1	0.057686	1	0.026686	1	0.0019526	0.627	0.00026681	0.0886	3.2568e-05	0.011	0.23029	1	0.018531	1	0.020898	1
NSD1	33 (11%)	273	0.032692	1	4.4735e-24	1.56e-21	0.097422	1	0.45874	1	0.00029157	0.0965	6.0375e-05	0.0204	0.014412	1	0.0047661	1	0.03866	1	0.027993	1
FAT1	69 (23%)	237	0.33415	1	0.06289	1	0.90528	1	1	1	0.1087	1	0.21922	1	0.096939	1	0.40161	1	0.85889	1	0.1308	1
CASP8	27 (9%)	279	2.0712e-05	0.00704	7.5494e-11	2.6e-08	0.016809	1	0.31125	1	1.618e-08	5.57e-06	2.849e-06	0.000974	0.14353	1	0.83816	1	0.49344	1	0.0018222	0.587
JUB	18 (6%)	288	0.42402	1	0.15071	1	0.39679	1	0.46555	1	0.12666	1	0.18983	1	0.077904	1	1	1	0.041057	1	1	1
MLL2	53 (17%)	253	0.011374	1	0.044973	1	0.49985	1	0.81142	1	0.082009	1	0.064114	1	0.07056	1	0.0049862	1	0.093872	1	0.032881	1
FBXW7	15 (5%)	291	0.667	1	0.13783	1	0.41645	1	0.13392	1	0.65295	1	0.43762	1	0.79359	1	0.6021	1	1	1	1	1
ZNF750	13 (4%)	293	0.44537	1	0.13064	1	0.80492	1	0.52629	1	0.079331	1	0.099988	1	0.75527	1	1	1	0.37026	1	0.81732	1
EPHA2	13 (4%)	293	0.55409	1	0.0015788	0.512	0.74122	1	0.90154	1	0.063102	1	0.22835	1	0.32343	1	0.23911	1	0.72539	1	0.027483	1
FLG	47 (15%)	259	0.36692	1	0.15014	1	0.54762	1	0.76207	1	0.064257	1	0.22169	1	0.056657	1	0.10781	1	0.10467	1	0.025432	1
B2M	7 (2%)	299	0.10952	1	0.06349	1	NA	NA	NA	NA	0.5838	1	0.38268	1	0.28553	1	0.70462	1	0.76401	1	0.84712	1
EP300	24 (8%)	282	0.23487	1	0.3881	1	0.57326	1	0.27816	1	0.004822	1	0.1134	1	0.42369	1	0.37912	1	1	1	0.65047	1
RHOA	4 (1%)	302	0.23491	1	0.12241	1	0.13771	1	0.44934	1	0.82349	1	0.156	1	0.076874	1	0.30813	1	0.11436	1	0.060364	1
HLA-A	9 (3%)	297	0.075879	1	0.13185	1	1	1	0.45294	1	0.18852	1	0.69692	1	0.20179	1	0.31842	1	0.54084	1	0.78129	1
CTCF	11 (4%)	295	0.27567	1	0.016435	1	0.61574	1	0.85648	1	0.42577	1	0.92846	1	0.7931	1	0.76314	1	0.46993	1	0.41383	1
RB1	10 (3%)	296	0.0077124	1	0.38053	1	0.3271	1	0.12253	1	0.055842	1	0.25889	1	0.14328	1	1	1	0.42379	1	0.78129	1
CSMD3	70 (23%)	236	0.0010511	0.345	0.00021726	0.0728	0.013041	1	0.15033	1	8.2605e-06	0.00282	1.4096e-06	0.000483	0.00051494	0.17	0.0013819	0.449	0.0017652	0.57	0.00097437	0.321
TGFBR2	10 (3%)	296	0.16256	1	0.014766	1	0.43789	1	1	1	0.22912	1	0.92116	1	1	1	1	1	0.66188	1	0.027483	1
NECAB1	6 (2%)	300	0.9143	1	0.17582	1	0.87231	1	0.65911	1	0.071498	1	0.099173	1	0.50513	1	0.40662	1	0.53538	1	0.27908	1
MAPK1	4 (1%)	302	0.1302	1	0.85609	1	1	1	0.74281	1	0.6886	1	0.68989	1	0.34201	1	1	1	0.49918	1	0.52671	1
EPB41L3	16 (5%)	290	0.07277	1	0.025719	1	0.6751	1	0.12819	1	0.071668	1	0.0088908	1	0.25277	1	0.072436	1	0.13049	1	0.36157	1
RAC1	9 (3%)	297	0.078887	1	0.49032	1	1	1	0.74281	1	0.18852	1	0.22229	1	0.25064	1	0.087889	1	0.32608	1	0.33346	1
CUL3	10 (3%)	296	0.30432	1	0.12316	1	0.37653	1	0.19932	1	0.46861	1	0.78661	1	0.91754	1	0.32648	1	0.18487	1	0.37818	1
PRB1	7 (2%)	299	0.15673	1	0.14672	1	0.35663	1	0.65911	1	0.80383	1	0.5711	1	0.24377	1	1	1	0.073595	1	0.36257	1
TRPV4	7 (2%)	299	0.66072	1	0.9221	1	1	1	1	1	0.49412	1	0.30576	1	0.37717	1	0.24703	1	0.76401	1	0.39528	1
EPDR1	6 (2%)	300	0.70384	1	0.35959	1	0.71413	1	0.77307	1	0.33143	1	0.68557	1	1	1	0.69079	1	0.16753	1	1	1
SLC26A7	8 (3%)	298	0.88667	1	0.50958	1	0.39401	1	0.28899	1	0.12824	1	0.39861	1	0.80919	1	0.47926	1	0.67238	1	0.17539	1
KCNA3	8 (3%)	298	0.34206	1	0.80149	1	0.045173	1	0.59184	1	0.60321	1	0.44592	1	0.80919	1	0.47926	1	0.6393	1	0.064405	1
HIST1H1B	7 (2%)	299	0.44313	1	0.0063221	1	0.94457	1	0.64842	1	0.64149	1	0.26665	1	0.78598	1	0.70462	1	1	1	0.015601	1
STEAP4	10 (3%)	296	0.49542	1	0.60143	1	0.17149	1	0.11962	1	0.10786	1	0.33947	1	0.23942	1	0.74532	1	0.51518	1	0.89762	1