Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.001 0.106 0.315 47.0 -9999.0 0.0 47.0 KIRREL 0.002 0.099 -9999.0 0.0 -0.448 22.0 22.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.001 0.106 -9999.0 0.0 -0.315 47.0 47.0 PLCG1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.024 0.097 -9999.0 0.0 -0.298 23.0 23.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.002 0.061 -9999.0 0.0 -0.253 19.0 19.0 FYN -0.016 0.085 0.271 9.0 -0.278 23.0 32.0 mol:Ca2+ 0.023 0.094 -9999.0 0.0 -0.296 21.0 21.0 mol:DAG 0.024 0.095 -9999.0 0.0 -0.297 21.0 21.0 NPHS2 -0.013 0.068 -9999.0 0.0 -0.406 12.0 12.0 mol:IP3 0.024 0.095 -9999.0 0.0 -0.297 21.0 21.0 regulation of endocytosis 0.021 0.084 -9999.0 0.0 -0.27 20.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.011 0.092 -9999.0 0.0 -0.243 52.0 52.0 establishment of cell polarity 0.001 0.106 -9999.0 0.0 -0.315 47.0 47.0 Nephrin/NEPH1/podocin/NCK1-2 0.033 0.09 -9999.0 0.0 -0.287 17.0 17.0 Nephrin/NEPH1/beta Arrestin2 0.023 0.085 -9999.0 0.0 -0.273 20.0 20.0 NPHS1 -0.02 0.1 -9999.0 0.0 -0.404 29.0 29.0 Nephrin/NEPH1/podocin 0.015 0.085 -9999.0 0.0 -0.275 24.0 24.0 TJP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.025 0.096 -9999.0 0.0 -0.299 21.0 21.0 CD2AP 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.025 0.098 -9999.0 0.0 -0.3 23.0 23.0 GRB2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.03 0.096 0.28 7.0 -0.251 50.0 57.0 cytoskeleton organization -0.01 0.071 0.231 3.0 -0.293 18.0 21.0 Nephrin/NEPH1 0.006 0.075 -9999.0 0.0 -0.218 46.0 46.0 Nephrin/NEPH1/ZO-1 0.019 0.091 -9999.0 0.0 -0.251 46.0 46.0