Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.032 -9999.0 0.0 -0.26 5.0 5.0 epithelial cell differentiation 0.048 0.034 -9999.0 0.0 -0.231 3.0 3.0 CYFIP2 0.025 0.029 -9999.0 0.0 -0.421 2.0 2.0 ENAH 0.019 0.071 0.233 11.0 -0.45 1.0 12.0 EGFR 0.02 0.048 -9999.0 0.0 -0.449 5.0 5.0 EPHA2 0.02 0.057 -9999.0 0.0 -0.449 7.0 7.0 MYO6 0.017 0.037 0.204 3.0 -9999.0 0.0 3.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.027 -9999.0 0.0 -0.253 2.0 2.0 AQP5 -0.273 0.216 -9999.0 0.0 -0.448 273.0 273.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.017 0.036 0.209 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.062 0.189 2.0 -9999.0 0.0 2.0 EGF -0.059 0.182 -9999.0 0.0 -0.448 88.0 88.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.086 0.185 -9999.0 0.0 -0.422 108.0 108.0 cortical microtubule organization 0.048 0.034 -9999.0 0.0 -0.231 3.0 3.0 GO:0000145 -0.001 0.036 0.192 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.036 -9999.0 0.0 -0.233 3.0 3.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.013 0.028 -9999.0 0.0 -0.386 1.0 1.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.043 -9999.0 0.0 -0.248 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.008 0.029 0.202 2.0 -9999.0 0.0 2.0 PVRL2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.017 0.035 0.211 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.056 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.022 0.048 -9999.0 0.0 -0.449 5.0 5.0 EGFR/EGFR/EGF/EGF -0.005 0.102 -9999.0 0.0 -0.377 5.0 5.0 RhoA/GDP 0.05 0.033 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.002 0.036 0.188 3.0 -9999.0 0.0 3.0 IGF-1R heterotetramer 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.053 0.178 -9999.0 0.0 -0.447 84.0 84.0 DIAPH1 0.017 0.121 -9999.0 0.0 -0.553 1.0 1.0 Wnt receptor signaling pathway -0.048 0.034 0.231 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.028 -9999.0 0.0 -0.386 1.0 1.0 CTNNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.002 0.037 0.19 3.0 -9999.0 0.0 3.0 EFNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.003 0.03 0.18 8.0 -9999.0 0.0 8.0 Ephrin A1/EPHA2 0.039 0.045 -9999.0 0.0 -0.42 1.0 1.0 SEC6/SEC8 0.01 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.001 0.062 0.191 2.0 -9999.0 0.0 2.0 HGF/MET 0.03 0.063 -9999.0 0.0 -0.36 2.0 2.0 HGF 0.007 0.092 -9999.0 0.0 -0.435 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.032 -9999.0 0.0 -0.262 5.0 5.0 actin cable formation 0.058 0.095 0.226 82.0 -0.32 1.0 83.0 KIAA1543 -0.014 0.063 0.194 4.0 -0.4 3.0 7.0 KIFC3 0.014 0.029 0.191 1.0 -9999.0 0.0 1.0 NCK1 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.017 0.035 0.201 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.034 -9999.0 0.0 -0.231 3.0 3.0 EXOC4 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.018 0.036 0.201 4.0 -9999.0 0.0 4.0 PIP5K1C 0.018 0.036 0.211 2.0 -9999.0 0.0 2.0 LIMA1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.025 0.078 0.255 13.0 -0.342 1.0 14.0 adherens junction assembly -0.01 0.096 0.279 6.0 -0.5 8.0 14.0 IGF-1R heterotetramer/IGF1 0.003 0.098 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.049 -9999.0 0.0 -0.412 6.0 6.0 PLEKHA7 0.003 0.069 0.211 2.0 -0.419 3.0 5.0 mol:GTP 0.051 0.042 -9999.0 0.0 -0.247 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.025 0.084 0.324 15.0 -9999.0 0.0 15.0 cortical actin cytoskeleton stabilization 0.021 0.032 -9999.0 0.0 -0.26 5.0 5.0 regulation of cell-cell adhesion -0.002 0.036 0.188 3.0 -9999.0 0.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.032 -9999.0 0.0 -0.262 5.0 5.0