Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	374.0	2996.0	8.0	-0.843	0.217	1000.0	-1000.0	-0.035	-1000.0
HIF-1-alpha transcription factor network	200.0	15233.0	76.0	-1.334	0.026	1000.0	-1000.0	-0.177	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	172.0	5853.0	34.0	-0.608	0.016	1000.0	-1000.0	-0.109	-1000.0
TCR signaling in naïve CD8+ T cells	146.0	13655.0	93.0	-0.659	0.329	1000.0	-1000.0	-0.115	-1000.0
TCGA08_p53	142.0	999.0	7.0	-0.654	0.313	1000.0	-1000.0	-0.018	-1000.0
Aurora B signaling	120.0	8050.0	67.0	-0.408	0.016	1000.0	-1000.0	-0.104	-1000.0
Syndecan-4-mediated signaling events	118.0	7939.0	67.0	-0.646	0.109	1000.0	-1000.0	-0.135	-1000.0
FOXA2 and FOXA3 transcription factor networks	117.0	5387.0	46.0	-1.225	0.025	1000.0	-1000.0	-0.083	-1000.0
IL12-mediated signaling events	107.0	9314.0	87.0	-0.701	0.165	1000.0	-1000.0	-0.157	-1000.0
FOXM1 transcription factor network	106.0	5441.0	51.0	-0.825	0.04	1000.0	-1000.0	-0.189	-1000.0
Glypican 1 network	103.0	4964.0	48.0	-0.56	0.045	1000.0	-1000.0	-0.08	-1000.0
PDGFR-alpha signaling pathway	101.0	4486.0	44.0	-0.275	0.034	1000.0	-1000.0	-0.09	-1000.0
amb2 Integrin signaling	84.0	6921.0	82.0	-0.555	0.016	1000.0	-1000.0	-0.113	-1000.0
JNK signaling in the CD4+ TCR pathway	82.0	1401.0	17.0	-0.415	0.016	1000.0	-1000.0	-0.085	-1000.0
IL4-mediated signaling events	76.0	6996.0	91.0	-0.838	0.542	1000.0	-1000.0	-0.172	-1000.0
EGFR-dependent Endothelin signaling events	72.0	1522.0	21.0	-0.67	0.016	1000.0	-1000.0	-0.111	-1000.0
Caspase cascade in apoptosis	69.0	5167.0	74.0	-0.328	0.162	1000.0	-1000.0	-0.083	-1000.0
Aurora C signaling	69.0	489.0	7.0	-0.397	0.012	1000.0	-1000.0	-0.06	-1000.0
VEGFR1 specific signals	69.0	3897.0	56.0	-0.47	0.046	1000.0	-1000.0	-0.115	-1000.0
Glypican 2 network	68.0	272.0	4.0	-0.123	-1000.0	1000.0	-1000.0	-0.051	-1000.0
HIF-2-alpha transcription factor network	66.0	2841.0	43.0	-0.762	0.339	1000.0	-1000.0	-0.112	-1000.0
Syndecan-1-mediated signaling events	64.0	2186.0	34.0	-0.416	0.016	1000.0	-1000.0	-0.109	-1000.0
IL23-mediated signaling events	59.0	3584.0	60.0	-0.397	0.021	1000.0	-1000.0	-0.191	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	59.0	1958.0	33.0	-0.832	0.016	1000.0	-1000.0	-0.085	-1000.0
BMP receptor signaling	58.0	4741.0	81.0	-0.698	0.016	1000.0	-1000.0	-0.127	-1000.0
Signaling events mediated by the Hedgehog family	48.0	2537.0	52.0	-0.443	0.119	1000.0	-1000.0	-0.13	-1000.0
Fc-epsilon receptor I signaling in mast cells	44.0	4343.0	97.0	-0.325	0.04	1000.0	-1000.0	-0.132	-1000.0
IL27-mediated signaling events	42.0	2144.0	51.0	-0.61	0.078	1000.0	-1000.0	-0.114	-1000.0
Effects of Botulinum toxin	41.0	1072.0	26.0	-0.369	0.016	1000.0	-1000.0	-0.087	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	41.0	2813.0	68.0	-0.549	0.064	1000.0	-1000.0	-0.179	-1000.0
Ephrin A  reverse signaling	39.0	277.0	7.0	-0.057	-0.0	1000.0	-1000.0	-0.043	-1000.0
Arf6 signaling events	37.0	2354.0	62.0	-0.67	0.016	1000.0	-1000.0	-0.09	-1000.0
p75(NTR)-mediated signaling	37.0	4734.0	125.0	-0.418	0.016	1000.0	-1000.0	-0.148	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1175.0	31.0	-0.463	0.016	1000.0	-1000.0	-0.153	-1000.0
IL2 signaling events mediated by STAT5	34.0	760.0	22.0	-0.445	0.038	1000.0	-1000.0	-0.073	-1000.0
BCR signaling pathway	34.0	3439.0	99.0	-0.343	0.035	1000.0	-1000.0	-0.127	-1000.0
LPA4-mediated signaling events	33.0	402.0	12.0	-0.165	0.026	1000.0	-1000.0	-0.035	-1000.0
IL2 signaling events mediated by PI3K	33.0	1948.0	58.0	-0.443	0.031	1000.0	-1000.0	-0.115	-1000.0
Coregulation of Androgen receptor activity	30.0	2287.0	76.0	-0.922	0.033	1000.0	-1000.0	-0.071	-1000.0
PLK1 signaling events	30.0	2603.0	85.0	-0.382	0.016	1000.0	-1000.0	-0.086	-1000.0
Glucocorticoid receptor regulatory network	29.0	3405.0	114.0	-0.413	0.16	1000.0	-1000.0	-0.1	-1000.0
S1P1 pathway	29.0	1056.0	36.0	-0.38	0.018	1000.0	-1000.0	-0.102	-1000.0
IL6-mediated signaling events	29.0	2226.0	75.0	-0.284	0.076	1000.0	-1000.0	-0.118	-1000.0
Regulation of Telomerase	29.0	2998.0	102.0	-0.67	0.051	1000.0	-1000.0	-0.148	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	28.0	1516.0	54.0	-0.658	0.031	1000.0	-1000.0	-0.131	-1000.0
Integrins in angiogenesis	26.0	2264.0	84.0	-0.38	0.039	1000.0	-1000.0	-0.143	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	25.0	1965.0	78.0	-0.315	0.045	1000.0	-1000.0	-0.102	-1000.0
Aurora A signaling	24.0	1458.0	60.0	-0.244	0.053	1000.0	-1000.0	-0.089	-1000.0
Visual signal transduction: Rods	24.0	1253.0	52.0	-0.291	0.016	1000.0	-1000.0	-0.118	-1000.0
Reelin signaling pathway	23.0	1296.0	56.0	-0.238	0.016	1000.0	-1000.0	-0.111	-1000.0
Angiopoietin receptor Tie2-mediated signaling	23.0	2043.0	88.0	-0.319	0.074	1000.0	-1000.0	-0.145	-1000.0
Signaling events mediated by PTP1B	22.0	1725.0	76.0	-0.673	0.049	1000.0	-1000.0	-0.113	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	22.0	1000.0	45.0	-0.576	0.061	1000.0	-1000.0	-0.123	-1000.0
Syndecan-2-mediated signaling events	20.0	1415.0	69.0	-0.555	0.054	1000.0	-1000.0	-0.089	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	20.0	2465.0	120.0	-0.166	0.143	1000.0	-1000.0	-0.118	-1000.0
Endothelins	19.0	1908.0	96.0	-0.348	0.088	1000.0	-1000.0	-0.115	-1000.0
Regulation of nuclear SMAD2/3 signaling	17.0	2410.0	136.0	-0.451	0.1	1000.0	-1000.0	-0.112	-1000.0
EPO signaling pathway	17.0	975.0	55.0	-0.287	0.018	1000.0	-1000.0	-0.147	-1000.0
Wnt signaling	17.0	123.0	7.0	-0.07	0.016	1000.0	-1000.0	-0.077	-1000.0
Thromboxane A2 receptor signaling	16.0	1730.0	105.0	-0.67	0.066	1000.0	-1000.0	-0.102	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	1011.0	61.0	-0.188	0.093	1000.0	-1000.0	-0.108	-1000.0
S1P3 pathway	16.0	698.0	42.0	-0.376	0.062	1000.0	-1000.0	-0.084	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	15.0	590.0	37.0	-0.295	0.026	1000.0	-1000.0	-0.125	-1000.0
FoxO family signaling	15.0	980.0	64.0	-0.569	0.122	1000.0	-1000.0	-0.103	-1000.0
LPA receptor mediated events	15.0	1619.0	102.0	-0.404	0.061	1000.0	-1000.0	-0.124	-1000.0
Sphingosine 1-phosphate (S1P) pathway	14.0	402.0	28.0	-0.134	0.025	1000.0	-1000.0	-0.086	-1000.0
PLK2 and PLK4 events	14.0	42.0	3.0	-0.015	0.011	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	14.0	1134.0	76.0	-0.67	0.232	1000.0	-1000.0	-0.099	-1000.0
Canonical Wnt signaling pathway	14.0	727.0	51.0	-0.188	0.096	1000.0	-1000.0	-0.086	-1000.0
FAS signaling pathway (CD95)	13.0	638.0	47.0	-0.43	0.028	1000.0	-1000.0	-0.069	-1000.0
Class I PI3K signaling events	13.0	998.0	73.0	-0.461	0.036	1000.0	-1000.0	-0.112	-1000.0
E-cadherin signaling events	13.0	68.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.07	-1000.0
IFN-gamma pathway	12.0	869.0	68.0	-0.382	0.017	1000.0	-1000.0	-0.135	-1000.0
Nongenotropic Androgen signaling	12.0	637.0	52.0	-0.175	0.071	1000.0	-1000.0	-0.087	-1000.0
Regulation of Androgen receptor activity	12.0	896.0	70.0	-0.964	0.04	1000.0	-1000.0	-0.106	-1000.0
ErbB4 signaling events	11.0	818.0	69.0	-0.177	0.105	1000.0	-1000.0	-0.123	-1000.0
S1P5 pathway	11.0	187.0	17.0	-0.134	0.045	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1454.0	125.0	-0.393	0.044	1000.0	-1000.0	-0.149	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	845.0	74.0	-0.67	0.099	1000.0	-1000.0	-0.139	-1000.0
S1P4 pathway	10.0	265.0	25.0	-0.134	0.035	1000.0	-1000.0	-0.076	-1000.0
Visual signal transduction: Cones	9.0	355.0	38.0	-0.041	0.016	1000.0	-1000.0	-0.096	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	-0.019	0.016	1000.0	-1000.0	-0.053	-1000.0
Noncanonical Wnt signaling pathway	8.0	213.0	26.0	-0.114	0.016	1000.0	-1000.0	-0.126	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	667.0	82.0	-0.064	0.027	1000.0	-1000.0	-0.117	-1000.0
TCGA08_rtk_signaling	8.0	232.0	26.0	-0.277	0.041	1000.0	-1000.0	-0.036	-1000.0
Canonical NF-kappaB pathway	6.0	268.0	39.0	-0.193	0.075	1000.0	-1000.0	-0.116	-1000.0
Signaling events mediated by HDAC Class III	6.0	240.0	40.0	-0.059	0.033	1000.0	-1000.0	-0.063	-1000.0
IL1-mediated signaling events	6.0	385.0	62.0	-0.091	0.06	1000.0	-1000.0	-0.144	-1000.0
Signaling events mediated by PRL	6.0	231.0	34.0	-0.056	0.046	1000.0	-1000.0	-0.088	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.006	0.006	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	6.0	270.0	44.0	-0.101	0.049	1000.0	-1000.0	-0.089	-1000.0
ErbB2/ErbB3 signaling events	5.0	382.0	65.0	-0.132	0.059	1000.0	-1000.0	-0.106	-1000.0
Insulin-mediated glucose transport	5.0	183.0	32.0	-0.086	0.067	1000.0	-1000.0	-0.095	-1000.0
Ephrin B reverse signaling	5.0	279.0	48.0	-0.027	0.032	1000.0	-1000.0	-0.109	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	82.0	15.0	-0.0	0.037	1000.0	-1000.0	-0.05	-1000.0
Syndecan-3-mediated signaling events	5.0	205.0	35.0	-0.04	0.016	1000.0	-1000.0	-0.108	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	391.0	76.0	-0.026	0.068	1000.0	-1000.0	-0.116	-1000.0
Arf6 trafficking events	5.0	397.0	71.0	-0.125	0.058	1000.0	-1000.0	-0.1	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	85.0	17.0	-0.037	0.055	1000.0	-1000.0	-0.068	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	368.0	85.0	-0.037	0.079	1000.0	-1000.0	-0.108	-1000.0
Arf6 downstream pathway	4.0	214.0	43.0	-0.033	0.033	1000.0	-1000.0	-0.059	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	146.0	36.0	-0.026	0.031	1000.0	-1000.0	-0.104	-1000.0
EPHB forward signaling	4.0	360.0	85.0	-0.074	0.07	1000.0	-1000.0	-0.135	-1000.0
Plasma membrane estrogen receptor signaling	4.0	345.0	86.0	-0.166	0.072	1000.0	-1000.0	-0.115	-1000.0
BARD1 signaling events	3.0	218.0	57.0	-0.169	0.043	1000.0	-1000.0	-0.104	-1000.0
Cellular roles of Anthrax toxin	3.0	119.0	39.0	-0.022	0.027	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	3.0	162.0	43.0	-0.292	0.054	1000.0	-1000.0	-0.116	-1000.0
Osteopontin-mediated events	2.0	113.0	38.0	-0.03	0.099	1000.0	-1000.0	-0.153	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	130.0	65.0	-0.062	0.093	1000.0	-1000.0	-0.093	-1000.0
ceramide signaling pathway	2.0	126.0	49.0	-0.12	0.054	1000.0	-1000.0	-0.071	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	128.0	52.0	-0.031	0.093	1000.0	-1000.0	-0.096	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	176.0	83.0	-0.086	0.081	1000.0	-1000.0	-0.111	-1000.0
Retinoic acid receptors-mediated signaling	2.0	122.0	58.0	-0.026	0.063	1000.0	-1000.0	-0.11	-1000.0
Regulation of p38-alpha and p38-beta	2.0	148.0	54.0	-0.041	0.073	1000.0	-1000.0	-0.083	-1000.0
Insulin Pathway	2.0	207.0	74.0	-0.034	0.055	1000.0	-1000.0	-0.137	-1000.0
PDGFR-beta signaling pathway	2.0	272.0	97.0	-0.057	0.087	1000.0	-1000.0	-0.129	-1000.0
Signaling events mediated by HDAC Class II	1.0	121.0	75.0	-0.027	0.051	1000.0	-1000.0	-0.095	-1000.0
Circadian rhythm pathway	1.0	33.0	22.0	-0.019	0.064	1000.0	-1000.0	-0.095	-1000.0
mTOR signaling pathway	1.0	70.0	53.0	-0.008	0.044	1000.0	-1000.0	-0.093	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	104.0	68.0	-0.086	0.06	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by HDAC Class I	1.0	202.0	104.0	-0.029	0.064	1000.0	-1000.0	-0.11	-1000.0
Atypical NF-kappaB pathway	1.0	52.0	31.0	-0.021	0.037	1000.0	-1000.0	-0.11	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	57.0	44.0	-0.043	0.051	1000.0	-1000.0	-0.082	-1000.0
IGF1 pathway	1.0	92.0	57.0	-0.065	0.071	1000.0	-1000.0	-0.144	-1000.0
Alternative NF-kappaB pathway	1.0	14.0	13.0	-0.005	0.016	1000.0	-1000.0	-0.091	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	-0.001	0.062	1000.0	-1000.0	-0.096	-1000.0
Nectin adhesion pathway	0.0	61.0	63.0	-0.015	0.08	1000.0	-1000.0	-0.117	-1000.0
TRAIL signaling pathway	0.0	29.0	48.0	-0.002	0.071	1000.0	-1000.0	-0.101	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.081	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.005	0.016	1000.0	-1000.0	-0.07	-1000.0
Arf1 pathway	0.0	31.0	54.0	-0.01	0.043	1000.0	-1000.0	-0.071	-1000.0
Total	4156	218451	7203	-40.1476637427	-991.817853551	131000	-131000	-13.5188711169	-131000