E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.124 -9999.0 0.0 -0.477 16.0 16.0 KLHL20 0.022 0.076 0.209 2.0 -0.32 2.0 4.0 CYFIP2 0.014 0.078 -9999.0 0.0 -0.635 7.0 7.0 Rac1/GDP 0.023 0.087 0.305 4.0 -0.356 1.0 5.0 ENAH -0.02 0.123 -9999.0 0.0 -0.478 17.0 17.0 AP1M1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.028 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.035 -9999.0 0.0 -0.202 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.038 0.081 -9999.0 0.0 -0.364 16.0 16.0 RAPGEF1 -0.012 0.121 -9999.0 0.0 -0.428 12.0 12.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.129 -9999.0 0.0 -0.494 17.0 17.0 CRK -0.011 0.12 -9999.0 0.0 -0.448 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.03 0.088 -9999.0 0.0 -0.426 15.0 15.0 alphaE/beta7 Integrin 0.042 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.02 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.017 0.119 -9999.0 0.0 -0.478 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.005 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.051 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.007 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.023 0.101 -9999.0 0.0 -0.493 18.0 18.0 TIAM1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.032 0.072 -9999.0 0.0 -0.343 13.0 13.0 AKT1 0.022 0.032 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.031 -9999.0 0.0 -0.635 1.0 1.0 CDH1 0.008 0.117 -9999.0 0.0 -0.617 17.0 17.0 RhoA/GDP 0.04 0.085 0.362 7.0 -9999.0 0.0 7.0 actin cytoskeleton organization 0.023 0.063 0.177 13.0 -0.226 2.0 15.0 CDC42/GDP 0.031 0.108 0.425 10.0 -9999.0 0.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.063 -9999.0 0.0 -0.305 15.0 15.0 ITGB7 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.035 0.077 -9999.0 0.0 -0.363 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.021 0.067 -9999.0 0.0 -0.345 13.0 13.0 mol:GDP 0.02 0.115 0.439 10.0 -0.4 3.0 13.0 CDC42/GTP/IQGAP1 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.051 -9999.0 0.0 -0.635 3.0 3.0 p120 catenin/RhoA/GDP 0.019 0.081 0.308 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.063 0.183 12.0 -0.217 18.0 30.0 NME1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.022 0.124 -9999.0 0.0 -0.483 16.0 16.0 regulation of cell-cell adhesion 0.014 0.042 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.031 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.034 0.066 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.086 -9999.0 0.0 -0.661 1.0 1.0 CCND1 0.021 0.074 0.204 8.0 -0.272 18.0 26.0 VAV2 -0.018 0.161 -9999.0 0.0 -0.556 17.0 17.0 RAP1/GDP 0.043 0.077 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.02 0.121 -9999.0 0.0 -0.467 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.048 0.09 -9999.0 0.0 -0.636 1.0 1.0 E-cadherin/beta catenin -0.0 0.077 -9999.0 0.0 -0.408 17.0 17.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.122 -9999.0 0.0 -0.473 16.0 16.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 Rac1/GTP -0.032 0.079 -9999.0 0.0 -0.401 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.024 0.078 -9999.0 0.0 -0.399 13.0 13.0 ITGAE 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.132 -9999.0 0.0 -0.505 17.0 17.0