Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.394 0.232 0.525 379.0 -9999.0 0.0 379.0 KIRREL -0.058 0.084 -9999.0 0.0 -0.624 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.394 0.233 -9999.0 0.0 -0.526 379.0 379.0 PLCG1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.028 0.033 -9999.0 0.0 -0.706 1.0 1.0 WASL 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.414 0.28 -9999.0 0.0 -0.537 400.0 400.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.34 0.235 -9999.0 0.0 -0.565 224.0 224.0 FYN -0.398 0.255 0.265 1.0 -0.506 400.0 401.0 mol:Ca2+ -0.406 0.277 -9999.0 0.0 -0.529 398.0 398.0 mol:DAG -0.408 0.279 -9999.0 0.0 -0.532 398.0 398.0 NPHS2 -0.338 0.326 -9999.0 0.0 -0.688 235.0 235.0 mol:IP3 -0.408 0.279 -9999.0 0.0 -0.532 398.0 398.0 regulation of endocytosis -0.37 0.249 -9999.0 0.0 -0.621 211.0 211.0 Nephrin/NEPH1/podocin/Cholesterol -0.42 0.277 -9999.0 0.0 -0.538 404.0 404.0 establishment of cell polarity -0.394 0.232 -9999.0 0.0 -0.525 379.0 379.0 Nephrin/NEPH1/podocin/NCK1-2 -0.377 0.269 -9999.0 0.0 -0.648 209.0 209.0 Nephrin/NEPH1/beta Arrestin2 -0.376 0.254 -9999.0 0.0 -0.632 211.0 211.0 NPHS1 -0.512 0.284 -9999.0 0.0 -0.666 392.0 392.0 Nephrin/NEPH1/podocin -0.396 0.264 -9999.0 0.0 -0.508 404.0 404.0 TJP1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 NCK2 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.41 0.281 -9999.0 0.0 -0.535 398.0 398.0 CD2AP 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.412 0.281 -9999.0 0.0 -0.538 395.0 395.0 GRB2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.389 0.255 0.276 1.0 -0.499 397.0 398.0 cytoskeleton organization -0.43 0.285 -9999.0 0.0 -0.586 349.0 349.0 Nephrin/NEPH1 -0.286 0.174 -9999.0 0.0 -0.384 379.0 379.0 Nephrin/NEPH1/ZO-1 -0.315 0.2 -9999.0 0.0 -0.428 377.0 377.0