Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.181 0.192 -9999.0 0.0 -0.583 32.0 32.0 IHH -0.08 0.194 -9999.0 0.0 -0.686 44.0 44.0 SHH Np/Cholesterol/GAS1 0.004 0.098 -9999.0 0.0 -0.372 29.0 29.0 LRPAP1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.004 0.097 0.37 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.086 0.149 -9999.0 0.0 -0.515 26.0 26.0 SMO -0.097 0.148 -9999.0 0.0 -0.538 25.0 25.0 AKT1 -0.037 0.112 -9999.0 0.0 -0.51 14.0 14.0 ARRB2 0.028 0.033 -9999.0 0.0 -0.706 1.0 1.0 BOC 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.096 0.146 -9999.0 0.0 -0.53 25.0 25.0 STIL -0.07 0.133 -9999.0 0.0 -0.428 27.0 27.0 DHH N/PTCH2 0.008 0.124 -9999.0 0.0 -0.442 35.0 35.0 DHH N/PTCH1 -0.106 0.151 -9999.0 0.0 -0.488 35.0 35.0 PIK3CA 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 DHH 0.015 0.097 -9999.0 0.0 -0.635 11.0 11.0 PTHLH -0.283 0.271 -9999.0 0.0 -0.795 39.0 39.0 determination of left/right symmetry -0.096 0.146 -9999.0 0.0 -0.53 25.0 25.0 PIK3R1 0.026 0.031 -9999.0 0.0 -0.635 1.0 1.0 skeletal system development -0.281 0.268 -9999.0 0.0 -0.786 39.0 39.0 IHH N/Hhip -0.162 0.252 -9999.0 0.0 -0.532 153.0 153.0 DHH N/Hhip -0.092 0.226 -9999.0 0.0 -0.475 129.0 129.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.096 0.146 -9999.0 0.0 -0.53 25.0 25.0 pancreas development -0.131 0.281 -9999.0 0.0 -0.62 126.0 126.0 HHAT 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.037 0.035 -9999.0 0.0 -0.472 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.149 -9999.0 0.0 -0.583 31.0 31.0 somite specification -0.096 0.146 -9999.0 0.0 -0.53 25.0 25.0 SHH Np/Cholesterol/PTCH1 -0.083 0.128 -9999.0 0.0 -0.438 28.0 28.0 SHH Np/Cholesterol/PTCH2 0.007 0.092 -9999.0 0.0 -0.343 31.0 31.0 SHH Np/Cholesterol/Megalin -0.004 0.117 -9999.0 0.0 -0.406 35.0 35.0 SHH 0.011 0.069 -9999.0 0.0 -0.469 10.0 10.0 catabolic process -0.123 0.156 -9999.0 0.0 -0.52 32.0 32.0 SMO/Vitamin D3 -0.085 0.138 -9999.0 0.0 -0.484 27.0 27.0 SHH Np/Cholesterol/Hhip -0.067 0.175 -9999.0 0.0 -0.382 112.0 112.0 LRP2 -0.022 0.173 -9999.0 0.0 -0.589 42.0 42.0 receptor-mediated endocytosis -0.098 0.162 -9999.0 0.0 -0.646 17.0 17.0 SHH Np/Cholesterol/BOC 0.022 0.057 -9999.0 0.0 -0.364 10.0 10.0 SHH Np/Cholesterol/CDO -0.015 0.121 -9999.0 0.0 -0.34 60.0 60.0 mesenchymal cell differentiation 0.067 0.174 0.379 112.0 -9999.0 0.0 112.0 mol:Vitamin D3 -0.077 0.137 -9999.0 0.0 -0.442 28.0 28.0 IHH N/PTCH2 -0.058 0.164 -9999.0 0.0 -0.463 67.0 67.0 CDON -0.04 0.196 -9999.0 0.0 -0.587 58.0 58.0 IHH N/PTCH1 -0.123 0.158 -9999.0 0.0 -0.526 32.0 32.0 Megalin/LRPAP1 0.004 0.131 -9999.0 0.0 -0.469 34.0 34.0 PTCH2 -0.001 0.133 -9999.0 0.0 -0.587 25.0 25.0 SHH Np/Cholesterol 0.011 0.054 -9999.0 0.0 -0.368 10.0 10.0 PTCH1 -0.123 0.156 -9999.0 0.0 -0.522 32.0 32.0 HHIP -0.132 0.282 -9999.0 0.0 -0.621 126.0 126.0