Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.057 -9999.0 0.0 -0.297 13.0 13.0 epithelial cell differentiation 0.028 0.07 -9999.0 0.0 -0.339 13.0 13.0 CYFIP2 0.014 0.078 -9999.0 0.0 -0.635 7.0 7.0 ENAH 0.063 0.102 0.39 17.0 -9999.0 0.0 17.0 EGFR 0.02 0.068 -9999.0 0.0 -0.595 6.0 6.0 EPHA2 0.028 0.03 -9999.0 0.0 -0.635 1.0 1.0 MYO6 0.058 0.109 0.383 13.0 -0.353 12.0 25.0 CTNNB1 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.059 -9999.0 0.0 -0.401 7.0 7.0 AQP5 -0.108 0.24 -9999.0 0.0 -0.503 116.0 116.0 CTNND1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.061 0.106 0.395 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion 0.051 0.117 0.405 11.0 -0.458 1.0 12.0 EGF -0.566 0.199 -9999.0 0.0 -0.63 460.0 460.0 NCKAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.008 0.157 -9999.0 0.0 -0.538 29.0 29.0 cortical microtubule organization 0.028 0.07 -9999.0 0.0 -0.339 13.0 13.0 GO:0000145 0.052 0.105 0.387 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.032 0.072 -9999.0 0.0 -0.343 13.0 13.0 MLLT4 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.008 0.045 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.042 -9999.0 0.0 -0.367 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.041 0.083 0.375 2.0 -9999.0 0.0 2.0 PVRL2 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.047 0.093 0.36 5.0 -9999.0 0.0 5.0 ARF6/GTP 0.069 0.045 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.007 0.117 -9999.0 0.0 -0.617 17.0 17.0 EGFR/EGFR/EGF/EGF -0.242 0.144 -9999.0 0.0 -0.586 18.0 18.0 RhoA/GDP 0.03 0.067 -9999.0 0.0 -0.325 10.0 10.0 actin cytoskeleton organization 0.051 0.102 0.346 12.0 -0.446 2.0 14.0 IGF-1R heterotetramer 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.03 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.023 0.061 -9999.0 0.0 -0.587 5.0 5.0 DIAPH1 0.032 0.109 -9999.0 0.0 -0.667 7.0 7.0 Wnt receptor signaling pathway -0.028 0.07 0.339 13.0 -9999.0 0.0 13.0 RHOA 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.047 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.013 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.051 0.103 0.349 12.0 -0.458 2.0 14.0 EFNA1 0.027 0.028 -9999.0 0.0 -0.587 1.0 1.0 LPP 0.046 0.094 0.39 6.0 -9999.0 0.0 6.0 Ephrin A1/EPHA2 0.024 0.064 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.002 0.049 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.052 0.118 0.407 11.0 -0.467 1.0 12.0 HGF/MET 0.013 0.09 -9999.0 0.0 -0.593 3.0 3.0 HGF 0.002 0.122 -9999.0 0.0 -0.596 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.058 -9999.0 0.0 -0.3 13.0 13.0 actin cable formation 0.106 0.13 0.333 72.0 -9999.0 0.0 72.0 KIAA1543 0.048 0.105 0.355 10.0 -0.528 2.0 12.0 KIFC3 0.05 0.093 -9999.0 0.0 -0.328 11.0 11.0 NCK1 0.027 0.03 -9999.0 0.0 -0.635 1.0 1.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.052 0.1 0.43 7.0 -9999.0 0.0 7.0 NCK1/GIT1 0.04 0.026 -9999.0 0.0 -0.472 1.0 1.0 mol:GDP 0.028 0.07 -9999.0 0.0 -0.339 13.0 13.0 EXOC4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.05 0.091 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.062 0.108 0.397 13.0 -9999.0 0.0 13.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.075 0.112 0.411 19.0 -9999.0 0.0 19.0 adherens junction assembly 0.072 0.135 0.507 16.0 -0.711 2.0 18.0 IGF-1R heterotetramer/IGF1 0.023 0.069 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.04 -9999.0 0.0 -0.587 2.0 2.0 PLEKHA7 0.058 0.107 0.362 10.0 -0.554 2.0 12.0 mol:GTP 0.063 0.041 -9999.0 0.0 -0.365 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.083 0.125 0.38 46.0 -9999.0 0.0 46.0 cortical actin cytoskeleton stabilization 0.013 0.057 -9999.0 0.0 -0.297 13.0 13.0 regulation of cell-cell adhesion 0.051 0.102 0.346 12.0 -0.446 2.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.058 -9999.0 0.0 -0.3 13.0 13.0