Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	227.0	7728.0	34.0	-0.512	0.03	1000.0	-1000.0	-0.057	-1000.0
HIF-1-alpha transcription factor network	192.0	14658.0	76.0	-1.099	0.046	1000.0	-1000.0	-0.13	-1000.0
TCR signaling in naïve CD8+ T cells	138.0	12867.0	93.0	-0.435	0.203	1000.0	-1000.0	-0.082	-1000.0
FOXA2 and FOXA3 transcription factor networks	127.0	5845.0	46.0	-1.097	0.036	1000.0	-1000.0	-0.098	-1000.0
TCGA08_retinoblastoma	113.0	911.0	8.0	-0.576	0.16	1000.0	-1000.0	-0.007	-1000.0
PDGFR-alpha signaling pathway	111.0	4923.0	44.0	-0.224	0.037	1000.0	-1000.0	-0.04	-1000.0
Syndecan-4-mediated signaling events	104.0	7033.0	67.0	-0.436	0.088	1000.0	-1000.0	-0.052	-1000.0
Aurora B signaling	92.0	6227.0	67.0	-0.259	0.042	1000.0	-1000.0	-0.044	-1000.0
IL12-mediated signaling events	91.0	7925.0	87.0	-0.449	0.115	1000.0	-1000.0	-0.108	-1000.0
TCGA08_p53	89.0	629.0	7.0	-0.421	0.221	1000.0	-1000.0	-0.014	-1000.0
EGFR-dependent Endothelin signaling events	83.0	1750.0	21.0	-0.566	0.043	1000.0	-1000.0	-0.063	-1000.0
Glypican 1 network	82.0	3941.0	48.0	-0.399	0.046	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	78.0	6427.0	82.0	-0.452	0.038	1000.0	-1000.0	-0.052	-1000.0
FOXM1 transcription factor network	74.0	3794.0	51.0	-0.563	0.031	1000.0	-1000.0	-0.11	-1000.0
BMP receptor signaling	71.0	5755.0	81.0	-0.528	0.054	1000.0	-1000.0	-0.09	-1000.0
Aurora C signaling	68.0	477.0	7.0	-0.261	0.027	1000.0	-1000.0	-0.016	-1000.0
Glypican 2 network	61.0	244.0	4.0	-0.04	-1000.0	1000.0	-1000.0	-0.006	-1000.0
IL4-mediated signaling events	57.0	5237.0	91.0	-0.787	0.489	1000.0	-1000.0	-0.106	-1000.0
Caspase cascade in apoptosis	55.0	4076.0	74.0	-0.289	0.094	1000.0	-1000.0	-0.052	-1000.0
Syndecan-1-mediated signaling events	52.0	1776.0	34.0	-0.251	0.03	1000.0	-1000.0	-0.058	-1000.0
JNK signaling in the CD4+ TCR pathway	51.0	869.0	17.0	-0.221	0.03	1000.0	-1000.0	-0.048	-1000.0
HIF-2-alpha transcription factor network	50.0	2169.0	43.0	-0.527	0.247	1000.0	-1000.0	-0.066	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	50.0	1678.0	33.0	-0.569	0.055	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	49.0	4779.0	97.0	-0.236	0.041	1000.0	-1000.0	-0.082	-1000.0
Reelin signaling pathway	39.0	2190.0	56.0	-0.172	0.08	1000.0	-1000.0	-0.054	-1000.0
Effects of Botulinum toxin	38.0	1003.0	26.0	-0.235	0.04	1000.0	-1000.0	-0.033	-1000.0
Arf6 signaling events	37.0	2307.0	62.0	-0.566	0.065	1000.0	-1000.0	-0.048	-1000.0
Calcium signaling in the CD4+ TCR pathway	37.0	1160.0	31.0	-0.373	0.029	1000.0	-1000.0	-0.066	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	35.0	1890.0	54.0	-0.444	0.042	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by the Hedgehog family	35.0	1857.0	52.0	-0.283	0.067	1000.0	-1000.0	-0.062	-1000.0
IL27-mediated signaling events	33.0	1706.0	51.0	-0.591	0.06	1000.0	-1000.0	-0.057	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	33.0	2283.0	68.0	-0.329	0.058	1000.0	-1000.0	-0.098	-1000.0
PLK1 signaling events	32.0	2766.0	85.0	-0.191	0.043	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	32.0	712.0	22.0	-0.297	0.036	1000.0	-1000.0	-0.054	-1000.0
IL23-mediated signaling events	32.0	1942.0	60.0	-0.261	0.03	1000.0	-1000.0	-0.083	-1000.0
Ephrin A  reverse signaling	31.0	217.0	7.0	-0.023	0.012	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	31.0	3909.0	125.0	-0.305	0.079	1000.0	-1000.0	-0.098	-1000.0
LPA4-mediated signaling events	30.0	366.0	12.0	-0.103	0.011	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	29.0	2279.0	76.0	-0.848	0.055	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	28.0	1032.0	36.0	-0.247	0.03	1000.0	-1000.0	-0.053	-1000.0
IL2 signaling events mediated by PI3K	27.0	1601.0	58.0	-0.295	0.047	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	26.0	2192.0	84.0	-0.264	0.068	1000.0	-1000.0	-0.074	-1000.0
BCR signaling pathway	26.0	2600.0	99.0	-0.221	0.057	1000.0	-1000.0	-0.081	-1000.0
Glucocorticoid receptor regulatory network	25.0	2873.0	114.0	-0.337	0.149	1000.0	-1000.0	-0.073	-1000.0
VEGFR1 specific signals	25.0	1401.0	56.0	-0.316	0.03	1000.0	-1000.0	-0.068	-1000.0
Ceramide signaling pathway	23.0	1767.0	76.0	-0.566	0.206	1000.0	-1000.0	-0.049	-1000.0
Regulation of Telomerase	23.0	2382.0	102.0	-0.566	0.062	1000.0	-1000.0	-0.081	-1000.0
Wnt signaling	22.0	160.0	7.0	-0.044	0.028	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PTP1B	21.0	1668.0	76.0	-0.568	0.066	1000.0	-1000.0	-0.062	-1000.0
Angiopoietin receptor Tie2-mediated signaling	21.0	1905.0	88.0	-0.202	0.046	1000.0	-1000.0	-0.082	-1000.0
Visual signal transduction: Rods	21.0	1097.0	52.0	-0.157	0.04	1000.0	-1000.0	-0.062	-1000.0
FoxO family signaling	20.0	1325.0	64.0	-0.554	0.096	1000.0	-1000.0	-0.064	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	20.0	928.0	45.0	-0.369	0.078	1000.0	-1000.0	-0.071	-1000.0
Noncanonical Wnt signaling pathway	19.0	506.0	26.0	-0.099	0.029	1000.0	-1000.0	-0.057	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2339.0	120.0	-0.111	0.081	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	19.0	1539.0	78.0	-0.243	0.046	1000.0	-1000.0	-0.07	-1000.0
Syndecan-2-mediated signaling events	18.0	1302.0	69.0	-0.452	0.064	1000.0	-1000.0	-0.059	-1000.0
EPO signaling pathway	18.0	1023.0	55.0	-0.167	0.036	1000.0	-1000.0	-0.081	-1000.0
IL6-mediated signaling events	18.0	1355.0	75.0	-0.221	0.059	1000.0	-1000.0	-0.06	-1000.0
Regulation of nuclear SMAD2/3 signaling	16.0	2201.0	136.0	-0.291	0.101	1000.0	-1000.0	-0.056	-1000.0
Presenilin action in Notch and Wnt signaling	16.0	1001.0	61.0	-0.139	0.085	1000.0	-1000.0	-0.055	-1000.0
Aurora A signaling	16.0	987.0	60.0	-0.151	0.063	1000.0	-1000.0	-0.034	-1000.0
Endothelins	16.0	1548.0	96.0	-0.329	0.049	1000.0	-1000.0	-0.068	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	16.0	1189.0	74.0	-0.566	0.106	1000.0	-1000.0	-0.09	-1000.0
Thromboxane A2 receptor signaling	15.0	1624.0	105.0	-0.566	0.046	1000.0	-1000.0	-0.063	-1000.0
S1P5 pathway	15.0	257.0	17.0	-0.075	0.029	1000.0	-1000.0	-0.026	-1000.0
LPA receptor mediated events	15.0	1603.0	102.0	-0.251	0.052	1000.0	-1000.0	-0.083	-1000.0
Class I PI3K signaling events	15.0	1099.0	73.0	-0.305	0.08	1000.0	-1000.0	-0.069	-1000.0
IFN-gamma pathway	14.0	1000.0	68.0	-0.246	0.043	1000.0	-1000.0	-0.08	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1167.0	82.0	-0.029	0.03	1000.0	-1000.0	-0.09	-1000.0
Canonical Wnt signaling pathway	14.0	725.0	51.0	-0.139	0.098	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in keratinocytes	14.0	632.0	43.0	-0.217	0.042	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-alpha and p38-beta	13.0	609.0	44.0	-0.04	0.054	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	13.0	716.0	52.0	-0.114	0.045	1000.0	-1000.0	-0.05	-1000.0
S1P3 pathway	13.0	553.0	42.0	-0.244	0.052	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	0.005	0.026	1000.0	-1000.0	-0.02	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	12.0	457.0	37.0	-0.171	0.058	1000.0	-1000.0	-0.052	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1040.0	86.0	-0.148	0.053	1000.0	-1000.0	-0.095	-1000.0
Regulation of Androgen receptor activity	12.0	908.0	70.0	-0.915	0.054	1000.0	-1000.0	-0.065	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	325.0	28.0	-0.075	0.049	1000.0	-1000.0	-0.041	-1000.0
FAS signaling pathway (CD95)	11.0	555.0	47.0	-0.283	0.049	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	11.0	1402.0	125.0	-0.244	0.044	1000.0	-1000.0	-0.084	-1000.0
TCGA08_rtk_signaling	11.0	302.0	26.0	-0.224	0.057	1000.0	-1000.0	-0.018	-1000.0
ErbB4 signaling events	10.0	750.0	69.0	-0.158	0.094	1000.0	-1000.0	-0.075	-1000.0
S1P4 pathway	10.0	271.0	25.0	-0.075	0.039	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling events	10.0	54.0	5.0	0.007	0.026	1000.0	-1000.0	-0.001	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	45.0	5.0	0.011	0.029	1000.0	-1000.0	-0.013	-1000.0
ceramide signaling pathway	9.0	449.0	49.0	-0.066	0.045	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by PRL	9.0	307.0	34.0	-0.045	0.063	1000.0	-1000.0	-0.054	-1000.0
Visual signal transduction: Cones	8.0	318.0	38.0	-0.013	0.044	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	660.0	85.0	-0.039	0.082	1000.0	-1000.0	-0.063	-1000.0
mTOR signaling pathway	7.0	387.0	53.0	-0.061	0.054	1000.0	-1000.0	-0.055	-1000.0
Ephrin B reverse signaling	7.0	351.0	48.0	-0.049	0.054	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	6.0	267.0	39.0	-0.116	0.058	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	6.0	382.0	62.0	-0.04	0.065	1000.0	-1000.0	-0.082	-1000.0
Syndecan-3-mediated signaling events	6.0	235.0	35.0	-0.012	0.079	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	462.0	76.0	-0.032	0.051	1000.0	-1000.0	-0.083	-1000.0
ErbB2/ErbB3 signaling events	5.0	334.0	65.0	-0.127	0.042	1000.0	-1000.0	-0.072	-1000.0
Cellular roles of Anthrax toxin	5.0	209.0	39.0	-0.01	0.039	1000.0	-1000.0	-0.031	-1000.0
Insulin-mediated glucose transport	5.0	165.0	32.0	-0.043	0.057	1000.0	-1000.0	-0.044	-1000.0
Signaling events mediated by HDAC Class III	5.0	234.0	40.0	-0.054	0.055	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	5.0	466.0	85.0	-0.054	0.074	1000.0	-1000.0	-0.095	-1000.0
PDGFR-beta signaling pathway	5.0	503.0	97.0	-0.018	0.086	1000.0	-1000.0	-0.082	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.023	0.023	1000.0	-1000.0	-0.002	-1000.0
p38 MAPK signaling pathway	5.0	252.0	44.0	-0.065	0.057	1000.0	-1000.0	-0.052	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	101.0	17.0	-0.01	0.055	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	4.0	256.0	54.0	-0.022	0.068	1000.0	-1000.0	-0.061	-1000.0
Insulin Pathway	4.0	336.0	74.0	-0.032	0.08	1000.0	-1000.0	-0.085	-1000.0
BARD1 signaling events	3.0	220.0	57.0	-0.097	0.076	1000.0	-1000.0	-0.072	-1000.0
Osteopontin-mediated events	3.0	114.0	38.0	0.0	0.087	1000.0	-1000.0	-0.06	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	231.0	65.0	-0.007	0.103	1000.0	-1000.0	-0.056	-1000.0
Arf6 downstream pathway	3.0	165.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.034	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	226.0	68.0	-0.043	0.056	1000.0	-1000.0	-0.048	-1000.0
Nectin adhesion pathway	3.0	190.0	63.0	-0.0	0.058	1000.0	-1000.0	-0.069	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	162.0	52.0	-0.014	0.1	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	59.0	15.0	0.0	0.031	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	3.0	256.0	71.0	-0.116	0.062	1000.0	-1000.0	-0.05	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	223.0	83.0	-0.043	0.074	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class I	2.0	208.0	104.0	-0.057	0.075	1000.0	-1000.0	-0.046	-1000.0
Retinoic acid receptors-mediated signaling	2.0	118.0	58.0	-0.016	0.053	1000.0	-1000.0	-0.063	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	76.0	36.0	-0.053	0.055	1000.0	-1000.0	-0.052	-1000.0
Atypical NF-kappaB pathway	2.0	62.0	31.0	0.0	0.037	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	2.0	145.0	57.0	-0.048	0.079	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by HDAC Class II	1.0	112.0	75.0	-0.041	0.063	1000.0	-1000.0	-0.04	-1000.0
Circadian rhythm pathway	1.0	24.0	22.0	-0.014	0.069	1000.0	-1000.0	-0.044	-1000.0
Arf1 pathway	1.0	75.0	54.0	-0.0	0.049	1000.0	-1000.0	-0.026	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	-0.027	0.057	1000.0	-1000.0	-0.05	-1000.0
TRAIL signaling pathway	0.0	30.0	48.0	-0.0	0.073	1000.0	-1000.0	-0.059	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.071	1000.0	-1000.0	-0.055	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.007	0.037	1000.0	-1000.0	-0.014	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.0	0.062	1000.0	-1000.0	-0.01	-1000.0
Total	3640	201778	7203	-29.7490657508	-991.509275609	131000	-131000	-7.42068238094	-131000