Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	14.0	1106.0	76.0	-0.425	0.056	1000.0	-1000.0	-0.025	-1000.0
Endothelins	12.0	1165.0	96.0	-0.247	0.044	1000.0	-1000.0	-0.036	-1000.0
VEGFR1 specific signals	10.0	562.0	56.0	-0.133	0.044	1000.0	-1000.0	-0.029	-1000.0
IL4-mediated signaling events	9.0	887.0	91.0	-0.596	0.428	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	9.0	413.0	43.0	-0.28	0.131	1000.0	-1000.0	-0.032	-1000.0
Glypican 2 network	9.0	36.0	4.0	-0.015	-0.0	1000.0	-1000.0	-0.0	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	686.0	74.0	-0.126	0.063	1000.0	-1000.0	-0.053	-1000.0
Syndecan-1-mediated signaling events	8.0	290.0	34.0	-0.099	0.044	1000.0	-1000.0	-0.026	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	392.0	46.0	-0.419	0.052	1000.0	-1000.0	-0.061	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	807.0	97.0	-0.197	0.044	1000.0	-1000.0	-0.054	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	817.0	93.0	-0.134	0.101	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	8.0	1050.0	125.0	-0.134	0.054	1000.0	-1000.0	-0.037	-1000.0
EGFR-dependent Endothelin signaling events	8.0	188.0	21.0	-0.126	0.059	1000.0	-1000.0	-0.039	-1000.0
IL23-mediated signaling events	8.0	526.0	60.0	-0.509	0.043	1000.0	-1000.0	-0.065	-1000.0
IL12-mediated signaling events	7.0	617.0	87.0	-0.342	0.048	1000.0	-1000.0	-0.037	-1000.0
PLK2 and PLK4 events	7.0	21.0	3.0	-0.024	0.039	1000.0	-1000.0	-0.002	-1000.0
Thromboxane A2 receptor signaling	7.0	744.0	105.0	-0.126	0.049	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	7.0	468.0	62.0	-0.171	0.083	1000.0	-1000.0	-0.01	-1000.0
amb2 Integrin signaling	7.0	594.0	82.0	-0.104	0.044	1000.0	-1000.0	-0.027	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	7.0	507.0	68.0	-0.351	0.176	1000.0	-1000.0	-0.057	-1000.0
Glypican 1 network	6.0	322.0	48.0	-0.052	0.045	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	6.0	565.0	84.0	-0.127	0.083	1000.0	-1000.0	-0.03	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	281.0	45.0	-0.107	0.088	1000.0	-1000.0	-0.038	-1000.0
Nongenotropic Androgen signaling	6.0	313.0	52.0	-0.131	0.069	1000.0	-1000.0	-0.02	-1000.0
IL6-mediated signaling events	6.0	461.0	75.0	-0.245	0.052	1000.0	-1000.0	-0.061	-1000.0
TCGA08_retinoblastoma	6.0	48.0	8.0	-0.017	0.018	1000.0	-1000.0	-0.004	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	528.0	88.0	-0.174	0.045	1000.0	-1000.0	-0.062	-1000.0
Visual signal transduction: Rods	6.0	318.0	52.0	-0.221	0.085	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling events	6.0	30.0	5.0	-0.022	0.033	1000.0	-1000.0	0.024	-1000.0
LPA4-mediated signaling events	5.0	63.0	12.0	-0.045	0.013	1000.0	-1000.0	-0.012	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	179.0	34.0	-0.032	0.05	1000.0	-1000.0	-0.031	-1000.0
Osteopontin-mediated events	5.0	219.0	38.0	-0.118	0.048	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by the Hedgehog family	5.0	267.0	52.0	-0.208	0.047	1000.0	-1000.0	-0.026	-1000.0
Ephrin A  reverse signaling	5.0	39.0	7.0	-0.0	0.039	1000.0	-1000.0	-0.0	-1000.0
BMP receptor signaling	5.0	452.0	81.0	-0.108	0.077	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	5.0	365.0	68.0	-0.108	0.059	1000.0	-1000.0	-0.05	-1000.0
Nectin adhesion pathway	5.0	325.0	63.0	-0.06	0.063	1000.0	-1000.0	-0.044	-1000.0
ceramide signaling pathway	5.0	289.0	49.0	-0.077	0.055	1000.0	-1000.0	-0.039	-1000.0
Syndecan-3-mediated signaling events	5.0	203.0	35.0	-0.124	0.084	1000.0	-1000.0	-0.018	-1000.0
Calcium signaling in the CD4+ TCR pathway	5.0	183.0	31.0	-0.202	0.046	1000.0	-1000.0	-0.035	-1000.0
IL27-mediated signaling events	5.0	277.0	51.0	-0.198	0.098	1000.0	-1000.0	-0.052	-1000.0
Caspase cascade in apoptosis	4.0	313.0	74.0	-0.076	0.057	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	78.0	17.0	-0.018	0.044	1000.0	-1000.0	-0.016	-1000.0
Cellular roles of Anthrax toxin	4.0	169.0	39.0	-0.053	0.041	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	4.0	346.0	76.0	-0.127	0.048	1000.0	-1000.0	-0.059	-1000.0
p75(NTR)-mediated signaling	4.0	580.0	125.0	-0.143	0.097	1000.0	-1000.0	-0.039	-1000.0
PDGFR-alpha signaling pathway	4.0	185.0	44.0	-0.159	0.068	1000.0	-1000.0	-0.026	-1000.0
Ceramide signaling pathway	4.0	340.0	76.0	-0.126	0.085	1000.0	-1000.0	-0.033	-1000.0
TRAIL signaling pathway	4.0	234.0	48.0	-0.024	0.071	1000.0	-1000.0	-0.027	-1000.0
IL1-mediated signaling events	4.0	256.0	62.0	-0.096	0.072	1000.0	-1000.0	-0.023	-1000.0
S1P1 pathway	4.0	150.0	36.0	-0.06	0.043	1000.0	-1000.0	-0.019	-1000.0
FAS signaling pathway (CD95)	4.0	206.0	47.0	-0.134	0.058	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by PI3K	4.0	243.0	58.0	-0.074	0.048	1000.0	-1000.0	-0.048	-1000.0
EPHB forward signaling	4.0	378.0	85.0	-0.035	0.055	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	313.0	76.0	-0.088	0.066	1000.0	-1000.0	-0.052	-1000.0
Regulation of Telomerase	4.0	437.0	102.0	-0.237	0.077	1000.0	-1000.0	-0.033	-1000.0
BCR signaling pathway	4.0	414.0	99.0	-0.067	0.095	1000.0	-1000.0	-0.067	-1000.0
IGF1 pathway	4.0	276.0	57.0	-0.093	0.074	1000.0	-1000.0	-0.032	-1000.0
Plasma membrane estrogen receptor signaling	4.0	377.0	86.0	-0.085	0.078	1000.0	-1000.0	-0.053	-1000.0
E-cadherin signaling in keratinocytes	4.0	195.0	43.0	-0.052	0.044	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	357.0	78.0	-0.091	0.047	1000.0	-1000.0	-0.056	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	83.0	17.0	-0.038	0.064	1000.0	-1000.0	-0.01	-1000.0
ErbB2/ErbB3 signaling events	3.0	228.0	65.0	-0.114	0.059	1000.0	-1000.0	-0.07	-1000.0
Coregulation of Androgen receptor activity	3.0	285.0	76.0	-0.151	0.077	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Cones	3.0	148.0	38.0	-0.027	0.065	1000.0	-1000.0	-0.0	-1000.0
Syndecan-2-mediated signaling events	3.0	218.0	69.0	-0.071	0.067	1000.0	-1000.0	-0.028	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	19.0	5.0	-0.006	0.043	1000.0	-1000.0	0.02	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	230.0	61.0	-0.311	0.083	1000.0	-1000.0	-0.041	-1000.0
EPO signaling pathway	3.0	166.0	55.0	-0.057	0.043	1000.0	-1000.0	-0.028	-1000.0
mTOR signaling pathway	3.0	175.0	53.0	-0.118	0.044	1000.0	-1000.0	-0.028	-1000.0
Glucocorticoid receptor regulatory network	3.0	366.0	114.0	-0.22	0.08	1000.0	-1000.0	-0.044	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	133.0	37.0	-0.058	0.069	1000.0	-1000.0	-0.018	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	252.0	82.0	-0.068	0.044	1000.0	-1000.0	-0.045	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	184.0	52.0	-0.057	0.107	1000.0	-1000.0	-0.033	-1000.0
Ephrin B reverse signaling	3.0	181.0	48.0	-0.028	0.043	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	3.0	210.0	64.0	-0.267	0.066	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	56.0	15.0	-0.073	0.044	1000.0	-1000.0	-0.02	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	166.0	44.0	-0.039	0.04	1000.0	-1000.0	-0.01	-1000.0
Canonical Wnt signaling pathway	3.0	195.0	51.0	-0.373	0.107	1000.0	-1000.0	-0.036	-1000.0
Wnt signaling	3.0	27.0	7.0	-0.012	0.042	1000.0	-1000.0	-0.007	-1000.0
LPA receptor mediated events	3.0	403.0	102.0	-0.11	0.057	1000.0	-1000.0	-0.071	-1000.0
IL2 signaling events mediated by STAT5	3.0	77.0	22.0	-0.049	0.045	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	3.0	254.0	67.0	-0.093	0.045	1000.0	-1000.0	-0.039	-1000.0
Insulin Pathway	3.0	287.0	74.0	-0.061	0.085	1000.0	-1000.0	-0.025	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	406.0	120.0	-0.125	0.113	1000.0	-1000.0	-0.043	-1000.0
FOXM1 transcription factor network	3.0	199.0	51.0	-0.069	0.105	1000.0	-1000.0	-0.07	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	368.0	136.0	-0.15	0.147	1000.0	-1000.0	-0.042	-1000.0
Canonical NF-kappaB pathway	2.0	82.0	39.0	-0.054	0.072	1000.0	-1000.0	-0.017	-1000.0
ErbB4 signaling events	2.0	206.0	69.0	-0.044	0.054	1000.0	-1000.0	-0.032	-1000.0
Noncanonical Wnt signaling pathway	2.0	66.0	26.0	-0.03	0.042	1000.0	-1000.0	-0.031	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	247.0	85.0	-0.175	0.066	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	166.0	65.0	-0.009	0.087	1000.0	-1000.0	-0.032	-1000.0
Arf6 downstream pathway	2.0	110.0	43.0	-0.055	0.056	1000.0	-1000.0	-0.04	-1000.0
PLK1 signaling events	2.0	253.0	85.0	-0.096	0.055	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class III	2.0	97.0	40.0	-0.075	0.076	1000.0	-1000.0	-0.04	-1000.0
Reelin signaling pathway	2.0	167.0	56.0	-0.02	0.091	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	2.0	15.0	7.0	-0.008	0.033	1000.0	-1000.0	-0.013	-1000.0
Retinoic acid receptors-mediated signaling	2.0	154.0	58.0	-0.112	0.069	1000.0	-1000.0	-0.045	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	75.0	36.0	-0.062	0.073	1000.0	-1000.0	-0.025	-1000.0
Atypical NF-kappaB pathway	2.0	68.0	31.0	-0.015	0.049	1000.0	-1000.0	-0.009	-1000.0
Regulation of p38-alpha and p38-beta	2.0	137.0	54.0	-0.066	0.094	1000.0	-1000.0	-0.043	-1000.0
TCGA08_rtk_signaling	2.0	59.0	26.0	-0.052	0.075	1000.0	-1000.0	-0.018	-1000.0
Class I PI3K signaling events	2.0	195.0	73.0	-0.05	0.067	1000.0	-1000.0	-0.025	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	90.0	33.0	-0.086	0.085	1000.0	-1000.0	-0.037	-1000.0
PDGFR-beta signaling pathway	2.0	233.0	97.0	-0.054	0.09	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by PRL	2.0	82.0	34.0	-0.071	0.059	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.034	0.034	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	2.0	29.0	13.0	-0.0	0.056	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	2.0	160.0	70.0	-0.137	0.061	1000.0	-1000.0	-0.031	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	29.0	23.0	-0.033	0.075	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class II	1.0	86.0	75.0	-0.054	0.068	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	1.0	79.0	57.0	-0.078	0.098	1000.0	-1000.0	-0.045	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	48.0	28.0	-0.009	0.049	1000.0	-1000.0	-0.013	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	96.0	54.0	-0.046	0.061	1000.0	-1000.0	-0.03	-1000.0
Insulin-mediated glucose transport	1.0	51.0	32.0	-0.0	0.071	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	116.0	68.0	-0.037	0.078	1000.0	-1000.0	-0.023	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	116.0	83.0	-0.011	0.081	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class I	1.0	139.0	104.0	-0.075	0.096	1000.0	-1000.0	-0.033	-1000.0
Effects of Botulinum toxin	1.0	40.0	26.0	-0.027	0.069	1000.0	-1000.0	-0.001	-1000.0
Arf6 trafficking events	1.0	102.0	71.0	-0.045	0.066	1000.0	-1000.0	-0.028	-1000.0
S1P3 pathway	1.0	81.0	42.0	-0.045	0.049	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	1.0	86.0	44.0	-0.011	0.071	1000.0	-1000.0	-0.02	-1000.0
Aurora B signaling	1.0	117.0	67.0	-0.029	0.084	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	15.0	22.0	-0.014	0.079	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	0.0	51.0	60.0	-0.054	0.092	1000.0	-1000.0	-0.013	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.07	1000.0	-1000.0	-0.009	-1000.0
S1P5 pathway	0.0	6.0	17.0	-0.035	0.043	1000.0	-1000.0	-0.007	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	6.0	27.0	-0.0	0.094	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.005	0.051	1000.0	-1000.0	-0.0	-1000.0
S1P4 pathway	0.0	19.0	25.0	-0.0	0.049	1000.0	-1000.0	-0.012	-1000.0
Arf1 pathway	0.0	39.0	54.0	-0.002	0.085	1000.0	-1000.0	-0.012	-1000.0
Total	500	32806	7203	-13.4283668398	8.8760874834	131000	-131000	-3.92782538047	-131000