Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.007 0.158 -9999.0 0.0 -0.595 2.0 2.0 IHH -0.08 0.273 -9999.0 0.0 -0.829 23.0 23.0 SHH Np/Cholesterol/GAS1 -0.009 0.12 -9999.0 0.0 -0.497 11.0 11.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.009 0.119 0.494 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.012 0.178 -9999.0 0.0 -0.477 24.0 24.0 SMO -0.018 0.187 -9999.0 0.0 -0.507 24.0 24.0 AKT1 0.015 0.085 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.021 -9999.0 0.0 -0.284 1.0 1.0 BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.184 -9999.0 0.0 -0.499 24.0 24.0 STIL -0.008 0.147 -9999.0 0.0 -0.442 9.0 9.0 DHH N/PTCH2 -0.014 0.134 -9999.0 0.0 -0.623 9.0 9.0 DHH N/PTCH1 -0.038 0.187 -9999.0 0.0 -0.462 31.0 31.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.026 0.171 -9999.0 0.0 -0.811 9.0 9.0 PTHLH -0.016 0.186 -9999.0 0.0 -0.762 2.0 2.0 determination of left/right symmetry -0.018 0.184 -9999.0 0.0 -0.499 24.0 24.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.016 0.184 -9999.0 0.0 -0.755 2.0 2.0 IHH N/Hhip -0.079 0.226 -9999.0 0.0 -0.587 32.0 32.0 DHH N/Hhip -0.043 0.198 -9999.0 0.0 -0.686 16.0 16.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.184 -9999.0 0.0 -0.499 24.0 24.0 pancreas development -0.031 0.174 -9999.0 0.0 -0.678 12.0 12.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.021 0.162 -9999.0 0.0 -0.811 8.0 8.0 somite specification -0.018 0.184 -9999.0 0.0 -0.499 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.013 0.15 -9999.0 0.0 -0.462 7.0 7.0 SHH Np/Cholesterol/PTCH2 0.01 0.068 -9999.0 0.0 -0.497 3.0 3.0 SHH Np/Cholesterol/Megalin -0.046 0.181 -9999.0 0.0 -0.522 24.0 24.0 SHH 0.007 0.083 -9999.0 0.0 -0.624 3.0 3.0 catabolic process -0.021 0.171 -9999.0 0.0 -0.485 23.0 23.0 SMO/Vitamin D3 -0.015 0.169 -9999.0 0.0 -0.556 5.0 5.0 SHH Np/Cholesterol/Hhip -0.016 0.126 -9999.0 0.0 -0.498 12.0 12.0 LRP2 -0.079 0.259 -9999.0 0.0 -0.811 22.0 22.0 receptor-mediated endocytosis -0.09 0.199 -9999.0 0.0 -0.672 14.0 14.0 SHH Np/Cholesterol/BOC 0.012 0.066 -9999.0 0.0 -0.497 3.0 3.0 SHH Np/Cholesterol/CDO 0.009 0.069 -9999.0 0.0 -0.497 3.0 3.0 mesenchymal cell differentiation 0.016 0.125 0.494 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 -0.011 0.153 -9999.0 0.0 -0.464 7.0 7.0 IHH N/PTCH2 -0.046 0.183 -9999.0 0.0 -0.546 23.0 23.0 CDON 0.006 0.042 -9999.0 0.0 -0.284 4.0 4.0 IHH N/PTCH1 -0.021 0.173 -9999.0 0.0 -0.491 23.0 23.0 Megalin/LRPAP1 -0.053 0.201 -9999.0 0.0 -0.623 22.0 22.0 PTCH2 0.009 0.03 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.064 -9999.0 0.0 -0.504 3.0 3.0 PTCH1 -0.021 0.171 -9999.0 0.0 -0.486 23.0 23.0 HHIP -0.031 0.174 -9999.0 0.0 -0.68 12.0 12.0