Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.0 0.098 -9999.0 0.0 -0.33 16.0 16.0 epithelial cell differentiation -0.037 0.125 -9999.0 0.0 -0.46 16.0 16.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.033 0.089 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.011 0.021 -9999.0 0.0 -0.284 1.0 1.0 MYO6 -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.092 0.212 -9999.0 0.0 -0.63 21.0 21.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.003 0.127 -9999.0 0.0 -0.43 16.0 16.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.187 -9999.0 0.0 -0.477 29.0 29.0 EGF -0.728 0.248 -9999.0 0.0 -0.811 178.0 178.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.22 0.305 -9999.0 0.0 -0.634 65.0 65.0 cortical microtubule organization -0.037 0.125 -9999.0 0.0 -0.46 16.0 16.0 GO:0000145 -0.003 0.121 -9999.0 0.0 -0.41 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.038 0.127 -9999.0 0.0 -0.466 16.0 16.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.029 0.098 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.03 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.122 -9999.0 0.0 -0.402 16.0 16.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 ARF6/GTP -0.001 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.054 0.224 -9999.0 0.0 -0.811 16.0 16.0 EGFR/EGFR/EGF/EGF -0.415 0.171 -9999.0 0.0 -0.457 180.0 180.0 RhoA/GDP -0.035 0.118 -9999.0 0.0 -0.432 16.0 16.0 actin cytoskeleton organization 0.003 0.123 -9999.0 0.0 -0.412 16.0 16.0 IGF-1R heterotetramer 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.009 0.129 -9999.0 0.0 -0.811 5.0 5.0 DIAPH1 -0.002 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.037 0.125 0.46 16.0 -9999.0 0.0 16.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.03 0.1 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.003 0.126 -9999.0 0.0 -0.423 16.0 16.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.004 0.123 -9999.0 0.0 -0.411 16.0 16.0 Ephrin A1/EPHA2 -0.034 0.114 -9999.0 0.0 -0.418 16.0 16.0 SEC6/SEC8 -0.031 0.105 -9999.0 0.0 -0.384 16.0 16.0 MGAT3 -0.041 0.191 -9999.0 0.0 -0.486 29.0 29.0 HGF/MET -0.063 0.149 -9999.0 0.0 -0.448 24.0 24.0 HGF -0.025 0.172 -9999.0 0.0 -0.811 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.098 -9999.0 0.0 -0.333 16.0 16.0 actin cable formation 0.049 0.086 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.002 0.127 -9999.0 0.0 -0.411 17.0 17.0 KIFC3 -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.037 0.125 -9999.0 0.0 -0.46 16.0 16.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 PIP5K1C -0.003 0.129 -9999.0 0.0 -0.437 16.0 16.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.026 0.103 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.019 0.12 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.045 0.129 -9999.0 0.0 -0.42 21.0 21.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.021 0.093 -9999.0 0.0 -0.284 22.0 22.0 PLEKHA7 -0.006 0.132 -9999.0 0.0 -0.438 17.0 17.0 mol:GTP -0.001 0.008 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.023 0.115 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.0 0.098 -9999.0 0.0 -0.33 16.0 16.0 regulation of cell-cell adhesion 0.003 0.123 -9999.0 0.0 -0.412 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.098 -9999.0 0.0 -0.333 16.0 16.0