Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	94.0	3196.0	34.0	-0.619	0.012	1000.0	-1000.0	-0.061	-1000.0
EGFR-dependent Endothelin signaling events	77.0	1622.0	21.0	-0.728	0.018	1000.0	-1000.0	-0.072	-1000.0
Angiopoietin receptor Tie2-mediated signaling	63.0	5558.0	88.0	-0.923	0.077	1000.0	-1000.0	-0.098	-1000.0
FOXA2 and FOXA3 transcription factor networks	53.0	2463.0	46.0	-1.249	0.018	1000.0	-1000.0	-0.095	-1000.0
Glypican 2 network	48.0	192.0	4.0	-0.112	-0.107	1000.0	-1000.0	-0.015	-1000.0
PDGFR-alpha signaling pathway	38.0	1701.0	44.0	-0.305	0.026	1000.0	-1000.0	-0.067	-1000.0
Thromboxane A2 receptor signaling	33.0	3471.0	105.0	-0.728	0.079	1000.0	-1000.0	-0.065	-1000.0
Glypican 1 network	29.0	1398.0	48.0	-0.432	0.031	1000.0	-1000.0	-0.043	-1000.0
Arf6 signaling events	27.0	1732.0	62.0	-0.728	0.019	1000.0	-1000.0	-0.059	-1000.0
Signaling mediated by p38-alpha and p38-beta	24.0	1077.0	44.0	-0.168	0.012	1000.0	-1000.0	-0.053	-1000.0
BMP receptor signaling	23.0	1870.0	81.0	-0.506	0.018	1000.0	-1000.0	-0.094	-1000.0
TCGA08_retinoblastoma	23.0	187.0	8.0	-0.227	0.06	1000.0	-1000.0	-0.02	-1000.0
amb2 Integrin signaling	22.0	1820.0	82.0	-0.492	0.012	1000.0	-1000.0	-0.095	-1000.0
TCGA08_p53	22.0	159.0	7.0	-0.152	0.094	1000.0	-1000.0	-0.013	-1000.0
Endothelins	21.0	2083.0	96.0	-0.61	0.012	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	20.0	2573.0	125.0	-0.159	0.018	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	20.0	1617.0	78.0	-0.299	0.044	1000.0	-1000.0	-0.065	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1333.0	68.0	-0.599	0.085	1000.0	-1000.0	-0.122	-1000.0
Integrins in angiogenesis	18.0	1577.0	84.0	-0.543	0.032	1000.0	-1000.0	-0.082	-1000.0
FOXM1 transcription factor network	18.0	943.0	51.0	-0.221	0.023	1000.0	-1000.0	-0.162	-1000.0
IL4-mediated signaling events	17.0	1633.0	91.0	-0.88	0.48	1000.0	-1000.0	-0.143	-1000.0
Signaling events mediated by PTP1B	16.0	1246.0	76.0	-0.733	0.096	1000.0	-1000.0	-0.076	-1000.0
S1P1 pathway	15.0	561.0	36.0	-0.165	0.012	1000.0	-1000.0	-0.058	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	1034.0	74.0	-0.728	0.049	1000.0	-1000.0	-0.081	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1679.0	120.0	-0.329	0.159	1000.0	-1000.0	-0.075	-1000.0
FoxO family signaling	12.0	796.0	64.0	-0.944	0.086	1000.0	-1000.0	-0.076	-1000.0
TCR signaling in naïve CD8+ T cells	12.0	1189.0	93.0	-0.565	0.266	1000.0	-1000.0	-0.08	-1000.0
LPA4-mediated signaling events	10.0	130.0	12.0	-0.25	0.018	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by the Hedgehog family	10.0	570.0	52.0	-0.09	0.018	1000.0	-1000.0	-0.068	-1000.0
Ephrin A  reverse signaling	10.0	71.0	7.0	-0.048	-0.0	1000.0	-1000.0	-0.029	-1000.0
Glucocorticoid receptor regulatory network	10.0	1152.0	114.0	-0.617	0.164	1000.0	-1000.0	-0.073	-1000.0
Syndecan-4-mediated signaling events	10.0	721.0	67.0	-0.458	0.076	1000.0	-1000.0	-0.09	-1000.0
Coregulation of Androgen receptor activity	9.0	733.0	76.0	-0.748	0.022	1000.0	-1000.0	-0.047	-1000.0
Syndecan-1-mediated signaling events	9.0	325.0	34.0	-0.105	0.012	1000.0	-1000.0	-0.061	-1000.0
p75(NTR)-mediated signaling	9.0	1227.0	125.0	-0.466	0.031	1000.0	-1000.0	-0.103	-1000.0
Nongenotropic Androgen signaling	9.0	473.0	52.0	-0.091	0.025	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling events	9.0	48.0	5.0	-0.054	0.012	1000.0	-1000.0	-0.035	-1000.0
Aurora B signaling	9.0	624.0	67.0	-0.289	0.012	1000.0	-1000.0	-0.071	-1000.0
HIF-1-alpha transcription factor network	8.0	636.0	76.0	-0.136	0.049	1000.0	-1000.0	-0.131	-1000.0
Calcium signaling in the CD4+ TCR pathway	8.0	252.0	31.0	-0.14	0.014	1000.0	-1000.0	-0.086	-1000.0
IL27-mediated signaling events	8.0	440.0	51.0	-1.016	0.168	1000.0	-1000.0	-0.079	-1000.0
IL6-mediated signaling events	8.0	668.0	75.0	-0.26	0.052	1000.0	-1000.0	-0.096	-1000.0
Plasma membrane estrogen receptor signaling	8.0	766.0	86.0	-0.163	0.023	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling in keratinocytes	8.0	362.0	43.0	-0.278	0.035	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	7.0	609.0	87.0	-0.185	0.025	1000.0	-1000.0	-0.123	-1000.0
ErbB4 signaling events	7.0	532.0	69.0	-0.362	0.119	1000.0	-1000.0	-0.092	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	441.0	61.0	-0.197	0.092	1000.0	-1000.0	-0.072	-1000.0
Reelin signaling pathway	7.0	439.0	56.0	-0.171	0.018	1000.0	-1000.0	-0.079	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	649.0	82.0	-0.113	0.012	1000.0	-1000.0	-0.083	-1000.0
S1P3 pathway	7.0	294.0	42.0	-0.163	0.018	1000.0	-1000.0	-0.038	-1000.0
Visual signal transduction: Rods	7.0	402.0	52.0	-0.197	0.012	1000.0	-1000.0	-0.082	-1000.0
Regulation of Androgen receptor activity	7.0	503.0	70.0	-0.848	0.027	1000.0	-1000.0	-0.061	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	886.0	136.0	-0.598	0.08	1000.0	-1000.0	-0.062	-1000.0
Noncanonical Wnt signaling pathway	6.0	173.0	26.0	-0.2	0.012	1000.0	-1000.0	-0.06	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	312.0	52.0	-0.333	0.054	1000.0	-1000.0	-0.065	-1000.0
Regulation of Telomerase	6.0	707.0	102.0	-0.728	0.042	1000.0	-1000.0	-0.102	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	200.0	33.0	-0.226	0.035	1000.0	-1000.0	-0.057	-1000.0
Caspase cascade in apoptosis	5.0	378.0	74.0	-0.419	0.039	1000.0	-1000.0	-0.043	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	140.0	28.0	-0.163	0.017	1000.0	-1000.0	-0.046	-1000.0
Syndecan-2-mediated signaling events	5.0	352.0	69.0	-0.492	0.04	1000.0	-1000.0	-0.049	-1000.0
Ceramide signaling pathway	5.0	419.0	76.0	-0.728	0.25	1000.0	-1000.0	-0.057	-1000.0
EPHB forward signaling	5.0	493.0	85.0	-0.171	0.059	1000.0	-1000.0	-0.079	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	452.0	76.0	-0.054	0.028	1000.0	-1000.0	-0.068	-1000.0
BCR signaling pathway	5.0	527.0	99.0	-0.083	0.028	1000.0	-1000.0	-0.088	-1000.0
IL23-mediated signaling events	5.0	324.0	60.0	-0.116	0.023	1000.0	-1000.0	-0.15	-1000.0
BARD1 signaling events	4.0	246.0	57.0	-0.109	0.024	1000.0	-1000.0	-0.062	-1000.0
Osteopontin-mediated events	4.0	176.0	38.0	-0.116	0.048	1000.0	-1000.0	-0.101	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	254.0	54.0	-0.218	0.025	1000.0	-1000.0	-0.092	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	73.0	17.0	-0.031	0.029	1000.0	-1000.0	-0.052	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	391.0	97.0	-0.12	0.029	1000.0	-1000.0	-0.081	-1000.0
Syndecan-3-mediated signaling events	4.0	157.0	35.0	-0.17	0.018	1000.0	-1000.0	-0.062	-1000.0
Effects of Botulinum toxin	4.0	124.0	26.0	-0.209	0.014	1000.0	-1000.0	-0.054	-1000.0
Wnt signaling	4.0	31.0	7.0	-0.034	0.012	1000.0	-1000.0	-0.035	-1000.0
PDGFR-beta signaling pathway	4.0	433.0	97.0	-0.126	0.043	1000.0	-1000.0	-0.083	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	71.0	17.0	-0.011	0.025	1000.0	-1000.0	-0.039	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	286.0	85.0	-0.117	0.039	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	3.0	256.0	68.0	-0.387	0.065	1000.0	-1000.0	-0.083	-1000.0
Nectin adhesion pathway	3.0	201.0	63.0	-0.091	0.049	1000.0	-1000.0	-0.067	-1000.0
IL1-mediated signaling events	3.0	237.0	62.0	-0.139	0.057	1000.0	-1000.0	-0.095	-1000.0
S1P5 pathway	3.0	54.0	17.0	-0.051	0.026	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	258.0	83.0	-0.273	0.047	1000.0	-1000.0	-0.067	-1000.0
Canonical Wnt signaling pathway	3.0	176.0	51.0	-0.197	0.098	1000.0	-1000.0	-0.066	-1000.0
Regulation of p38-alpha and p38-beta	3.0	201.0	54.0	-0.175	0.059	1000.0	-1000.0	-0.059	-1000.0
TCGA08_rtk_signaling	3.0	102.0	26.0	-0.25	0.03	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PRL	3.0	119.0	34.0	-0.03	0.021	1000.0	-1000.0	-0.038	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	2.0	98.0	39.0	-0.189	0.018	1000.0	-1000.0	-0.022	-1000.0
Insulin-mediated glucose transport	2.0	91.0	32.0	-0.124	0.065	1000.0	-1000.0	-0.061	-1000.0
Ephrin B reverse signaling	2.0	136.0	48.0	-0.069	0.034	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	2.0	112.0	47.0	-0.099	0.022	1000.0	-1000.0	-0.041	-1000.0
IL2 signaling events mediated by PI3K	2.0	173.0	58.0	-0.056	0.056	1000.0	-1000.0	-0.089	-1000.0
LPA receptor mediated events	2.0	226.0	102.0	-0.117	0.053	1000.0	-1000.0	-0.084	-1000.0
IL2 signaling events mediated by STAT5	2.0	63.0	22.0	-0.047	0.043	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events	2.0	182.0	73.0	-0.046	0.039	1000.0	-1000.0	-0.064	-1000.0
Arf6 trafficking events	2.0	195.0	71.0	-0.348	0.04	1000.0	-1000.0	-0.068	-1000.0
IGF1 pathway	2.0	156.0	57.0	-0.036	0.04	1000.0	-1000.0	-0.089	-1000.0
S1P4 pathway	2.0	52.0	25.0	-0.051	0.026	1000.0	-1000.0	-0.052	-1000.0
ErbB2/ErbB3 signaling events	1.0	118.0	65.0	-0.117	0.032	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class II	1.0	119.0	75.0	-0.138	0.036	1000.0	-1000.0	-0.056	-1000.0
Visual signal transduction: Cones	1.0	45.0	38.0	-0.015	0.013	1000.0	-1000.0	-0.063	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	76.0	65.0	-0.05	0.062	1000.0	-1000.0	-0.055	-1000.0
Aurora A signaling	1.0	117.0	60.0	-0.112	0.038	1000.0	-1000.0	-0.046	-1000.0
PLK1 signaling events	1.0	164.0	85.0	-0.091	0.023	1000.0	-1000.0	-0.043	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	93.0	68.0	-0.124	0.046	1000.0	-1000.0	-0.056	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	50.0	37.0	-0.033	0.035	1000.0	-1000.0	-0.048	-1000.0
HIF-2-alpha transcription factor network	1.0	81.0	43.0	-0.211	0.124	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by HDAC Class I	1.0	110.0	104.0	-0.138	0.052	1000.0	-1000.0	-0.066	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	23.0	15.0	-0.0	0.024	1000.0	-1000.0	-0.03	-1000.0
Retinoic acid receptors-mediated signaling	1.0	112.0	58.0	-0.06	0.032	1000.0	-1000.0	-0.07	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	45.0	45.0	-0.023	0.058	1000.0	-1000.0	-0.082	-1000.0
Insulin Pathway	1.0	121.0	74.0	-0.038	0.033	1000.0	-1000.0	-0.086	-1000.0
VEGFR1 specific signals	1.0	90.0	56.0	-0.01	0.044	1000.0	-1000.0	-0.065	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.0	0.043	1000.0	-1000.0	-0.06	-1000.0
Canonical NF-kappaB pathway	0.0	27.0	39.0	-0.013	0.075	1000.0	-1000.0	-0.081	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.006	0.009	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.042	1000.0	-1000.0	-0.049	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.012	0.018	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	0.0	3.0	43.0	-0.022	0.023	1000.0	-1000.0	-0.039	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.126	0.012	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	0.0	46.0	55.0	-0.039	0.073	1000.0	-1000.0	-0.091	-1000.0
mTOR signaling pathway	0.0	30.0	53.0	-0.006	0.028	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by HDAC Class III	0.0	13.0	40.0	-0.019	0.021	1000.0	-1000.0	-0.042	-1000.0
TRAIL signaling pathway	0.0	41.0	48.0	-0.013	0.043	1000.0	-1000.0	-0.066	-1000.0
ceramide signaling pathway	0.0	32.0	49.0	-0.013	0.045	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	19.0	36.0	-0.016	0.037	1000.0	-1000.0	-0.063	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.0	0.044	1000.0	-1000.0	-0.039	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.002	0.031	1000.0	-1000.0	-0.052	-1000.0
Rapid glucocorticoid signaling	0.0	6.0	20.0	-0.001	0.012	1000.0	-1000.0	-0.044	-1000.0
p38 MAPK signaling pathway	0.0	42.0	44.0	-0.036	0.039	1000.0	-1000.0	-0.064	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.006	0.03	1000.0	-1000.0	-0.046	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.018	1000.0	-1000.0	-0.065	-1000.0
Total	1178	70141	7203	-31.4218136491	-994.015040354	131000	-131000	-8.65006829929	-131000