E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.022 0.149 -9999.0 0.0 -0.522 15.0 15.0 KLHL20 0.019 0.084 0.22 2.0 -0.249 1.0 3.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.0 0.114 0.337 4.0 -0.332 13.0 17.0 ENAH -0.023 0.149 -9999.0 0.0 -0.519 15.0 15.0 AP1M1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.004 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.039 -9999.0 0.0 -0.17 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.121 -9999.0 0.0 -0.397 14.0 14.0 RAPGEF1 -0.017 0.133 0.252 1.0 -0.453 14.0 15.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.155 -9999.0 0.0 -0.534 15.0 15.0 CRK -0.024 0.137 -9999.0 0.0 -0.481 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.012 0.126 -9999.0 0.0 -0.418 15.0 15.0 alphaE/beta7 Integrin 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.023 0.15 -9999.0 0.0 -0.522 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.009 0.054 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.043 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.008 0.071 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.004 0.139 -9999.0 0.0 -0.482 15.0 15.0 TIAM1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.024 0.117 -9999.0 0.0 -0.376 15.0 15.0 AKT1 -0.001 0.046 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.027 0.181 -9999.0 0.0 -0.658 15.0 15.0 RhoA/GDP 0.01 0.121 0.359 5.0 -0.331 14.0 19.0 actin cytoskeleton organization 0.021 0.068 0.18 5.0 -0.18 1.0 6.0 CDC42/GDP 0.018 0.137 0.424 8.0 -0.33 14.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.005 0.082 -9999.0 0.0 -0.287 15.0 15.0 ITGB7 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.027 0.124 -9999.0 0.0 -0.397 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.011 0.112 -9999.0 0.0 -0.374 15.0 15.0 mol:GDP 0.001 0.151 0.441 8.0 -0.385 14.0 22.0 CDC42/GTP/IQGAP1 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.009 0.113 0.25 2.0 -0.34 14.0 16.0 RAC1/GTP/IQGAP1 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.026 0.068 0.247 8.0 -9999.0 0.0 8.0 NME1 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.15 -9999.0 0.0 -0.521 15.0 15.0 regulation of cell-cell adhesion -0.001 0.067 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.011 0.032 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.007 0.092 -9999.0 0.0 -0.303 13.0 13.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.035 0.118 -9999.0 0.0 -0.378 14.0 14.0 CCND1 0.023 0.058 0.173 5.0 -9999.0 0.0 5.0 VAV2 -0.03 0.193 -9999.0 0.0 -0.515 24.0 24.0 RAP1/GDP 0.012 0.102 0.262 2.0 -0.31 14.0 16.0 adherens junction assembly -0.022 0.145 -9999.0 0.0 -0.502 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.023 0.111 -9999.0 0.0 -0.365 14.0 14.0 E-cadherin/beta catenin -0.022 0.116 -9999.0 0.0 -0.426 15.0 15.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.023 0.15 -9999.0 0.0 -0.521 15.0 15.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.021 0.097 -9999.0 0.0 -0.325 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.012 0.129 -9999.0 0.0 -0.431 15.0 15.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.019 0.159 -9999.0 0.0 -0.548 15.0 15.0