Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.393 0.289 0.572 135.0 -9999.0 0.0 135.0 KIRREL -0.114 0.198 -9999.0 0.0 -0.697 19.0 19.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.393 0.289 -9999.0 0.0 -0.573 135.0 135.0 PLCG1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.413 0.313 -9999.0 0.0 -0.564 148.0 148.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.343 0.261 -9999.0 0.0 -0.486 134.0 134.0 FYN -0.404 0.278 0.265 1.0 -0.534 148.0 149.0 mol:Ca2+ -0.406 0.308 -9999.0 0.0 -0.563 144.0 144.0 mol:DAG -0.408 0.311 -9999.0 0.0 -0.566 144.0 144.0 NPHS2 -0.319 0.326 -9999.0 0.0 -0.711 80.0 80.0 mol:IP3 -0.408 0.311 -9999.0 0.0 -0.566 144.0 144.0 regulation of endocytosis -0.37 0.277 -9999.0 0.0 -0.506 146.0 146.0 Nephrin/NEPH1/podocin/Cholesterol -0.418 0.307 -9999.0 0.0 -0.565 148.0 148.0 establishment of cell polarity -0.393 0.289 -9999.0 0.0 -0.572 135.0 135.0 Nephrin/NEPH1/podocin/NCK1-2 -0.385 0.3 -9999.0 0.0 -0.531 147.0 147.0 Nephrin/NEPH1/beta Arrestin2 -0.376 0.283 -9999.0 0.0 -0.515 146.0 146.0 NPHS1 -0.467 0.317 -9999.0 0.0 -0.691 130.0 130.0 Nephrin/NEPH1/podocin -0.397 0.294 -9999.0 0.0 -0.538 148.0 148.0 TJP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.411 0.313 -9999.0 0.0 -0.57 144.0 144.0 CD2AP 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.409 0.312 -9999.0 0.0 -0.567 144.0 144.0 GRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.478 0.31 0.275 1.0 -0.598 157.0 158.0 cytoskeleton organization -0.423 0.314 -9999.0 0.0 -0.598 135.0 135.0 Nephrin/NEPH1 -0.29 0.222 -9999.0 0.0 -0.426 135.0 135.0 Nephrin/NEPH1/ZO-1 -0.321 0.251 -9999.0 0.0 -0.484 131.0 131.0