Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.011 0.12 -9999.0 0.0 -0.385 2.0 2.0 IHH -0.049 0.231 -9999.0 0.0 -0.682 23.0 23.0 SHH Np/Cholesterol/GAS1 -0.001 0.085 -9999.0 0.0 -0.338 11.0 11.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.085 0.335 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.02 0.148 -9999.0 0.0 -0.491 5.0 5.0 SMO -0.028 0.147 -9999.0 0.0 -0.442 18.0 18.0 AKT1 -0.024 0.15 -9999.0 0.0 -0.626 7.0 7.0 ARRB2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.028 0.146 -9999.0 0.0 -0.436 18.0 18.0 STIL 0.009 0.131 -9999.0 0.0 -0.382 1.0 1.0 DHH N/PTCH2 0.011 0.111 -9999.0 0.0 -0.494 9.0 9.0 DHH N/PTCH1 -0.022 0.154 -9999.0 0.0 -0.37 31.0 31.0 PIK3CA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.008 0.143 -9999.0 0.0 -0.658 9.0 9.0 PTHLH -0.025 0.148 -9999.0 0.0 -0.484 2.0 2.0 determination of left/right symmetry -0.028 0.146 -9999.0 0.0 -0.436 18.0 18.0 PIK3R1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.025 0.147 -9999.0 0.0 -0.481 2.0 2.0 IHH N/Hhip -0.041 0.188 -9999.0 0.0 -0.465 32.0 32.0 DHH N/Hhip -0.012 0.163 -9999.0 0.0 -0.544 16.0 16.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.028 0.146 -9999.0 0.0 -0.436 18.0 18.0 pancreas development -0.009 0.143 -9999.0 0.0 -0.657 9.0 9.0 HHAT 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.039 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.0 0.129 -9999.0 0.0 -0.619 8.0 8.0 somite specification -0.028 0.146 -9999.0 0.0 -0.436 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.016 0.111 -9999.0 0.0 -0.322 18.0 18.0 SHH Np/Cholesterol/PTCH2 0.012 0.052 -9999.0 0.0 -0.389 3.0 3.0 SHH Np/Cholesterol/Megalin -0.033 0.143 -9999.0 0.0 -0.41 24.0 24.0 SHH 0.002 0.063 -9999.0 0.0 -0.498 3.0 3.0 catabolic process -0.018 0.137 -9999.0 0.0 -0.39 23.0 23.0 SMO/Vitamin D3 -0.02 0.13 -9999.0 0.0 -0.44 6.0 6.0 SHH Np/Cholesterol/Hhip -0.006 0.097 -9999.0 0.0 -0.38 12.0 12.0 LRP2 -0.05 0.216 -9999.0 0.0 -0.658 22.0 22.0 receptor-mediated endocytosis -0.055 0.183 -9999.0 0.0 -0.621 12.0 12.0 SHH Np/Cholesterol/BOC 0.014 0.053 -9999.0 0.0 -0.395 3.0 3.0 SHH Np/Cholesterol/CDO 0.012 0.053 -9999.0 0.0 -0.395 3.0 3.0 mesenchymal cell differentiation 0.006 0.097 0.378 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 0.016 0.138 -9999.0 0.0 -0.35 5.0 5.0 IHH N/PTCH2 -0.015 0.153 -9999.0 0.0 -0.434 23.0 23.0 CDON 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.01 0.141 -9999.0 0.0 -0.394 23.0 23.0 Megalin/LRPAP1 -0.02 0.168 -9999.0 0.0 -0.494 22.0 22.0 PTCH2 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.005 0.05 -9999.0 0.0 -0.393 3.0 3.0 PTCH1 -0.018 0.137 -9999.0 0.0 -0.391 23.0 23.0 HHIP -0.009 0.143 -9999.0 0.0 -0.658 9.0 9.0