Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.0 0.082 -9999.0 0.0 -0.285 15.0 15.0 epithelial cell differentiation 0.02 0.114 -9999.0 0.0 -0.372 15.0 15.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.006 0.121 0.502 6.0 -9999.0 0.0 6.0 EGFR 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.001 0.12 0.348 5.0 -0.359 15.0 20.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.069 0.192 -9999.0 0.0 -0.582 20.0 20.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.0 0.118 0.346 5.0 -0.354 15.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.147 0.346 4.0 -0.383 23.0 27.0 EGF -0.576 0.213 -9999.0 0.0 -0.647 176.0 176.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.157 0.264 -9999.0 0.0 -0.571 52.0 52.0 cortical microtubule organization 0.02 0.114 -9999.0 0.0 -0.372 15.0 15.0 GO:0000145 -0.018 0.112 0.335 5.0 -0.338 15.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.024 0.117 -9999.0 0.0 -0.376 15.0 15.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.035 0.079 -9999.0 0.0 -0.322 12.0 12.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.099 0.344 1.0 -0.329 15.0 16.0 PVRL2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.008 0.109 0.348 2.0 -0.359 14.0 16.0 ARF6/GTP 0.063 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.027 0.181 -9999.0 0.0 -0.658 15.0 15.0 EGFR/EGFR/EGF/EGF -0.289 0.164 -9999.0 0.0 -0.386 128.0 128.0 RhoA/GDP 0.022 0.11 -9999.0 0.0 -0.356 15.0 15.0 actin cytoskeleton organization -0.018 0.114 0.333 5.0 -0.348 15.0 20.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.108 -9999.0 0.0 -0.658 5.0 5.0 DIAPH1 0.031 0.103 -9999.0 0.0 -0.532 3.0 3.0 Wnt receptor signaling pathway -0.02 0.114 0.372 15.0 -9999.0 0.0 15.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.036 0.08 -9999.0 0.0 -0.327 12.0 12.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.116 0.335 5.0 -0.356 15.0 20.0 EFNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.024 0.104 0.342 2.0 -0.342 15.0 17.0 Ephrin A1/EPHA2 0.014 0.106 -9999.0 0.0 -0.346 15.0 15.0 SEC6/SEC8 -0.015 0.09 -9999.0 0.0 -0.336 14.0 14.0 MGAT3 -0.026 0.149 0.348 4.0 -0.39 23.0 27.0 HGF/MET -0.001 0.12 -9999.0 0.0 -0.371 17.0 17.0 HGF 0.001 0.117 -9999.0 0.0 -0.658 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.0 0.083 -9999.0 0.0 -0.287 15.0 15.0 actin cable formation 0.024 0.143 0.562 8.0 -0.288 1.0 9.0 KIAA1543 -0.019 0.116 0.337 5.0 -0.343 16.0 21.0 KIFC3 -0.015 0.1 -9999.0 0.0 -0.359 15.0 15.0 NCK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.0 0.12 0.348 5.0 -0.356 15.0 20.0 NCK1/GIT1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.02 0.114 -9999.0 0.0 -0.372 15.0 15.0 EXOC4 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.017 0.099 -9999.0 0.0 -0.359 15.0 15.0 PIP5K1C -0.001 0.12 0.348 5.0 -0.359 15.0 20.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.136 0.515 7.0 -9999.0 0.0 7.0 adherens junction assembly 0.001 0.129 0.352 11.0 -0.44 1.0 12.0 IGF-1R heterotetramer/IGF1 0.005 0.121 -9999.0 0.0 -0.35 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.017 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.002 0.123 0.348 5.0 -0.359 16.0 21.0 mol:GTP 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.003 0.114 0.331 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.0 0.082 -9999.0 0.0 -0.285 15.0 15.0 regulation of cell-cell adhesion -0.018 0.114 0.333 5.0 -0.348 15.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.0 0.083 -9999.0 0.0 -0.287 15.0 15.0