Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	90.0	3079.0	34.0	-0.478	0.027	1000.0	-1000.0	-0.034	-1000.0
FOXA2 and FOXA3 transcription factor networks	66.0	3062.0	46.0	-1.134	0.03	1000.0	-1000.0	-0.076	-1000.0
Angiopoietin receptor Tie2-mediated signaling	63.0	5567.0	88.0	-0.848	0.089	1000.0	-1000.0	-0.062	-1000.0
EGFR-dependent Endothelin signaling events	61.0	1294.0	21.0	-0.576	0.037	1000.0	-1000.0	-0.046	-1000.0
PDGFR-alpha signaling pathway	37.0	1657.0	44.0	-0.24	0.036	1000.0	-1000.0	-0.04	-1000.0
Thromboxane A2 receptor signaling	32.0	3447.0	105.0	-0.576	0.093	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	27.0	1325.0	48.0	-0.346	0.05	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-alpha and p38-beta	25.0	1130.0	44.0	-0.145	0.026	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	21.0	1781.0	81.0	-0.377	0.053	1000.0	-1000.0	-0.057	-1000.0
Endothelins	21.0	2055.0	96.0	-0.599	0.038	1000.0	-1000.0	-0.055	-1000.0
Arf6 signaling events	20.0	1274.0	62.0	-0.576	0.058	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	19.0	2440.0	125.0	-0.133	0.06	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	19.0	1550.0	78.0	-0.243	0.052	1000.0	-1000.0	-0.046	-1000.0
Integrins in angiogenesis	16.0	1423.0	84.0	-0.426	0.059	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PTP1B	15.0	1183.0	76.0	-0.579	0.082	1000.0	-1000.0	-0.039	-1000.0
IL4-mediated signaling events	15.0	1373.0	91.0	-0.823	0.432	1000.0	-1000.0	-0.116	-1000.0
amb2 Integrin signaling	15.0	1243.0	82.0	-0.399	0.036	1000.0	-1000.0	-0.042	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	15.0	1065.0	68.0	-0.474	0.078	1000.0	-1000.0	-0.085	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1816.0	120.0	-0.254	0.129	1000.0	-1000.0	-0.056	-1000.0
Ceramide signaling pathway	14.0	1091.0	76.0	-0.576	0.203	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	14.0	514.0	36.0	-0.13	0.026	1000.0	-1000.0	-0.053	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	13.0	1015.0	74.0	-0.576	0.063	1000.0	-1000.0	-0.067	-1000.0
FoxO family signaling	12.0	776.0	64.0	-0.893	0.062	1000.0	-1000.0	-0.061	-1000.0
Ephrin A  reverse signaling	10.0	70.0	7.0	-0.031	0.0	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	10.0	1173.0	114.0	-0.543	0.133	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by the Hedgehog family	9.0	517.0	52.0	-0.055	0.039	1000.0	-1000.0	-0.042	-1000.0
Plasma membrane estrogen receptor signaling	9.0	844.0	86.0	-0.118	0.047	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling events	9.0	45.0	5.0	-0.027	0.026	1000.0	-1000.0	0.0	-1000.0
LPA4-mediated signaling events	8.0	105.0	12.0	-0.154	0.007	1000.0	-1000.0	-0.027	-1000.0
TCR signaling in naïve CD8+ T cells	8.0	793.0	93.0	-0.226	0.114	1000.0	-1000.0	-0.054	-1000.0
Nongenotropic Androgen signaling	8.0	456.0	52.0	-0.112	0.049	1000.0	-1000.0	-0.047	-1000.0
IL6-mediated signaling events	8.0	610.0	75.0	-0.211	0.04	1000.0	-1000.0	-0.047	-1000.0
E-cadherin signaling in keratinocytes	8.0	356.0	43.0	-0.213	0.041	1000.0	-1000.0	-0.042	-1000.0
Caspase cascade in apoptosis	7.0	573.0	74.0	-0.424	0.065	1000.0	-1000.0	-0.044	-1000.0
Coregulation of Androgen receptor activity	7.0	544.0	76.0	-0.663	0.049	1000.0	-1000.0	-0.031	-1000.0
p75(NTR)-mediated signaling	7.0	988.0	125.0	-0.377	0.071	1000.0	-1000.0	-0.077	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	631.0	82.0	-0.062	0.028	1000.0	-1000.0	-0.064	-1000.0
S1P3 pathway	7.0	312.0	42.0	-0.113	0.037	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	861.0	136.0	-0.472	0.092	1000.0	-1000.0	-0.043	-1000.0
ErbB4 signaling events	6.0	477.0	69.0	-0.281	0.089	1000.0	-1000.0	-0.056	-1000.0
Noncanonical Wnt signaling pathway	6.0	171.0	26.0	-0.167	0.027	1000.0	-1000.0	-0.057	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	385.0	61.0	-0.141	0.079	1000.0	-1000.0	-0.048	-1000.0
Syndecan-3-mediated signaling events	6.0	225.0	35.0	-0.104	0.071	1000.0	-1000.0	-0.039	-1000.0
EPHB forward signaling	6.0	516.0	85.0	-0.12	0.073	1000.0	-1000.0	-0.074	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	202.0	31.0	-0.094	0.027	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	6.0	334.0	51.0	-0.967	0.241	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	506.0	76.0	-0.03	0.047	1000.0	-1000.0	-0.06	-1000.0
IL23-mediated signaling events	6.0	417.0	60.0	-0.066	0.046	1000.0	-1000.0	-0.076	-1000.0
PDGFR-beta signaling pathway	6.0	601.0	97.0	-0.037	0.056	1000.0	-1000.0	-0.063	-1000.0
Syndecan-1-mediated signaling events	5.0	173.0	34.0	-0.035	0.027	1000.0	-1000.0	-0.047	-1000.0
HIF-1-alpha transcription factor network	5.0	417.0	76.0	-0.09	0.101	1000.0	-1000.0	-0.068	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	492.0	85.0	-0.107	0.105	1000.0	-1000.0	-0.054	-1000.0
IFN-gamma pathway	5.0	347.0	68.0	-0.308	0.064	1000.0	-1000.0	-0.061	-1000.0
Reelin signaling pathway	5.0	334.0	56.0	-0.114	0.067	1000.0	-1000.0	-0.043	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	305.0	52.0	-0.245	0.08	1000.0	-1000.0	-0.042	-1000.0
TCGA08_p53	5.0	38.0	7.0	-0.032	0.028	1000.0	-1000.0	-0.011	-1000.0
Effects of Botulinum toxin	5.0	140.0	26.0	-0.15	0.048	1000.0	-1000.0	-0.015	-1000.0
TCGA08_rtk_signaling	5.0	146.0	26.0	-0.19	0.063	1000.0	-1000.0	-0.013	-1000.0
Regulation of Telomerase	5.0	581.0	102.0	-0.576	0.069	1000.0	-1000.0	-0.054	-1000.0
Syndecan-4-mediated signaling events	5.0	362.0	67.0	-0.367	0.099	1000.0	-1000.0	-0.046	-1000.0
Regulation of Androgen receptor activity	5.0	383.0	70.0	-0.774	0.042	1000.0	-1000.0	-0.053	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	139.0	28.0	-0.113	0.044	1000.0	-1000.0	-0.025	-1000.0
Osteopontin-mediated events	4.0	175.0	38.0	-0.07	0.055	1000.0	-1000.0	-0.049	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	231.0	54.0	-0.048	0.042	1000.0	-1000.0	-0.054	-1000.0
Cellular roles of Anthrax toxin	4.0	167.0	39.0	-0.145	0.035	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	4.0	234.0	49.0	-0.0	0.043	1000.0	-1000.0	-0.049	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	61.0	15.0	-0.009	0.027	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	4.0	235.0	54.0	-0.129	0.064	1000.0	-1000.0	-0.051	-1000.0
BCR signaling pathway	4.0	416.0	99.0	-0.05	0.058	1000.0	-1000.0	-0.058	-1000.0
Visual signal transduction: Rods	4.0	237.0	52.0	-0.145	0.051	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by PRL	4.0	157.0	34.0	-0.041	0.039	1000.0	-1000.0	-0.044	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	72.0	17.0	-0.01	0.041	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	3.0	249.0	69.0	-0.399	0.053	1000.0	-1000.0	-0.043	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	358.0	97.0	-0.07	0.049	1000.0	-1000.0	-0.064	-1000.0
PLK1 signaling events	3.0	301.0	85.0	-0.005	0.053	1000.0	-1000.0	-0.032	-1000.0
S1P5 pathway	3.0	58.0	17.0	-0.014	0.026	1000.0	-1000.0	-0.023	-1000.0
Ephrin B reverse signaling	3.0	178.0	48.0	-0.038	0.039	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	3.0	178.0	51.0	-0.141	0.07	1000.0	-1000.0	-0.049	-1000.0
Wnt signaling	3.0	27.0	7.0	-0.007	0.027	1000.0	-1000.0	-0.024	-1000.0
LPA receptor mediated events	3.0	360.0	102.0	-0.079	0.056	1000.0	-1000.0	-0.055	-1000.0
Arf6 trafficking events	3.0	270.0	71.0	-0.264	0.045	1000.0	-1000.0	-0.036	-1000.0
IGF1 pathway	3.0	173.0	57.0	-0.021	0.062	1000.0	-1000.0	-0.058	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.015	0.015	1000.0	-1000.0	-0.003	-1000.0
S1P4 pathway	3.0	82.0	25.0	-0.007	0.052	1000.0	-1000.0	-0.036	-1000.0
ErbB2/ErbB3 signaling events	2.0	176.0	65.0	-0.056	0.049	1000.0	-1000.0	-0.063	-1000.0
BARD1 signaling events	2.0	144.0	57.0	-0.045	0.056	1000.0	-1000.0	-0.05	-1000.0
EPO signaling pathway	2.0	111.0	55.0	-0.01	0.073	1000.0	-1000.0	-0.052	-1000.0
mTOR signaling pathway	2.0	116.0	53.0	-0.016	0.045	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	2.0	150.0	63.0	-0.027	0.053	1000.0	-1000.0	-0.051	-1000.0
IL1-mediated signaling events	2.0	177.0	62.0	-0.099	0.071	1000.0	-1000.0	-0.06	-1000.0
HIF-2-alpha transcription factor network	2.0	107.0	43.0	-0.17	0.091	1000.0	-1000.0	-0.051	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	233.0	83.0	-0.239	0.047	1000.0	-1000.0	-0.045	-1000.0
Class I PI3K signaling events	2.0	146.0	73.0	-0.018	0.045	1000.0	-1000.0	-0.055	-1000.0
Aurora B signaling	2.0	164.0	67.0	-0.236	0.053	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class II	1.0	97.0	75.0	-0.092	0.066	1000.0	-1000.0	-0.036	-1000.0
IL12-mediated signaling events	1.0	150.0	87.0	-0.177	0.061	1000.0	-1000.0	-0.09	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	110.0	65.0	-0.007	0.065	1000.0	-1000.0	-0.052	-1000.0
Arf6 downstream pathway	1.0	78.0	43.0	-0.042	0.043	1000.0	-1000.0	-0.031	-1000.0
Insulin-mediated glucose transport	1.0	34.0	32.0	-0.017	0.047	1000.0	-1000.0	-0.033	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	70.0	68.0	-0.019	0.054	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	1.0	91.0	47.0	-0.104	0.039	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	1.0	95.0	58.0	-0.029	0.057	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by PI3K	1.0	89.0	58.0	-0.015	0.06	1000.0	-1000.0	-0.052	-1000.0
TCGA08_retinoblastoma	1.0	8.0	8.0	-0.048	0.031	1000.0	-1000.0	-0.004	-1000.0
Insulin Pathway	1.0	120.0	74.0	-0.017	0.07	1000.0	-1000.0	-0.055	-1000.0
VEGFR1 specific signals	1.0	88.0	56.0	-0.014	0.059	1000.0	-1000.0	-0.058	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	50.0	33.0	-0.048	0.064	1000.0	-1000.0	-0.025	-1000.0
FOXM1 transcription factor network	1.0	91.0	51.0	-0.078	0.055	1000.0	-1000.0	-0.102	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	16.0	23.0	-0.013	0.046	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	0.0	7.0	39.0	-0.0	0.064	1000.0	-1000.0	-0.041	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.01	0.025	1000.0	-1000.0	-0.015	-1000.0
Visual signal transduction: Cones	0.0	24.0	38.0	-0.015	0.053	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.009	0.056	1000.0	-1000.0	-0.04	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	16.0	17.0	0.011	0.043	1000.0	-1000.0	-0.037	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.026	0.038	1000.0	-1000.0	0.002	-1000.0
Aurora A signaling	0.0	16.0	60.0	-0.011	0.06	1000.0	-1000.0	-0.028	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.015	0.042	1000.0	-1000.0	-0.018	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	4.0	37.0	-0.007	0.062	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by HDAC Class III	0.0	11.0	40.0	-0.047	0.048	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	0.0	11.0	48.0	-0.0	0.069	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class I	0.0	90.0	104.0	-0.092	0.065	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.053	0.055	1000.0	-1000.0	-0.047	-1000.0
Atypical NF-kappaB pathway	0.0	8.0	31.0	-0.0	0.039	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	36.0	45.0	0.001	0.074	1000.0	-1000.0	-0.056	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.002	0.003	1000.0	-1000.0	-0.002	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.06	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	0.0	8.0	22.0	0.008	0.04	1000.0	-1000.0	-0.046	-1000.0
Rapid glucocorticoid signaling	0.0	4.0	20.0	-0.003	0.033	1000.0	-1000.0	-0.008	-1000.0
p38 MAPK signaling pathway	0.0	29.0	44.0	-0.0	0.05	1000.0	-1000.0	-0.036	-1000.0
Arf1 pathway	0.0	16.0	54.0	-0.001	0.05	1000.0	-1000.0	-0.023	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.073	1000.0	-1000.0	0.0	-1000.0
Total	1007	64954	7203	-23.8521240805	7.75344392192	131000	-131000	-5.82306814269	-131000