Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.062 0.149 0.401 72.0 -9999.0 0.0 72.0 KIRREL -0.033 0.159 -9999.0 0.0 -0.606 33.0 33.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.063 0.149 -9999.0 0.0 -0.401 72.0 72.0 PLCG1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.045 0.108 -9999.0 0.0 -0.345 34.0 34.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.003 0.094 -9999.0 0.0 -0.459 4.0 4.0 FYN -0.023 0.109 -9999.0 0.0 -0.329 34.0 34.0 mol:Ca2+ -0.045 0.107 -9999.0 0.0 -0.342 34.0 34.0 mol:DAG -0.045 0.108 -9999.0 0.0 -0.343 34.0 34.0 NPHS2 -0.006 0.041 -9999.0 0.0 -0.547 2.0 2.0 mol:IP3 -0.045 0.108 -9999.0 0.0 -0.343 34.0 34.0 regulation of endocytosis -0.017 0.102 -9999.0 0.0 -0.371 8.0 8.0 Nephrin/NEPH1/podocin/Cholesterol -0.047 0.111 -9999.0 0.0 -0.354 34.0 34.0 establishment of cell polarity -0.062 0.149 -9999.0 0.0 -0.401 72.0 72.0 Nephrin/NEPH1/podocin/NCK1-2 -0.041 0.099 -9999.0 0.0 -0.551 4.0 4.0 Nephrin/NEPH1/beta Arrestin2 -0.013 0.104 -9999.0 0.0 -0.376 8.0 8.0 NPHS1 -0.038 0.147 -9999.0 0.0 -0.499 42.0 42.0 Nephrin/NEPH1/podocin -0.027 0.108 -9999.0 0.0 -0.33 34.0 34.0 TJP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.013 0.029 -9999.0 0.0 -0.607 1.0 1.0 NCK2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.045 0.108 -9999.0 0.0 -0.345 34.0 34.0 CD2AP 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.046 0.109 -9999.0 0.0 -0.345 34.0 34.0 GRB2 0.013 0.024 -9999.0 0.0 -0.495 1.0 1.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.041 0.131 -9999.0 0.0 -0.337 47.0 47.0 cytoskeleton organization -0.003 0.111 -9999.0 0.0 -0.461 6.0 6.0 Nephrin/NEPH1 -0.044 0.106 -9999.0 0.0 -0.284 72.0 72.0 Nephrin/NEPH1/ZO-1 -0.048 0.117 -9999.0 0.0 -0.374 33.0 33.0