Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.097 0.294 -9999.0 0.0 -0.723 56.0 56.0 IHH -0.011 0.081 -9999.0 0.0 -0.524 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.091 0.155 -9999.0 0.0 -0.324 131.0 131.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.09 0.154 0.322 131.0 -9999.0 0.0 131.0 SMO/beta Arrestin2 -0.033 0.177 -9999.0 0.0 -0.742 14.0 14.0 SMO -0.043 0.187 -9999.0 0.0 -0.727 17.0 17.0 AKT1 0.005 0.082 -9999.0 0.0 -0.32 2.0 2.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.007 0.066 -9999.0 0.0 -0.57 6.0 6.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.042 0.184 -9999.0 0.0 -0.711 17.0 17.0 STIL -0.092 0.222 -9999.0 0.0 -0.547 63.0 63.0 DHH N/PTCH2 -0.062 0.15 -9999.0 0.0 -0.412 70.0 70.0 DHH N/PTCH1 -0.068 0.198 -9999.0 0.0 -0.619 26.0 26.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.05 0.181 -9999.0 0.0 -0.557 52.0 52.0 PTHLH -0.108 0.343 -9999.0 0.0 -0.936 54.0 54.0 determination of left/right symmetry -0.042 0.184 -9999.0 0.0 -0.711 17.0 17.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.106 0.338 -9999.0 0.0 -0.921 54.0 54.0 IHH N/Hhip -0.115 0.213 -9999.0 0.0 -0.452 128.0 128.0 DHH N/Hhip -0.15 0.218 -9999.0 0.0 -0.435 160.0 160.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.042 0.184 -9999.0 0.0 -0.711 17.0 17.0 pancreas development -0.14 0.256 -9999.0 0.0 -0.558 125.0 125.0 HHAT -0.006 0.11 -9999.0 0.0 -0.586 16.0 16.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.017 0.124 -9999.0 0.0 -0.503 28.0 28.0 somite specification -0.042 0.184 -9999.0 0.0 -0.711 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.093 0.217 -9999.0 0.0 -0.563 53.0 53.0 SHH Np/Cholesterol/PTCH2 -0.088 0.152 -9999.0 0.0 -0.32 129.0 129.0 SHH Np/Cholesterol/Megalin -0.183 0.213 -9999.0 0.0 -0.367 232.0 232.0 SHH -0.082 0.194 -9999.0 0.0 -0.417 111.0 111.0 catabolic process -0.043 0.185 -9999.0 0.0 -0.631 21.0 21.0 SMO/Vitamin D3 -0.083 0.221 -9999.0 0.0 -0.601 44.0 44.0 SHH Np/Cholesterol/Hhip -0.156 0.207 -9999.0 0.0 -0.365 199.0 199.0 LRP2 -0.192 0.277 -9999.0 0.0 -0.56 166.0 166.0 receptor-mediated endocytosis -0.179 0.223 -9999.0 0.0 -0.592 75.0 75.0 SHH Np/Cholesterol/BOC -0.079 0.148 -9999.0 0.0 -0.324 114.0 114.0 SHH Np/Cholesterol/CDO -0.094 0.16 -9999.0 0.0 -0.332 132.0 132.0 mesenchymal cell differentiation 0.155 0.206 0.363 199.0 -9999.0 0.0 199.0 mol:Vitamin D3 -0.09 0.219 -9999.0 0.0 -0.567 52.0 52.0 IHH N/PTCH2 -0.011 0.11 -9999.0 0.0 -0.463 23.0 23.0 CDON -0.021 0.14 -9999.0 0.0 -0.571 28.0 28.0 IHH N/PTCH1 -0.043 0.187 -9999.0 0.0 -0.637 21.0 21.0 Megalin/LRPAP1 -0.144 0.194 -9999.0 0.0 -0.4 166.0 166.0 PTCH2 -0.011 0.12 -9999.0 0.0 -0.573 20.0 20.0 SHH Np/Cholesterol -0.077 0.145 -9999.0 0.0 -0.325 111.0 111.0 PTCH1 -0.043 0.186 -9999.0 0.0 -0.634 21.0 21.0 HHIP -0.14 0.256 -9999.0 0.0 -0.559 125.0 125.0