Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.024 0.106 -9999.0 0.0 -0.456 1.0 1.0 epithelial cell differentiation -0.063 0.115 -9999.0 0.0 -0.305 53.0 53.0 CYFIP2 0.008 0.058 -9999.0 0.0 -0.54 5.0 5.0 ENAH 0.009 0.104 -9999.0 0.0 -0.372 1.0 1.0 EGFR -0.083 0.215 -9999.0 0.0 -0.555 79.0 79.0 EPHA2 -0.019 0.127 -9999.0 0.0 -0.503 30.0 30.0 MYO6 -0.026 0.124 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.003 0.033 -9999.0 0.0 -0.317 5.0 5.0 AQP5 -0.139 0.187 -9999.0 0.0 -0.521 68.0 68.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.026 0.122 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.13 -9999.0 0.0 -0.553 2.0 2.0 EGF -0.047 0.179 -9999.0 0.0 -0.564 49.0 49.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.078 0.133 -9999.0 0.0 -0.537 19.0 19.0 cortical microtubule organization -0.063 0.115 -9999.0 0.0 -0.305 53.0 53.0 GO:0000145 -0.024 0.117 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.063 0.116 -9999.0 0.0 -0.308 53.0 53.0 MLLT4 0.013 0.029 -9999.0 0.0 -0.607 1.0 1.0 ARF6/GDP -0.058 0.097 -9999.0 0.0 -0.41 9.0 9.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.019 0.069 -9999.0 0.0 -0.413 3.0 3.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.026 0.123 -9999.0 0.0 -0.379 2.0 2.0 PVRL2 0.012 0.037 -9999.0 0.0 -0.551 2.0 2.0 ZYX -0.031 0.128 -9999.0 0.0 -0.529 1.0 1.0 ARF6/GTP -0.017 0.062 -9999.0 0.0 -0.377 3.0 3.0 CDH1 -0.118 0.241 -9999.0 0.0 -0.549 109.0 109.0 EGFR/EGFR/EGF/EGF -0.124 0.17 -9999.0 0.0 -0.532 40.0 40.0 RhoA/GDP -0.058 0.105 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.021 0.121 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.013 0.024 -9999.0 0.0 -0.494 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.024 -9999.0 0.0 -0.495 1.0 1.0 IGF1 -0.008 0.113 -9999.0 0.0 -0.57 18.0 18.0 DIAPH1 0.0 0.045 -9999.0 0.0 -0.637 2.0 2.0 Wnt receptor signaling pathway 0.063 0.115 0.305 53.0 -9999.0 0.0 53.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.058 0.098 -9999.0 0.0 -0.41 9.0 9.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.022 0.124 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.011 0.041 -9999.0 0.0 -0.495 3.0 3.0 LPP -0.04 0.135 -9999.0 0.0 -0.443 5.0 5.0 Ephrin A1/EPHA2 -0.07 0.115 -9999.0 0.0 -0.471 8.0 8.0 SEC6/SEC8 -0.05 0.094 -9999.0 0.0 -0.484 3.0 3.0 MGAT3 -0.033 0.132 -9999.0 0.0 -0.565 2.0 2.0 HGF/MET -0.162 0.178 -9999.0 0.0 -0.516 59.0 59.0 HGF -0.078 0.203 -9999.0 0.0 -0.52 80.0 80.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.024 0.107 -9999.0 0.0 -0.46 1.0 1.0 actin cable formation 0.021 0.103 -9999.0 0.0 -0.325 3.0 3.0 KIAA1543 -0.062 0.173 -9999.0 0.0 -0.56 22.0 22.0 KIFC3 -0.027 0.127 -9999.0 0.0 -0.599 1.0 1.0 NCK1 0.013 0.029 -9999.0 0.0 -0.607 1.0 1.0 EXOC3 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.043 0.136 -9999.0 0.0 -0.472 5.0 5.0 NCK1/GIT1 -0.001 0.02 -9999.0 0.0 -0.44 1.0 1.0 mol:GDP -0.063 0.115 -9999.0 0.0 -0.305 53.0 53.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.026 0.124 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.026 0.124 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.004 0.081 -9999.0 0.0 -0.607 8.0 8.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.115 -9999.0 0.0 -0.377 5.0 5.0 adherens junction assembly -0.042 0.169 -9999.0 0.0 -0.525 22.0 22.0 IGF-1R heterotetramer/IGF1 -0.065 0.116 -9999.0 0.0 -0.563 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.003 0.033 -9999.0 0.0 -0.409 3.0 3.0 MET -0.142 0.253 -9999.0 0.0 -0.546 129.0 129.0 PLEKHA7 -0.035 0.137 -9999.0 0.0 -0.571 5.0 5.0 mol:GTP -0.019 0.069 -9999.0 0.0 -0.41 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.006 0.116 -9999.0 0.0 -0.458 3.0 3.0 cortical actin cytoskeleton stabilization -0.024 0.106 -9999.0 0.0 -0.456 1.0 1.0 regulation of cell-cell adhesion -0.021 0.121 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.024 0.107 -9999.0 0.0 -0.46 1.0 1.0