E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.027 0.14 -9999.0 0.0 -0.428 47.0 47.0 KLHL20 0.011 0.071 0.159 5.0 -0.218 6.0 11.0 CYFIP2 0.023 0.033 -9999.0 0.0 -0.249 5.0 5.0 Rac1/GDP -0.003 0.094 0.261 4.0 -0.262 40.0 44.0 ENAH -0.031 0.145 -9999.0 0.0 -0.424 52.0 52.0 AP1M1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.003 0.064 -9999.0 0.0 -0.237 1.0 1.0 ABI1/Sra1/Nap1 -0.014 0.036 -9999.0 0.0 -0.156 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.02 0.118 -9999.0 0.0 -0.263 63.0 63.0 RAPGEF1 -0.018 0.133 0.245 4.0 -0.375 48.0 52.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.151 -9999.0 0.0 -0.431 54.0 54.0 CRK -0.029 0.134 0.225 1.0 -0.403 48.0 49.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.106 -9999.0 0.0 -0.269 55.0 55.0 alphaE/beta7 Integrin 0.018 0.072 -9999.0 0.0 -0.307 19.0 19.0 IQGAP1 0.022 0.033 -9999.0 0.0 -0.228 6.0 6.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.025 -9999.0 0.0 -0.235 1.0 1.0 DLG1 -0.03 0.144 -9999.0 0.0 -0.422 52.0 52.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.013 0.044 -9999.0 0.0 -0.18 1.0 1.0 MLLT4 0.024 0.022 -9999.0 0.0 -0.431 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.014 0.057 -9999.0 0.0 -0.23 1.0 1.0 ARF6 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.019 0.118 -9999.0 0.0 -0.317 55.0 55.0 TIAM1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.029 0.088 -9999.0 0.0 -0.221 48.0 48.0 AKT1 -0.003 0.042 0.141 1.0 -0.136 1.0 2.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.044 0.147 -9999.0 0.0 -0.431 52.0 52.0 RhoA/GDP 0.005 0.101 0.252 7.0 -0.262 42.0 49.0 actin cytoskeleton organization 0.015 0.061 0.163 18.0 -0.159 6.0 24.0 CDC42/GDP -0.0 0.098 0.249 4.0 -0.259 29.0 33.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.08 -9999.0 0.0 -0.228 53.0 53.0 ITGB7 -0.0 0.095 -9999.0 0.0 -0.431 19.0 19.0 RAC1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.032 0.094 -9999.0 0.0 -0.236 48.0 48.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.016 0.085 -9999.0 0.0 -0.219 52.0 52.0 mol:GDP -0.011 0.111 0.255 8.0 -0.299 44.0 52.0 CDC42/GTP/IQGAP1 0.028 0.023 -9999.0 0.0 -0.234 2.0 2.0 JUP 0.02 0.052 -9999.0 0.0 -0.388 7.0 7.0 p120 catenin/RhoA/GDP 0.009 0.103 0.257 5.0 -0.267 41.0 46.0 RAC1/GTP/IQGAP1 0.028 0.024 -9999.0 0.0 -0.258 2.0 2.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.052 0.134 19.0 -0.168 14.0 33.0 NME1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.031 0.145 -9999.0 0.0 -0.422 53.0 53.0 regulation of cell-cell adhesion -0.008 0.054 -9999.0 0.0 -0.209 1.0 1.0 WASF2 0.009 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.001 0.08 0.235 2.0 -0.263 1.0 3.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.028 0.123 -9999.0 0.0 -0.258 66.0 66.0 CCND1 0.012 0.061 0.155 15.0 -0.208 14.0 29.0 VAV2 -0.011 0.153 -9999.0 0.0 -0.62 6.0 6.0 RAP1/GDP 0.007 0.089 0.26 3.0 -0.256 4.0 7.0 adherens junction assembly -0.029 0.141 -9999.0 0.0 -0.409 53.0 53.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.015 0.115 -9999.0 0.0 -0.249 66.0 66.0 E-cadherin/beta catenin -0.028 0.104 -9999.0 0.0 -0.323 50.0 50.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.03 0.143 -9999.0 0.0 -0.423 50.0 50.0 PIK3CA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.016 0.085 -9999.0 0.0 -0.35 6.0 6.0 E-cadherin/beta catenin/alpha catenin 0.017 0.1 -9999.0 0.0 -0.259 52.0 52.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.028 0.154 -9999.0 0.0 -0.44 54.0 54.0