Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.189 -9999.0 0.0 -0.577 47.0 47.0 IHH 0.012 0.055 -9999.0 0.0 -0.188 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.01 0.085 0.154 13.0 -0.239 47.0 60.0 LRPAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.01 0.084 0.238 47.0 -0.153 13.0 60.0 SMO/beta Arrestin2 -0.005 0.112 -9999.0 0.0 -0.356 29.0 29.0 SMO -0.017 0.11 -9999.0 0.0 -0.366 31.0 31.0 AKT1 0.001 0.098 -9999.0 0.0 -0.465 13.0 13.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.038 -9999.0 0.0 -0.31 5.0 5.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.017 0.109 -9999.0 0.0 -0.361 31.0 31.0 STIL -0.009 0.132 0.188 54.0 -0.268 57.0 111.0 DHH N/PTCH2 0.003 0.088 -9999.0 0.0 -0.308 31.0 31.0 DHH N/PTCH1 -0.019 0.124 -9999.0 0.0 -0.285 72.0 72.0 PIK3CA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.01 0.11 -9999.0 0.0 -0.295 49.0 49.0 PTHLH -0.059 0.252 -9999.0 0.0 -0.77 47.0 47.0 determination of left/right symmetry -0.017 0.109 -9999.0 0.0 -0.361 31.0 31.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.058 0.249 -9999.0 0.0 -0.761 47.0 47.0 IHH N/Hhip -0.039 0.136 -9999.0 0.0 -0.34 69.0 69.0 DHH N/Hhip -0.05 0.144 -9999.0 0.0 -0.321 91.0 91.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.017 0.109 -9999.0 0.0 -0.361 31.0 31.0 pancreas development -0.058 0.16 -9999.0 0.0 -0.431 66.0 66.0 HHAT 0.012 0.076 -9999.0 0.0 -0.431 13.0 13.0 PI3K 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.015 0.045 -9999.0 0.0 -0.431 2.0 2.0 somite specification -0.017 0.109 -9999.0 0.0 -0.361 31.0 31.0 SHH Np/Cholesterol/PTCH1 -0.034 0.112 -9999.0 0.0 -0.256 83.0 83.0 SHH Np/Cholesterol/PTCH2 -0.017 0.083 0.153 1.0 -0.241 51.0 52.0 SHH Np/Cholesterol/Megalin -0.056 0.125 0.153 8.0 -0.276 97.0 105.0 SHH -0.03 0.097 -9999.0 0.0 -0.31 47.0 47.0 catabolic process -0.017 0.117 -9999.0 0.0 -0.344 46.0 46.0 SMO/Vitamin D3 -0.031 0.115 0.229 2.0 -0.309 43.0 45.0 SHH Np/Cholesterol/Hhip -0.048 0.119 0.154 6.0 -0.274 87.0 93.0 LRP2 -0.089 0.18 -9999.0 0.0 -0.302 162.0 162.0 receptor-mediated endocytosis -0.063 0.142 -9999.0 0.0 -0.375 53.0 53.0 SHH Np/Cholesterol/BOC -0.014 0.081 -9999.0 0.0 -0.239 49.0 49.0 SHH Np/Cholesterol/CDO -0.019 0.088 -9999.0 0.0 -0.25 52.0 52.0 mesenchymal cell differentiation 0.047 0.119 0.272 87.0 -0.152 6.0 93.0 mol:Vitamin D3 0.0 0.144 0.2 58.0 -0.256 83.0 141.0 IHH N/PTCH2 0.023 0.053 -9999.0 0.0 -0.373 5.0 5.0 CDON 0.003 0.092 -9999.0 0.0 -0.431 19.0 19.0 IHH N/PTCH1 -0.01 0.121 -9999.0 0.0 -0.346 46.0 46.0 Megalin/LRPAP1 -0.05 0.136 -9999.0 0.0 -0.306 93.0 93.0 PTCH2 0.015 0.05 -9999.0 0.0 -0.431 5.0 5.0 SHH Np/Cholesterol -0.019 0.076 0.202 1.0 -0.235 47.0 48.0 PTCH1 -0.017 0.117 -9999.0 0.0 -0.345 46.0 46.0 HHIP -0.058 0.16 -9999.0 0.0 -0.431 66.0 66.0