Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.009 0.081 -9999.0 0.0 -0.221 55.0 55.0 epithelial cell differentiation 0.025 0.085 -9999.0 0.0 -0.219 48.0 48.0 CYFIP2 0.023 0.033 -9999.0 0.0 -0.249 5.0 5.0 ENAH -0.024 0.06 0.271 3.0 -9999.0 0.0 3.0 EGFR -0.013 0.119 -9999.0 0.0 -0.431 34.0 34.0 EPHA2 0.011 0.046 -9999.0 0.0 -0.431 2.0 2.0 MYO6 -0.013 0.078 -9999.0 0.0 -0.212 44.0 44.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.025 -9999.0 0.0 -0.236 2.0 2.0 AQP5 -0.064 0.166 -9999.0 0.0 -0.444 63.0 63.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.076 -9999.0 0.0 -0.209 44.0 44.0 regulation of calcium-dependent cell-cell adhesion -0.016 0.081 0.176 16.0 -0.212 52.0 68.0 EGF -0.007 0.108 -9999.0 0.0 -0.431 26.0 26.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.103 -9999.0 0.0 -0.446 17.0 17.0 cortical microtubule organization 0.025 0.085 -9999.0 0.0 -0.219 48.0 48.0 GO:0000145 -0.026 0.068 0.164 17.0 -0.2 44.0 61.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.029 0.088 -9999.0 0.0 -0.221 48.0 48.0 MLLT4 0.024 0.022 -9999.0 0.0 -0.431 1.0 1.0 ARF6/GDP -0.036 0.055 -9999.0 0.0 -0.228 5.0 5.0 ARF6 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.037 -9999.0 0.0 -0.253 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.083 -9999.0 0.0 -0.332 17.0 17.0 PVRL2 0.02 0.024 -9999.0 0.0 -0.279 2.0 2.0 ZYX -0.012 0.067 -9999.0 0.0 -0.213 37.0 37.0 ARF6/GTP 0.058 0.039 -9999.0 0.0 -0.237 3.0 3.0 CDH1 -0.044 0.147 -9999.0 0.0 -0.431 52.0 52.0 EGFR/EGFR/EGF/EGF -0.016 0.115 -9999.0 0.0 -0.237 88.0 88.0 RhoA/GDP 0.027 0.082 -9999.0 0.0 -0.209 48.0 48.0 actin cytoskeleton organization -0.028 0.074 0.166 16.0 -0.211 42.0 58.0 IGF-1R heterotetramer 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.075 -9999.0 0.0 -0.431 12.0 12.0 DIAPH1 0.022 0.121 -9999.0 0.0 -0.596 6.0 6.0 Wnt receptor signaling pathway -0.025 0.085 0.219 48.0 -9999.0 0.0 48.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.037 0.055 -9999.0 0.0 -0.229 5.0 5.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.075 0.167 16.0 -0.215 42.0 58.0 EFNA1 0.024 0.013 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.035 0.074 0.171 14.0 -0.214 9.0 23.0 Ephrin A1/EPHA2 0.015 0.078 -9999.0 0.0 -0.203 46.0 46.0 SEC6/SEC8 -0.014 0.058 -9999.0 0.0 -0.214 19.0 19.0 MGAT3 -0.016 0.082 0.177 16.0 -0.215 52.0 68.0 HGF/MET -0.025 0.116 -9999.0 0.0 -0.241 87.0 87.0 HGF -0.007 0.087 -9999.0 0.0 -0.199 59.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.009 0.082 -9999.0 0.0 -0.222 55.0 55.0 actin cable formation -0.003 0.096 0.403 8.0 -0.257 6.0 14.0 KIAA1543 -0.031 0.073 0.165 11.0 -0.217 48.0 59.0 KIFC3 -0.015 0.078 -9999.0 0.0 -0.216 47.0 47.0 NCK1 0.025 0.022 -9999.0 0.0 -0.431 1.0 1.0 EXOC3 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.018 0.079 -9999.0 0.0 -0.213 46.0 46.0 NCK1/GIT1 0.037 0.017 -9999.0 0.0 -0.307 1.0 1.0 mol:GDP 0.025 0.085 -9999.0 0.0 -0.219 48.0 48.0 EXOC4 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.078 0.177 16.0 -0.212 46.0 62.0 PIP5K1C -0.013 0.077 -9999.0 0.0 -0.212 44.0 44.0 LIMA1 0.019 0.056 -9999.0 0.0 -0.431 7.0 7.0 ABI1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.02 0.082 0.398 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.009 0.088 0.278 9.0 -0.411 4.0 13.0 IGF-1R heterotetramer/IGF1 0.015 0.089 -9999.0 0.0 -0.218 55.0 55.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.028 -9999.0 0.0 -0.307 2.0 2.0 MET -0.047 0.14 -9999.0 0.0 -0.265 106.0 106.0 PLEKHA7 -0.018 0.082 0.194 1.0 -0.227 48.0 49.0 mol:GTP 0.052 0.036 -9999.0 0.0 -0.252 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.02 0.115 0.331 22.0 -0.369 1.0 23.0 cortical actin cytoskeleton stabilization -0.009 0.081 -9999.0 0.0 -0.221 55.0 55.0 regulation of cell-cell adhesion -0.028 0.074 0.166 16.0 -0.211 42.0 58.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.009 0.082 -9999.0 0.0 -0.222 55.0 55.0