Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.073 0.143 -9999.0 0.0 -0.25 9.0 9.0 epithelial cell differentiation -0.051 0.137 -9999.0 0.0 -0.225 9.0 9.0 CYFIP2 0.028 0.032 -9999.0 0.0 -0.131 1.0 1.0 ENAH -0.059 0.085 -9999.0 0.0 -0.386 1.0 1.0 EGFR -0.006 0.118 -9999.0 0.0 -0.315 3.0 3.0 EPHA2 0.024 0.033 -9999.0 0.0 -0.131 1.0 1.0 MYO6 -0.072 0.141 -9999.0 0.0 -0.237 9.0 9.0 CTNNB1 0.001 0.116 -9999.0 0.0 -0.407 2.0 2.0 ABI1/Sra1/Nap1 0.056 0.036 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.047 0.111 -9999.0 0.0 -0.369 1.0 1.0 CTNND1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.056 0.107 0.184 1.0 -0.195 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.064 0.117 0.184 1.0 -0.212 9.0 10.0 EGF 0.021 0.044 -9999.0 0.0 -0.131 2.0 2.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.055 0.132 -9999.0 0.0 -0.402 2.0 2.0 cortical microtubule organization -0.051 0.137 -9999.0 0.0 -0.225 9.0 9.0 GO:0000145 -0.065 0.094 0.169 1.0 -0.187 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.048 0.141 -9999.0 0.0 -0.227 9.0 9.0 MLLT4 0.017 0.084 -9999.0 0.0 -0.407 1.0 1.0 ARF6/GDP -0.072 0.097 -9999.0 0.0 -0.281 2.0 2.0 ARF6 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.063 0.05 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.068 0.109 -9999.0 0.0 -0.294 3.0 3.0 PVRL2 0.011 0.083 -9999.0 0.0 -0.407 1.0 1.0 ZYX -0.059 0.122 0.186 1.0 -0.217 9.0 10.0 ARF6/GTP 0.08 0.039 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.133 0.19 -9999.0 0.0 -0.289 14.0 14.0 EGFR/EGFR/EGF/EGF -0.074 0.128 -9999.0 0.0 -0.214 11.0 11.0 RhoA/GDP -0.051 0.152 -9999.0 0.0 -0.233 9.0 9.0 actin cytoskeleton organization -0.073 0.134 0.173 1.0 -0.231 9.0 10.0 IGF-1R heterotetramer 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.019 0.084 -9999.0 0.0 -0.407 1.0 1.0 DIAPH1 0.024 0.151 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.051 0.137 0.225 9.0 -9999.0 0.0 9.0 RHOA 0.017 0.084 -9999.0 0.0 -0.407 1.0 1.0 RhoA/GTP -0.077 0.117 -9999.0 0.0 -0.535 1.0 1.0 CTNNA1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.075 0.137 0.175 1.0 -0.236 9.0 10.0 EFNA1 0.029 0.032 -9999.0 0.0 -0.131 1.0 1.0 LPP -0.062 0.1 0.177 1.0 -0.198 2.0 3.0 Ephrin A1/EPHA2 -0.056 0.127 -9999.0 0.0 -0.223 7.0 7.0 SEC6/SEC8 -0.074 0.126 -9999.0 0.0 -0.311 3.0 3.0 MGAT3 -0.065 0.119 0.186 1.0 -0.214 9.0 10.0 HGF/MET -0.055 0.127 -9999.0 0.0 -0.216 9.0 9.0 HGF 0.013 0.052 -9999.0 0.0 -0.131 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.073 0.144 -9999.0 0.0 -0.252 9.0 9.0 actin cable formation -0.038 0.085 -9999.0 0.0 -0.257 1.0 1.0 KIAA1543 -0.08 0.096 -9999.0 0.0 -0.205 9.0 9.0 KIFC3 -0.065 0.12 -9999.0 0.0 -0.217 9.0 9.0 NCK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.068 0.119 -9999.0 0.0 -0.217 9.0 9.0 NCK1/GIT1 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.051 0.137 -9999.0 0.0 -0.225 9.0 9.0 EXOC4 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.065 0.12 0.186 1.0 -0.217 9.0 10.0 PIP5K1C -0.057 0.108 0.186 1.0 -0.198 9.0 10.0 LIMA1 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.067 0.105 -9999.0 0.0 -0.462 1.0 1.0 adherens junction assembly -0.041 0.113 0.293 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 -0.055 0.147 -9999.0 0.0 -0.23 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.012 0.088 -9999.0 0.0 -0.287 2.0 2.0 MET 0.025 0.033 -9999.0 0.0 -0.131 1.0 1.0 PLEKHA7 -0.071 0.11 -9999.0 0.0 -0.214 9.0 9.0 mol:GTP 0.061 0.049 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.042 0.154 0.288 1.0 -0.494 1.0 2.0 cortical actin cytoskeleton stabilization -0.073 0.143 -9999.0 0.0 -0.25 9.0 9.0 regulation of cell-cell adhesion -0.073 0.134 0.173 1.0 -0.231 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.073 0.144 -9999.0 0.0 -0.252 9.0 9.0