Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.079 -9999.0 0.0 -0.355 10.0 10.0 epithelial cell differentiation -0.026 0.112 -9999.0 0.0 -0.502 10.0 10.0 CYFIP2 -0.054 0.21 -9999.0 0.0 -0.864 12.0 12.0 ENAH 0.022 0.115 -9999.0 0.0 -0.509 4.0 4.0 EGFR -0.014 0.107 -9999.0 0.0 -0.864 3.0 3.0 EPHA2 -0.036 0.173 -9999.0 0.0 -0.864 8.0 8.0 MYO6 -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.037 0.142 -9999.0 0.0 -0.584 12.0 12.0 AQP5 -0.018 0.093 -9999.0 0.0 -0.418 8.0 8.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.025 0.105 -9999.0 0.0 -0.47 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.125 -9999.0 0.0 -0.47 11.0 11.0 EGF 0.08 0.145 0.341 45.0 -9999.0 0.0 45.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.074 0.202 -9999.0 0.0 -0.671 16.0 16.0 cortical microtubule organization -0.026 0.112 -9999.0 0.0 -0.502 10.0 10.0 GO:0000145 -0.023 0.1 -9999.0 0.0 -0.448 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.027 0.113 -9999.0 0.0 -0.509 10.0 10.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.042 0.146 -9999.0 0.0 -0.785 4.0 4.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.028 0.119 -9999.0 0.0 -0.535 10.0 10.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.023 0.099 -9999.0 0.0 -0.442 10.0 10.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 ARF6/GTP -0.026 0.11 -9999.0 0.0 -0.494 10.0 10.0 CDH1 -0.045 0.192 -9999.0 0.0 -0.864 10.0 10.0 EGFR/EGFR/EGF/EGF -0.004 0.147 -9999.0 0.0 -0.536 11.0 11.0 RhoA/GDP -0.025 0.105 -9999.0 0.0 -0.472 10.0 10.0 actin cytoskeleton organization -0.023 0.1 -9999.0 0.0 -0.448 10.0 10.0 IGF-1R heterotetramer -0.005 0.095 0.34 2.0 -0.862 2.0 4.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.005 0.095 0.341 2.0 -0.864 2.0 4.0 IGF1 -0.335 0.421 -9999.0 0.0 -0.864 74.0 74.0 DIAPH1 -0.052 0.181 -9999.0 0.0 -0.72 13.0 13.0 Wnt receptor signaling pathway 0.026 0.112 0.502 10.0 -9999.0 0.0 10.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.042 0.146 -9999.0 0.0 -0.786 4.0 4.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.024 0.102 -9999.0 0.0 -0.46 10.0 10.0 EFNA1 -0.009 0.088 -9999.0 0.0 -0.864 2.0 2.0 LPP -0.024 0.1 -9999.0 0.0 -0.45 10.0 10.0 Ephrin A1/EPHA2 -0.048 0.17 -9999.0 0.0 -0.577 16.0 16.0 SEC6/SEC8 -0.022 0.094 -9999.0 0.0 -0.423 10.0 10.0 MGAT3 -0.014 0.127 -9999.0 0.0 -0.479 11.0 11.0 HGF/MET -0.243 0.264 -9999.0 0.0 -0.499 93.0 93.0 HGF -0.407 0.431 -9999.0 0.0 -0.864 90.0 90.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.019 0.08 -9999.0 0.0 -0.358 10.0 10.0 actin cable formation 0.029 0.106 -9999.0 0.0 -0.397 6.0 6.0 KIAA1543 -0.036 0.147 -9999.0 0.0 -0.568 12.0 12.0 KIFC3 -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.026 0.112 -9999.0 0.0 -0.502 10.0 10.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 PIP5K1C -0.025 0.107 -9999.0 0.0 -0.478 10.0 10.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.035 0.123 -9999.0 0.0 -0.641 4.0 4.0 adherens junction assembly 0.01 0.148 -9999.0 0.0 -0.647 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.209 0.245 -9999.0 0.0 -0.48 83.0 83.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.002 0.025 0.341 1.0 -9999.0 0.0 1.0 PLEKHA7 -0.03 0.116 -9999.0 0.0 -0.48 12.0 12.0 mol:GTP -0.028 0.118 -9999.0 0.0 -0.531 10.0 10.0 establishment of epithelial cell apical/basal polarity -0.021 0.09 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.019 0.079 -9999.0 0.0 -0.355 10.0 10.0 regulation of cell-cell adhesion -0.023 0.1 -9999.0 0.0 -0.448 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.019 0.08 -9999.0 0.0 -0.358 10.0 10.0