E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.026 0.135 -9999.0 0.0 -0.498 10.0 10.0 KLHL20 -0.008 0.084 -9999.0 0.0 -0.273 6.0 6.0 CYFIP2 -0.016 0.158 -9999.0 0.0 -0.62 12.0 12.0 Rac1/GDP -0.005 0.092 -9999.0 0.0 -0.318 9.0 9.0 ENAH -0.012 0.117 -9999.0 0.0 -0.466 10.0 10.0 AP1M1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.006 0.066 -9999.0 0.0 -0.258 10.0 10.0 ABI1/Sra1/Nap1 -0.032 0.059 -9999.0 0.0 -0.181 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.029 0.107 -9999.0 0.0 -0.367 12.0 12.0 RAPGEF1 -0.023 0.121 -9999.0 0.0 -0.449 10.0 10.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.143 -9999.0 0.0 -0.526 10.0 10.0 CRK -0.018 0.12 -9999.0 0.0 -0.484 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.102 -9999.0 0.0 -0.401 10.0 10.0 alphaE/beta7 Integrin 0.03 0.057 0.256 2.0 -0.455 2.0 4.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.025 0.137 -9999.0 0.0 -0.514 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.009 0.049 -9999.0 0.0 -0.197 11.0 11.0 MLLT4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.032 0.082 -9999.0 0.0 -0.366 7.0 7.0 PI3K -0.008 0.064 -9999.0 0.0 -0.253 11.0 11.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.007 0.113 -9999.0 0.0 -0.464 10.0 10.0 TIAM1 0.001 0.122 -9999.0 0.0 -0.62 7.0 7.0 E-cadherin(dimer)/Ca2+ 0.034 0.093 -9999.0 0.0 -0.349 10.0 10.0 AKT1 -0.012 0.04 -9999.0 0.0 -0.181 1.0 1.0 PIK3R1 0.022 0.047 -9999.0 0.0 -0.62 1.0 1.0 CDH1 -0.011 0.145 -9999.0 0.0 -0.62 10.0 10.0 RhoA/GDP -0.004 0.094 -9999.0 0.0 -0.318 10.0 10.0 actin cytoskeleton organization -0.004 0.062 -9999.0 0.0 -0.196 6.0 6.0 CDC42/GDP -0.001 0.092 -9999.0 0.0 -0.318 10.0 10.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.001 0.068 -9999.0 0.0 -0.284 10.0 10.0 ITGB7 0.019 0.066 -9999.0 0.0 -0.62 2.0 2.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.037 0.098 -9999.0 0.0 -0.369 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.021 0.088 -9999.0 0.0 -0.347 10.0 10.0 mol:GDP -0.019 0.102 -9999.0 0.0 -0.367 10.0 10.0 CDC42/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.002 0.098 -9999.0 0.0 -0.326 10.0 10.0 RAC1/GTP/IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.068 0.208 1.0 -0.249 10.0 11.0 NME1 0.028 0.034 0.356 2.0 -9999.0 0.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.025 0.137 -9999.0 0.0 -0.514 10.0 10.0 regulation of cell-cell adhesion 0.001 0.057 -9999.0 0.0 -0.228 10.0 10.0 WASF2 -0.006 0.039 -9999.0 0.0 -0.128 2.0 2.0 Rap1/GTP 0.009 0.078 -9999.0 0.0 -0.287 10.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.106 -9999.0 0.0 -0.349 12.0 12.0 CCND1 -0.011 0.084 0.236 1.0 -0.314 10.0 11.0 VAV2 -0.035 0.174 -9999.0 0.0 -0.507 18.0 18.0 RAP1/GDP 0.006 0.083 -9999.0 0.0 -0.292 10.0 10.0 adherens junction assembly -0.023 0.133 -9999.0 0.0 -0.496 10.0 10.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.025 0.099 -9999.0 0.0 -0.338 12.0 12.0 E-cadherin/beta catenin -0.011 0.096 -9999.0 0.0 -0.414 10.0 10.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.026 0.139 -9999.0 0.0 -0.514 10.0 10.0 PIK3CA 0.022 0.047 -9999.0 0.0 -0.62 1.0 1.0 Rac1/GTP -0.042 0.135 -9999.0 0.0 -0.448 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.023 0.102 -9999.0 0.0 -0.401 10.0 10.0 ITGAE 0.026 0.035 0.356 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.146 -9999.0 0.0 -0.539 10.0 10.0