Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.006 0.068 -9999.0 0.0 -0.277 10.0 10.0 epithelial cell differentiation 0.029 0.09 -9999.0 0.0 -0.345 10.0 10.0 CYFIP2 -0.016 0.158 -9999.0 0.0 -0.62 12.0 12.0 ENAH -0.014 0.083 0.273 1.0 -0.407 3.0 4.0 EGFR 0.014 0.081 -9999.0 0.0 -0.62 3.0 3.0 EPHA2 0.003 0.109 -9999.0 0.0 -0.53 7.0 7.0 MYO6 -0.025 0.076 -9999.0 0.0 -0.334 10.0 10.0 CTNNB1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.105 -9999.0 0.0 -0.368 12.0 12.0 AQP5 0.0 0.068 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.025 0.075 -9999.0 0.0 -0.329 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.096 -9999.0 0.0 -0.329 11.0 11.0 EGF 0.095 0.141 0.356 42.0 -9999.0 0.0 42.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.052 0.171 -9999.0 0.0 -0.568 15.0 15.0 cortical microtubule organization 0.029 0.09 -9999.0 0.0 -0.345 10.0 10.0 GO:0000145 -0.024 0.072 -9999.0 0.0 -0.314 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.034 0.093 -9999.0 0.0 -0.349 10.0 10.0 MLLT4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.092 -9999.0 0.0 -0.395 10.0 10.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.033 0.078 -9999.0 0.0 -0.369 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.073 -9999.0 0.0 -0.306 10.0 10.0 PVRL2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.076 -9999.0 0.0 -0.334 10.0 10.0 ARF6/GTP 0.038 0.076 -9999.0 0.0 -0.347 5.0 5.0 CDH1 -0.011 0.145 -9999.0 0.0 -0.62 10.0 10.0 EGFR/EGFR/EGF/EGF 0.04 0.113 -9999.0 0.0 -0.391 8.0 8.0 RhoA/GDP 0.031 0.087 -9999.0 0.0 -0.331 10.0 10.0 actin cytoskeleton organization -0.024 0.071 -9999.0 0.0 -0.325 9.0 9.0 IGF-1R heterotetramer 0.021 0.075 0.356 2.0 -0.619 2.0 4.0 GIT1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.021 0.075 0.356 2.0 -0.62 2.0 4.0 IGF1 -0.23 0.315 -9999.0 0.0 -0.62 74.0 74.0 DIAPH1 -0.012 0.179 -9999.0 0.0 -0.609 15.0 15.0 Wnt receptor signaling pathway -0.029 0.09 0.345 10.0 -9999.0 0.0 10.0 RHOA 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.037 0.092 -9999.0 0.0 -0.397 10.0 10.0 CTNNA1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.024 0.073 -9999.0 0.0 -0.332 9.0 9.0 EFNA1 0.012 0.067 -9999.0 0.0 -0.62 2.0 2.0 LPP -0.026 0.073 -9999.0 0.0 -0.321 10.0 10.0 Ephrin A1/EPHA2 0.007 0.114 -9999.0 0.0 -0.432 10.0 10.0 SEC6/SEC8 -0.029 0.068 -9999.0 0.0 -0.313 10.0 10.0 MGAT3 -0.013 0.097 -9999.0 0.0 -0.335 11.0 11.0 HGF/MET -0.14 0.203 -9999.0 0.0 -0.352 85.0 85.0 HGF -0.267 0.319 -9999.0 0.0 -0.616 85.0 85.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.006 0.068 -9999.0 0.0 -0.279 10.0 10.0 actin cable formation 0.027 0.112 0.411 3.0 -0.322 3.0 6.0 KIAA1543 -0.028 0.075 -9999.0 0.0 -0.32 11.0 11.0 KIFC3 -0.026 0.076 -9999.0 0.0 -0.334 10.0 10.0 NCK1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.076 -9999.0 0.0 -0.334 10.0 10.0 NCK1/GIT1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.029 0.09 -9999.0 0.0 -0.345 10.0 10.0 EXOC4 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.025 0.076 -9999.0 0.0 -0.334 10.0 10.0 PIP5K1C -0.025 0.076 -9999.0 0.0 -0.334 10.0 10.0 LIMA1 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.119 0.343 3.0 -0.462 4.0 7.0 adherens junction assembly -0.025 0.084 -9999.0 0.0 -0.343 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.122 0.193 -9999.0 0.0 -0.339 79.0 79.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.029 0.079 -9999.0 0.0 -0.335 11.0 11.0 mol:GTP 0.031 0.077 -9999.0 0.0 -0.367 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.012 0.092 0.317 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.006 0.068 -9999.0 0.0 -0.277 10.0 10.0 regulation of cell-cell adhesion -0.024 0.071 -9999.0 0.0 -0.325 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.006 0.068 -9999.0 0.0 -0.279 10.0 10.0