Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within Glypican 2 network 186.0 746.0 4.0 -0.206 -0.132 1000.0 -1000.0 -0.03 -1000.0 Angiopoietin receptor Tie2-mediated signaling 142.0 12526.0 88.0 -0.603 0.057 1000.0 -1000.0 -0.094 -1000.0 FOXM1 transcription factor network 135.0 6904.0 51.0 -0.562 0.01 1000.0 -1000.0 -0.182 -1000.0 Aurora B signaling 122.0 8215.0 67.0 -0.413 0.01 1000.0 -1000.0 -0.056 -1000.0 Signaling events mediated by the Hedgehog family 97.0 5065.0 52.0 -0.369 0.177 1000.0 -1000.0 -0.071 -1000.0 HIF-1-alpha transcription factor network 74.0 5644.0 76.0 -0.491 0.016 1000.0 -1000.0 -0.148 -1000.0 Aurora C signaling 74.0 519.0 7.0 -0.266 0.005 1000.0 -1000.0 -0.036 -1000.0 PLK1 signaling events 65.0 5545.0 85.0 -0.299 0.06 1000.0 -1000.0 -0.042 -1000.0 Visual signal transduction: Cones 64.0 2453.0 38.0 -0.17 0.01 1000.0 -1000.0 -0.052 -1000.0 Endothelins 63.0 6068.0 96.0 -0.303 0.022 1000.0 -1000.0 -0.08 -1000.0 Signaling mediated by p38-alpha and p38-beta 63.0 2781.0 44.0 -0.115 0.01 1000.0 -1000.0 -0.046 -1000.0 Osteopontin-mediated events 56.0 2142.0 38.0 -0.36 0.011 1000.0 -1000.0 -0.091 -1000.0 IL4-mediated signaling events 55.0 5010.0 91.0 -0.787 0.517 1000.0 -1000.0 -0.167 -1000.0 BMP receptor signaling 52.0 4271.0 81.0 -0.352 0.027 1000.0 -1000.0 -0.079 -1000.0 amb2 Integrin signaling 51.0 4247.0 82.0 -0.463 0.01 1000.0 -1000.0 -0.068 -1000.0 Signaling events regulated by Ret tyrosine kinase 48.0 3999.0 82.0 -0.159 0.01 1000.0 -1000.0 -0.077 -1000.0 Fc-epsilon receptor I signaling in mast cells 47.0 4576.0 97.0 -0.146 0.028 1000.0 -1000.0 -0.072 -1000.0 TCGA08_retinoblastoma 45.0 366.0 8.0 -0.153 0.05 1000.0 -1000.0 -0.023 -1000.0 FOXA2 and FOXA3 transcription factor networks 43.0 2016.0 46.0 -0.494 0.016 1000.0 -1000.0 -0.101 -1000.0 TCGA08_p53 42.0 294.0 7.0 -0.105 0.054 1000.0 -1000.0 -0.011 -1000.0 Visual signal transduction: Rods 42.0 2213.0 52.0 -0.15 0.01 1000.0 -1000.0 -0.076 -1000.0 Glucocorticoid receptor regulatory network 41.0 4771.0 114.0 -0.417 0.25 1000.0 -1000.0 -0.066 -1000.0 Syndecan-1-mediated signaling events 39.0 1339.0 34.0 -0.339 0.01 1000.0 -1000.0 -0.048 -1000.0 p75(NTR)-mediated signaling 37.0 4654.0 125.0 -0.294 0.019 1000.0 -1000.0 -0.08 -1000.0 LPA4-mediated signaling events 36.0 436.0 12.0 -0.12 0.013 1000.0 -1000.0 -0.02 -1000.0 Canonical Wnt signaling pathway 35.0 1822.0 51.0 -0.343 0.148 1000.0 -1000.0 -0.053 -1000.0 Thromboxane A2 receptor signaling 33.0 3518.0 105.0 -0.089 0.029 1000.0 -1000.0 -0.057 -1000.0 Glypican 1 network 33.0 1584.0 48.0 -0.116 0.019 1000.0 -1000.0 -0.044 -1000.0 Arf6 signaling events 32.0 2029.0 62.0 -0.187 0.012 1000.0 -1000.0 -0.058 -1000.0 Effects of Botulinum toxin 32.0 839.0 26.0 -0.09 0.01 1000.0 -1000.0 -0.052 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 32.0 3862.0 120.0 -0.254 0.196 1000.0 -1000.0 -0.057 -1000.0 Integrins in angiogenesis 31.0 2635.0 84.0 -0.363 0.025 1000.0 -1000.0 -0.08 -1000.0 Aurora A signaling 30.0 1822.0 60.0 -0.294 0.015 1000.0 -1000.0 -0.049 -1000.0 Ephrin B reverse signaling 30.0 1459.0 48.0 -0.093 0.054 1000.0 -1000.0 -0.057 -1000.0 ErbB4 signaling events 29.0 2050.0 69.0 -0.191 0.208 1000.0 -1000.0 -0.075 -1000.0 IL6-mediated signaling events 27.0 2041.0 75.0 -0.33 0.042 1000.0 -1000.0 -0.09 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 27.0 1892.0 68.0 -0.136 0.028 1000.0 -1000.0 -0.129 -1000.0 Presenilin action in Notch and Wnt signaling 26.0 1618.0 61.0 -0.344 0.021 1000.0 -1000.0 -0.059 -1000.0 IL23-mediated signaling events 26.0 1573.0 60.0 -0.277 0.015 1000.0 -1000.0 -0.173 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 24.0 807.0 33.0 -0.147 0.025 1000.0 -1000.0 -0.054 -1000.0 EGFR-dependent Endothelin signaling events 23.0 500.0 21.0 -0.089 0.01 1000.0 -1000.0 -0.063 -1000.0 PDGFR-alpha signaling pathway 22.0 1009.0 44.0 -0.316 0.027 1000.0 -1000.0 -0.054 -1000.0 Nongenotropic Androgen signaling 22.0 1155.0 52.0 -0.057 0.01 1000.0 -1000.0 -0.047 -1000.0 Wnt signaling 21.0 147.0 7.0 -0.059 0.009 1000.0 -1000.0 -0.03 -1000.0 Class IB PI3K non-lipid kinase events 21.0 63.0 3.0 -0.012 -1000.0 1000.0 -1000.0 -0.014 -1000.0 Syndecan-3-mediated signaling events 20.0 725.0 35.0 -0.203 0.01 1000.0 -1000.0 -0.053 -1000.0 HIF-2-alpha transcription factor network 19.0 818.0 43.0 -0.127 0.064 1000.0 -1000.0 -0.094 -1000.0 Regulation of Androgen receptor activity 19.0 1391.0 70.0 -0.261 0.027 1000.0 -1000.0 -0.057 -1000.0 PLK2 and PLK4 events 18.0 54.0 3.0 -0.018 -0.003 1000.0 -1000.0 -0.024 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 18.0 947.0 52.0 -0.258 0.044 1000.0 -1000.0 -0.052 -1000.0 Syndecan-2-mediated signaling events 17.0 1233.0 69.0 -0.096 0.032 1000.0 -1000.0 -0.044 -1000.0 Reelin signaling pathway 17.0 990.0 56.0 -0.095 0.01 1000.0 -1000.0 -0.071 -1000.0 Coregulation of Androgen receptor activity 16.0 1270.0 76.0 -0.147 0.018 1000.0 -1000.0 -0.038 -1000.0 Nectin adhesion pathway 16.0 1020.0 63.0 -0.041 0.013 1000.0 -1000.0 -0.066 -1000.0 Syndecan-4-mediated signaling events 16.0 1136.0 67.0 -0.169 0.016 1000.0 -1000.0 -0.079 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 15.0 543.0 34.0 -0.04 0.01 1000.0 -1000.0 -0.052 -1000.0 Noncanonical Wnt signaling pathway 15.0 400.0 26.0 -0.059 0.01 1000.0 -1000.0 -0.078 -1000.0 Caspase cascade in apoptosis 13.0 1011.0 74.0 -0.041 0.032 1000.0 -1000.0 -0.037 -1000.0 IL12-mediated signaling events 13.0 1175.0 87.0 -0.097 0.038 1000.0 -1000.0 -0.13 -1000.0 Signaling events mediated by PTP1B 13.0 1037.0 76.0 -0.092 0.017 1000.0 -1000.0 -0.075 -1000.0 Signaling events mediated by HDAC Class III 13.0 526.0 40.0 -0.114 0.018 1000.0 -1000.0 -0.034 -1000.0 FAS signaling pathway (CD95) 13.0 617.0 47.0 -0.243 0.012 1000.0 -1000.0 -0.043 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 13.0 1675.0 125.0 -0.316 0.034 1000.0 -1000.0 -0.091 -1000.0 LPA receptor mediated events 13.0 1363.0 102.0 -0.121 0.03 1000.0 -1000.0 -0.079 -1000.0 BCR signaling pathway 13.0 1372.0 99.0 -0.131 0.026 1000.0 -1000.0 -0.076 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 13.0 1057.0 78.0 -0.039 0.038 1000.0 -1000.0 -0.076 -1000.0 S1P1 pathway 12.0 465.0 36.0 -0.063 0.011 1000.0 -1000.0 -0.053 -1000.0 TCR signaling in naïve CD8+ T cells 12.0 1148.0 93.0 -0.075 0.043 1000.0 -1000.0 -0.071 -1000.0 Signaling events mediated by PRL 12.0 429.0 34.0 -0.182 0.021 1000.0 -1000.0 -0.046 -1000.0 BARD1 signaling events 11.0 656.0 57.0 -0.182 0.03 1000.0 -1000.0 -0.053 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 11.0 604.0 54.0 -0.135 0.021 1000.0 -1000.0 -0.085 -1000.0 Ephrin A reverse signaling 11.0 77.0 7.0 -0.01 0.008 1000.0 -1000.0 -0.027 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 11.0 989.0 85.0 -0.041 0.03 1000.0 -1000.0 -0.068 -1000.0 IL1-mediated signaling events 11.0 696.0 62.0 -0.148 0.049 1000.0 -1000.0 -0.082 -1000.0 S1P5 pathway 11.0 199.0 17.0 -0.033 0.03 1000.0 -1000.0 -0.045 -1000.0 EPHB forward signaling 11.0 1003.0 85.0 -0.066 0.049 1000.0 -1000.0 -0.073 -1000.0 Calcium signaling in the CD4+ TCR pathway 11.0 359.0 31.0 -0.073 0.012 1000.0 -1000.0 -0.083 -1000.0 ErbB2/ErbB3 signaling events 10.0 653.0 65.0 -0.095 0.019 1000.0 -1000.0 -0.06 -1000.0 S1P4 pathway 10.0 254.0 25.0 -0.033 0.011 1000.0 -1000.0 -0.048 -1000.0 Regulation of p38-alpha and p38-beta 9.0 518.0 54.0 -0.075 0.018 1000.0 -1000.0 -0.055 -1000.0 IL2 signaling events mediated by STAT5 9.0 204.0 22.0 -0.119 0.055 1000.0 -1000.0 -0.06 -1000.0 Regulation of nuclear SMAD2/3 signaling 8.0 1167.0 136.0 -0.107 0.051 1000.0 -1000.0 -0.064 -1000.0 Plasma membrane estrogen receptor signaling 8.0 759.0 86.0 -0.035 0.03 1000.0 -1000.0 -0.068 -1000.0 Regulation of Telomerase 7.0 721.0 102.0 -0.092 0.03 1000.0 -1000.0 -0.096 -1000.0 VEGFR1 specific signals 7.0 392.0 56.0 -0.316 0.042 1000.0 -1000.0 -0.067 -1000.0 Ras signaling in the CD4+ TCR pathway 7.0 133.0 17.0 -0.014 0.021 1000.0 -1000.0 -0.038 -1000.0 Sphingosine 1-phosphate (S1P) pathway 6.0 180.0 28.0 -0.033 0.021 1000.0 -1000.0 -0.051 -1000.0 Cellular roles of Anthrax toxin 6.0 238.0 39.0 -0.045 0.015 1000.0 -1000.0 -0.026 -1000.0 Signaling mediated by p38-gamma and p38-delta 6.0 96.0 15.0 -0.0 0.022 1000.0 -1000.0 -0.034 -1000.0 Retinoic acid receptors-mediated signaling 6.0 361.0 58.0 -0.172 0.032 1000.0 -1000.0 -0.064 -1000.0 IL27-mediated signaling events 6.0 351.0 51.0 -0.107 0.011 1000.0 -1000.0 -0.086 -1000.0 Arf6 trafficking events 6.0 465.0 71.0 -0.081 0.034 1000.0 -1000.0 -0.064 -1000.0 Insulin Pathway 6.0 483.0 74.0 -0.153 0.03 1000.0 -1000.0 -0.08 -1000.0 p38 MAPK signaling pathway 6.0 287.0 44.0 -0.082 0.025 1000.0 -1000.0 -0.059 -1000.0 Signaling events mediated by HDAC Class II 5.0 403.0 75.0 -0.046 0.027 1000.0 -1000.0 -0.056 -1000.0 JNK signaling in the CD4+ TCR pathway 5.0 90.0 17.0 -0.013 0.031 1000.0 -1000.0 -0.049 -1000.0 Hedgehog signaling events mediated by Gli proteins 5.0 387.0 65.0 -0.174 0.054 1000.0 -1000.0 -0.055 -1000.0 Ceramide signaling pathway 5.0 425.0 76.0 -0.089 0.036 1000.0 -1000.0 -0.057 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 5.0 433.0 83.0 -0.067 0.04 1000.0 -1000.0 -0.072 -1000.0 Class I PI3K signaling events 5.0 374.0 73.0 -0.075 0.023 1000.0 -1000.0 -0.054 -1000.0 IFN-gamma pathway 4.0 315.0 68.0 -0.082 0.047 1000.0 -1000.0 -0.085 -1000.0 Signaling events mediated by HDAC Class I 4.0 449.0 104.0 -0.046 0.043 1000.0 -1000.0 -0.062 -1000.0 FoxO family signaling 4.0 297.0 64.0 -0.126 0.055 1000.0 -1000.0 -0.077 -1000.0 IL2 signaling events mediated by PI3K 4.0 267.0 58.0 -0.148 0.066 1000.0 -1000.0 -0.081 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 4.0 363.0 74.0 -0.113 0.06 1000.0 -1000.0 -0.078 -1000.0 Circadian rhythm pathway 3.0 79.0 22.0 -0.029 0.034 1000.0 -1000.0 -0.065 -1000.0 Arf6 downstream pathway 3.0 164.0 43.0 -0.039 0.026 1000.0 -1000.0 -0.039 -1000.0 TCGA08_rtk_signaling 3.0 97.0 26.0 -0.023 0.037 1000.0 -1000.0 -0.019 -1000.0 IGF1 pathway 3.0 218.0 57.0 -0.037 0.04 1000.0 -1000.0 -0.083 -1000.0 S1P3 pathway 3.0 159.0 42.0 -0.032 0.023 1000.0 -1000.0 -0.05 -1000.0 TRAIL signaling pathway 2.0 112.0 48.0 -0.008 0.04 1000.0 -1000.0 -0.065 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 2.0 117.0 45.0 -0.012 0.062 1000.0 -1000.0 -0.081 -1000.0 E-cadherin signaling in the nascent adherens junction 2.0 181.0 76.0 -0.041 0.05 1000.0 -1000.0 -0.07 -1000.0 Rapid glucocorticoid signaling 2.0 59.0 20.0 -0.007 0.01 1000.0 -1000.0 -0.031 -1000.0 PDGFR-beta signaling pathway 2.0 221.0 97.0 -0.036 0.048 1000.0 -1000.0 -0.076 -1000.0 Canonical NF-kappaB pathway 1.0 44.0 39.0 -0.014 0.066 1000.0 -1000.0 -0.078 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 8.0 5.0 -0.002 0.009 1000.0 -1000.0 -0.031 -1000.0 EPO signaling pathway 1.0 87.0 55.0 -0.006 0.058 1000.0 -1000.0 -0.083 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 1.0 52.0 37.0 -0.005 0.037 1000.0 -1000.0 -0.048 -1000.0 ceramide signaling pathway 1.0 55.0 49.0 -0.012 0.04 1000.0 -1000.0 -0.047 -1000.0 E-cadherin signaling events 1.0 8.0 5.0 -0.002 0.01 1000.0 -1000.0 -0.036 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 11.0 23.0 -0.003 0.036 1000.0 -1000.0 -0.059 -1000.0 Insulin-mediated glucose transport 0.0 24.0 32.0 -0.003 0.035 1000.0 -1000.0 -0.06 -1000.0 mTOR signaling pathway 0.0 17.0 53.0 -0.001 0.026 1000.0 -1000.0 -0.052 -1000.0 Class I PI3K signaling events mediated by Akt 0.0 25.0 68.0 -0.034 0.046 1000.0 -1000.0 -0.055 -1000.0 Paxillin-dependent events mediated by a4b1 0.0 19.0 36.0 -0.003 0.018 1000.0 -1000.0 -0.059 -1000.0 Atypical NF-kappaB pathway 0.0 17.0 31.0 -0.002 0.038 1000.0 -1000.0 -0.053 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 0.0 11.0 27.0 -0.001 0.024 1000.0 -1000.0 -0.046 -1000.0 E-cadherin signaling in keratinocytes 0.0 29.0 43.0 -0.007 0.037 1000.0 -1000.0 -0.056 -1000.0 Arf1 pathway 0.0 20.0 54.0 -0.006 0.024 1000.0 -1000.0 -0.037 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 -0.0 0.01 1000.0 -1000.0 -0.058 -1000.0 Total 2926 169109 7203 -18.5403954466 -995.19694686 131000 -131000 -8.32995988643 -131000