E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.07 -9999.0 0.0 -0.305 23.0 23.0 KLHL20 -0.002 0.053 0.164 2.0 -0.205 13.0 15.0 CYFIP2 0.016 0.041 -9999.0 0.0 -0.321 7.0 7.0 Rac1/GDP -0.011 0.061 0.282 5.0 -0.253 8.0 13.0 ENAH -0.006 0.071 -9999.0 0.0 -0.306 24.0 24.0 AP1M1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.015 0.028 -9999.0 0.0 -0.139 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.026 -9999.0 0.0 -0.172 3.0 3.0 RAPGEF1 -0.01 0.059 0.213 2.0 -0.281 14.0 16.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.001 0.073 -9999.0 0.0 -0.309 25.0 25.0 CRK -0.01 0.053 -9999.0 0.0 -0.295 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.193 2.0 2.0 alphaE/beta7 Integrin 0.028 0.015 -9999.0 0.0 -0.226 1.0 1.0 IQGAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.034 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.067 -9999.0 0.0 -0.309 21.0 21.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.025 0.015 -9999.0 0.0 -0.13 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.054 0.21 40.0 -0.169 5.0 45.0 PI3K -0.03 0.019 -9999.0 0.0 -0.164 2.0 2.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.018 -9999.0 0.0 -0.226 2.0 2.0 TIAM1 0.016 0.038 -9999.0 0.0 -0.321 6.0 6.0 E-cadherin(dimer)/Ca2+ 0.045 0.02 -9999.0 0.0 -0.157 2.0 2.0 AKT1 -0.017 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 CDH1 0.019 0.022 -9999.0 0.0 -0.321 2.0 2.0 RhoA/GDP -0.012 0.063 0.282 5.0 -0.249 8.0 13.0 actin cytoskeleton organization 0.002 0.046 0.165 10.0 -0.154 11.0 21.0 CDC42/GDP -0.012 0.063 0.282 5.0 -0.254 9.0 14.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.009 0.013 -9999.0 0.0 -0.186 2.0 2.0 ITGB7 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 RAC1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.021 -9999.0 0.0 -0.168 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.034 0.016 -9999.0 0.0 -0.152 2.0 2.0 mol:GDP -0.012 0.069 0.293 5.0 -0.289 9.0 14.0 CDC42/GTP/IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.06 0.228 2.0 -0.255 5.0 7.0 RAC1/GTP/IQGAP1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.006 0.037 0.136 11.0 -0.139 6.0 17.0 NME1 0.048 0.086 0.319 44.0 -9999.0 0.0 44.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.0 0.057 -9999.0 0.0 -0.305 14.0 14.0 regulation of cell-cell adhesion -0.024 0.018 -9999.0 0.0 -0.148 2.0 2.0 WASF2 -0.004 0.023 -9999.0 0.0 -0.093 1.0 1.0 Rap1/GTP -0.023 0.029 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.031 -9999.0 0.0 -0.172 3.0 3.0 CCND1 0.007 0.043 0.148 10.0 -0.157 9.0 19.0 VAV2 -0.011 0.129 -9999.0 0.0 -0.567 20.0 20.0 RAP1/GDP -0.019 0.044 0.195 1.0 -0.226 4.0 5.0 adherens junction assembly 0.0 0.055 -9999.0 0.0 -0.297 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.036 0.026 -9999.0 0.0 -0.164 3.0 3.0 E-cadherin/beta catenin 0.004 0.02 -9999.0 0.0 -0.275 2.0 2.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.07 -9999.0 0.0 -0.306 23.0 23.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.007 0.068 -9999.0 0.0 -0.321 16.0 16.0 E-cadherin/beta catenin/alpha catenin 0.039 0.019 -9999.0 0.0 -0.182 2.0 2.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.075 -9999.0 0.0 -0.315 25.0 25.0