Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.036 0.059 0.236 6.0 -0.229 29.0 35.0 KIRREL 0.017 0.04 -9999.0 0.0 -0.33 6.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.037 0.059 0.23 29.0 -0.236 6.0 35.0 PLCG1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.051 0.056 0.216 29.0 -0.178 6.0 35.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.015 0.039 0.159 2.0 -0.212 6.0 8.0 FYN 0.017 0.082 0.204 66.0 -0.171 6.0 72.0 mol:Ca2+ 0.048 0.054 0.209 28.0 -0.174 6.0 34.0 mol:DAG 0.049 0.054 0.213 28.0 -0.174 6.0 34.0 NPHS2 -0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.049 0.054 0.213 28.0 -0.174 6.0 34.0 regulation of endocytosis 0.037 0.048 0.196 25.0 -0.166 6.0 31.0 Nephrin/NEPH1/podocin/Cholesterol 0.041 0.052 0.202 29.0 -0.172 6.0 35.0 establishment of cell polarity 0.036 0.059 0.229 29.0 -0.236 6.0 35.0 Nephrin/NEPH1/podocin/NCK1-2 0.061 0.056 0.278 1.0 -0.163 6.0 7.0 Nephrin/NEPH1/beta Arrestin2 0.039 0.05 0.203 25.0 -0.167 6.0 31.0 NPHS1 0.041 0.083 0.328 35.0 -9999.0 0.0 35.0 Nephrin/NEPH1/podocin 0.039 0.05 0.201 29.0 -0.172 6.0 35.0 TJP1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.051 0.055 0.217 28.0 -0.175 6.0 34.0 CD2AP 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.051 0.055 0.216 28.0 -0.178 6.0 34.0 GRB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.008 0.094 0.256 42.0 -0.177 27.0 69.0 cytoskeleton organization -0.003 0.051 0.226 9.0 -0.217 6.0 15.0 Nephrin/NEPH1 0.031 0.046 0.188 29.0 -0.157 6.0 35.0 Nephrin/NEPH1/ZO-1 0.041 0.051 0.214 25.0 -0.188 6.0 31.0