Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.089 0.18 0.304 6.0 -0.493 42.0 48.0 IHH -0.013 0.123 0.27 7.0 -0.369 42.0 49.0 SHH Np/Cholesterol/GAS1 -0.011 0.066 -9999.0 0.0 -0.179 62.0 62.0 LRPAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.035 0.056 0.178 62.0 -0.111 1.0 63.0 SMO/beta Arrestin2 -0.142 0.181 0.291 3.0 -0.324 186.0 189.0 SMO -0.145 0.184 0.337 1.0 -0.333 196.0 197.0 AKT1 -0.078 0.138 0.26 1.0 -0.494 28.0 29.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 ADRBK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.144 0.182 0.336 1.0 -0.329 196.0 197.0 STIL -0.083 0.141 0.26 11.0 -0.318 60.0 71.0 DHH N/PTCH2 0.011 0.069 -9999.0 0.0 -0.225 38.0 38.0 DHH N/PTCH1 -0.106 0.151 -9999.0 0.0 -0.235 235.0 235.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.092 -9999.0 0.0 -0.321 38.0 38.0 PTHLH -0.122 0.219 0.368 6.0 -0.546 41.0 47.0 determination of left/right symmetry -0.144 0.182 0.336 1.0 -0.329 196.0 197.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 skeletal system development -0.121 0.218 0.367 6.0 -0.542 41.0 47.0 IHH N/Hhip -0.217 0.177 0.206 3.0 -0.311 355.0 358.0 DHH N/Hhip -0.121 0.142 -9999.0 0.0 -0.244 268.0 268.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.144 0.182 0.336 1.0 -0.329 196.0 197.0 pancreas development -0.163 0.17 -9999.0 0.0 -0.32 261.0 261.0 HHAT 0.018 0.023 -9999.0 0.0 -0.321 2.0 2.0 PI3K 0.029 0.014 -9999.0 0.0 -0.226 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.053 -9999.0 0.0 -0.321 12.0 12.0 somite specification -0.144 0.182 0.336 1.0 -0.329 196.0 197.0 SHH Np/Cholesterol/PTCH1 -0.094 0.137 -9999.0 0.0 -0.33 66.0 66.0 SHH Np/Cholesterol/PTCH2 -0.009 0.061 -9999.0 0.0 -0.173 57.0 57.0 SHH Np/Cholesterol/Megalin -0.048 0.097 -9999.0 0.0 -0.19 145.0 145.0 SHH -0.039 0.069 0.152 1.0 -0.226 57.0 58.0 catabolic process -0.105 0.158 0.227 2.0 -0.248 231.0 233.0 SMO/Vitamin D3 -0.115 0.174 0.373 3.0 -0.405 60.0 63.0 SHH Np/Cholesterol/Hhip -0.09 0.111 -9999.0 0.0 -0.196 238.0 238.0 LRP2 -0.067 0.151 0.319 1.0 -0.321 126.0 127.0 receptor-mediated endocytosis -0.159 0.183 0.3 2.0 -0.407 121.0 123.0 SHH Np/Cholesterol/BOC -0.008 0.06 -9999.0 0.0 -0.173 56.0 56.0 SHH Np/Cholesterol/CDO -0.01 0.064 -9999.0 0.0 -0.177 60.0 60.0 mesenchymal cell differentiation 0.102 0.099 0.195 238.0 -0.111 1.0 239.0 mol:Vitamin D3 -0.089 0.15 0.384 5.0 -0.341 61.0 66.0 IHH N/PTCH2 -0.093 0.127 0.206 4.0 -0.207 262.0 266.0 CDON 0.014 0.046 -9999.0 0.0 -0.321 9.0 9.0 IHH N/PTCH1 -0.097 0.17 0.265 2.0 -0.25 233.0 235.0 Megalin/LRPAP1 -0.034 0.112 0.231 1.0 -0.225 123.0 124.0 PTCH2 0.02 0.016 -9999.0 0.0 -0.321 1.0 1.0 SHH Np/Cholesterol -0.028 0.051 -9999.0 0.0 -0.167 57.0 57.0 PTCH1 -0.105 0.159 0.228 2.0 -0.249 231.0 233.0 HHIP -0.163 0.17 -9999.0 0.0 -0.321 261.0 261.0