Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	218.0	11120.0	51.0	-0.03	0.762	1000.0	-1000.0	-0.067	-1000.0
Glypican 2 network	171.0	687.0	4.0	0.094	0.137	1000.0	-1000.0	0.019	-1000.0
Angiopoietin receptor Tie2-mediated signaling	141.0	12456.0	88.0	-0.569	0.11	1000.0	-1000.0	-0.052	-1000.0
Aurora B signaling	122.0	8224.0	67.0	-0.155	0.275	1000.0	-1000.0	-0.025	-1000.0
HIF-1-alpha transcription factor network	118.0	9040.0	76.0	-0.066	0.43	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by the Hedgehog family	106.0	5522.0	52.0	-0.217	0.102	1000.0	-1000.0	-0.028	-1000.0
Endothelins	80.0	7685.0	96.0	-0.309	0.191	1000.0	-1000.0	-0.039	-1000.0
PLK1 signaling events	71.0	6068.0	85.0	-0.048	0.192	1000.0	-1000.0	-0.021	-1000.0
Aurora C signaling	67.0	474.0	7.0	-0.0	0.165	1000.0	-1000.0	-0.005	-1000.0
Signaling mediated by p38-alpha and p38-beta	65.0	2891.0	44.0	-0.102	0.021	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	61.0	2349.0	38.0	-0.08	0.12	1000.0	-1000.0	-0.017	-1000.0
FOXA2 and FOXA3 transcription factor networks	60.0	2782.0	46.0	-0.201	0.154	1000.0	-1000.0	-0.061	-1000.0
Signaling events regulated by Ret tyrosine kinase	55.0	4560.0	82.0	-0.074	0.061	1000.0	-1000.0	-0.04	-1000.0
Fc-epsilon receptor I signaling in mast cells	53.0	5146.0	97.0	-0.093	0.021	1000.0	-1000.0	-0.035	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	51.0	2682.0	52.0	-0.145	0.045	1000.0	-1000.0	-0.022	-1000.0
Osteopontin-mediated events	50.0	1917.0	38.0	-0.001	0.232	1000.0	-1000.0	-0.018	-1000.0
BMP receptor signaling	50.0	4108.0	81.0	-0.18	0.216	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	49.0	4548.0	91.0	-0.627	0.34	1000.0	-1000.0	-0.093	-1000.0
amb2 Integrin signaling	49.0	4057.0	82.0	-0.288	0.079	1000.0	-1000.0	-0.019	-1000.0
Ephrin B reverse signaling	46.0	2225.0	48.0	-0.074	0.076	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Rods	46.0	2420.0	52.0	-0.08	0.098	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	39.0	4974.0	125.0	-0.15	0.131	1000.0	-1000.0	-0.043	-1000.0
Thromboxane A2 receptor signaling	37.0	3892.0	105.0	-0.121	0.07	1000.0	-1000.0	-0.032	-1000.0
IL23-mediated signaling events	37.0	2225.0	60.0	-0.203	0.027	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	36.0	2499.0	68.0	-0.146	0.064	1000.0	-1000.0	-0.059	-1000.0
Syndecan-1-mediated signaling events	35.0	1195.0	34.0	-0.0	0.207	1000.0	-1000.0	-0.02	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	34.0	4134.0	120.0	-0.163	0.143	1000.0	-1000.0	-0.041	-1000.0
LPA4-mediated signaling events	33.0	397.0	12.0	-0.072	-0.0	1000.0	-1000.0	-0.016	-1000.0
Arf6 signaling events	33.0	2064.0	62.0	-0.105	0.07	1000.0	-1000.0	-0.018	-1000.0
Integrins in angiogenesis	33.0	2799.0	84.0	-0.071	0.228	1000.0	-1000.0	-0.032	-1000.0
Canonical Wnt signaling pathway	33.0	1683.0	51.0	-0.205	0.097	1000.0	-1000.0	-0.026	-1000.0
TCGA08_retinoblastoma	33.0	267.0	8.0	-0.022	0.098	1000.0	-1000.0	-0.003	-1000.0
Presenilin action in Notch and Wnt signaling	32.0	1956.0	61.0	-0.206	0.097	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	32.0	3740.0	114.0	-0.262	0.159	1000.0	-1000.0	-0.041	-1000.0
TCGA08_p53	32.0	227.0	7.0	-0.023	0.019	1000.0	-1000.0	-0.009	-1000.0
Aurora A signaling	31.0	1867.0	60.0	-0.028	0.182	1000.0	-1000.0	-0.015	-1000.0
IL6-mediated signaling events	31.0	2379.0	75.0	-0.149	0.051	1000.0	-1000.0	-0.034	-1000.0
Reelin signaling pathway	30.0	1725.0	56.0	-0.038	0.049	1000.0	-1000.0	-0.019	-1000.0
EGFR-dependent Endothelin signaling events	30.0	637.0	21.0	-0.027	0.07	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	29.0	1268.0	43.0	-0.131	0.137	1000.0	-1000.0	-0.031	-1000.0
Noncanonical Wnt signaling pathway	28.0	752.0	26.0	-0.043	0.038	1000.0	-1000.0	-0.022	-1000.0
Glypican 1 network	28.0	1353.0	48.0	-0.06	0.037	1000.0	-1000.0	-0.024	-1000.0
Effects of Botulinum toxin	27.0	703.0	26.0	-0.0	0.044	1000.0	-1000.0	-0.008	-1000.0
Wnt signaling	27.0	191.0	7.0	-0.021	0.038	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	24.0	1269.0	52.0	-0.062	0.044	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	23.0	1426.0	62.0	-0.082	0.043	1000.0	-1000.0	-0.038	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	775.0	33.0	-0.07	0.096	1000.0	-1000.0	-0.022	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	21.0	720.0	34.0	-0.036	0.061	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	21.0	1506.0	69.0	-0.111	0.146	1000.0	-1000.0	-0.024	-1000.0
PDGFR-alpha signaling pathway	21.0	964.0	44.0	-0.188	0.039	1000.0	-1000.0	-0.033	-1000.0
FoxO family signaling	21.0	1356.0	64.0	0.0	0.191	1000.0	-1000.0	-0.051	-1000.0
LPA receptor mediated events	21.0	2174.0	102.0	-0.058	0.079	1000.0	-1000.0	-0.049	-1000.0
Syndecan-4-mediated signaling events	21.0	1436.0	67.0	-0.043	0.121	1000.0	-1000.0	-0.027	-1000.0
Regulation of Androgen receptor activity	21.0	1536.0	70.0	-0.144	0.127	1000.0	-1000.0	-0.031	-1000.0
Syndecan-2-mediated signaling events	20.0	1397.0	69.0	-0.047	0.053	1000.0	-1000.0	-0.024	-1000.0
Nectin adhesion pathway	20.0	1303.0	63.0	-0.046	0.051	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	19.0	893.0	47.0	-0.235	0.034	1000.0	-1000.0	-0.021	-1000.0
EPHB forward signaling	19.0	1693.0	85.0	-0.032	0.084	1000.0	-1000.0	-0.04	-1000.0
Calcium signaling in the CD4+ TCR pathway	19.0	589.0	31.0	-0.039	0.03	1000.0	-1000.0	-0.032	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	996.0	54.0	-0.034	0.102	1000.0	-1000.0	-0.027	-1000.0
Ceramide signaling pathway	18.0	1369.0	76.0	-0.019	0.07	1000.0	-1000.0	-0.022	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.008	0.008	1000.0	-1000.0	-0.017	-1000.0
S1P4 pathway	18.0	474.0	25.0	-0.019	0.027	1000.0	-1000.0	-0.013	-1000.0
IL12-mediated signaling events	17.0	1501.0	87.0	-0.132	0.057	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PTP1B	17.0	1305.0	76.0	-0.056	0.071	1000.0	-1000.0	-0.033	-1000.0
S1P5 pathway	17.0	295.0	17.0	-0.016	0.021	1000.0	-1000.0	-0.002	-1000.0
Plasma membrane estrogen receptor signaling	17.0	1495.0	86.0	-0.061	0.057	1000.0	-1000.0	-0.031	-1000.0
Caspase cascade in apoptosis	16.0	1197.0	74.0	-0.03	0.086	1000.0	-1000.0	-0.027	-1000.0
Coregulation of Androgen receptor activity	16.0	1239.0	76.0	-0.057	0.096	1000.0	-1000.0	-0.02	-1000.0
PLK2 and PLK4 events	16.0	50.0	3.0	-0.007	0.036	1000.0	-1000.0	-0.014	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	16.0	1369.0	85.0	-0.058	0.035	1000.0	-1000.0	-0.031	-1000.0
TCR signaling in naïve CD8+ T cells	16.0	1550.0	93.0	-0.041	0.034	1000.0	-1000.0	-0.035	-1000.0
ErbB2/ErbB3 signaling events	15.0	975.0	65.0	-0.049	0.03	1000.0	-1000.0	-0.066	-1000.0
BARD1 signaling events	15.0	864.0	57.0	-0.046	0.113	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	14.0	537.0	36.0	-0.09	0.021	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	14.0	1854.0	125.0	-0.188	0.042	1000.0	-1000.0	-0.039	-1000.0
BCR signaling pathway	14.0	1458.0	99.0	-0.049	0.08	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	14.0	1138.0	78.0	-0.038	0.023	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class III	13.0	537.0	40.0	-0.06	0.061	1000.0	-1000.0	-0.035	-1000.0
Syndecan-3-mediated signaling events	13.0	469.0	35.0	-0.117	0.046	1000.0	-1000.0	-0.018	-1000.0
Regulation of p38-alpha and p38-beta	13.0	749.0	54.0	-0.036	0.06	1000.0	-1000.0	-0.037	-1000.0
IL27-mediated signaling events	12.0	643.0	51.0	-0.044	0.03	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PRL	11.0	385.0	34.0	-0.021	0.082	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events	10.0	744.0	73.0	-0.033	0.06	1000.0	-1000.0	-0.021	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1235.0	136.0	-0.171	0.072	1000.0	-1000.0	-0.03	-1000.0
Ephrin A  reverse signaling	9.0	63.0	7.0	-0.012	0.029	1000.0	-1000.0	-0.007	-1000.0
IL2 signaling events mediated by STAT5	9.0	218.0	22.0	-0.024	0.091	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	9.0	669.0	74.0	-0.096	0.051	1000.0	-1000.0	-0.034	-1000.0
VEGFR1 specific signals	9.0	543.0	56.0	-0.188	0.047	1000.0	-1000.0	-0.022	-1000.0
PDGFR-beta signaling pathway	9.0	920.0	97.0	-0.032	0.052	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	149.0	17.0	-0.012	0.047	1000.0	-1000.0	-0.026	-1000.0
Cellular roles of Anthrax toxin	8.0	321.0	39.0	-0.031	0.027	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	524.0	65.0	-0.137	0.048	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	8.0	428.0	53.0	-0.057	0.025	1000.0	-1000.0	-0.038	-1000.0
IFN-gamma pathway	8.0	567.0	68.0	-0.028	0.063	1000.0	-1000.0	-0.035	-1000.0
Retinoic acid receptors-mediated signaling	8.0	493.0	58.0	-0.094	0.046	1000.0	-1000.0	-0.028	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	8.0	632.0	74.0	-0.086	0.07	1000.0	-1000.0	-0.048	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	150.0	17.0	-0.004	0.031	1000.0	-1000.0	-0.01	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	196.0	28.0	-0.015	0.034	1000.0	-1000.0	-0.014	-1000.0
EPO signaling pathway	7.0	426.0	55.0	-0.025	0.046	1000.0	-1000.0	-0.027	-1000.0
ceramide signaling pathway	7.0	360.0	49.0	-0.007	0.029	1000.0	-1000.0	-0.026	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	7.0	602.0	83.0	-0.056	0.046	1000.0	-1000.0	-0.023	-1000.0
Regulation of Telomerase	7.0	776.0	102.0	-0.02	0.099	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by PI3K	6.0	353.0	58.0	-0.014	0.077	1000.0	-1000.0	-0.031	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	300.0	45.0	-0.015	0.051	1000.0	-1000.0	-0.03	-1000.0
TCGA08_rtk_signaling	6.0	157.0	26.0	-0.013	0.047	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	528.0	76.0	-0.03	0.051	1000.0	-1000.0	-0.039	-1000.0
Arf6 trafficking events	6.0	475.0	71.0	-0.037	0.039	1000.0	-1000.0	-0.031	-1000.0
IGF1 pathway	6.0	378.0	57.0	-0.031	0.048	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in keratinocytes	6.0	265.0	43.0	-0.015	0.039	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	6.0	295.0	44.0	-0.005	0.063	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class I	5.0	552.0	104.0	-0.035	0.048	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	89.0	15.0	-0.017	0.022	1000.0	-1000.0	-0.017	-1000.0
S1P3 pathway	5.0	225.0	42.0	-0.022	0.035	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class II	4.0	355.0	75.0	-0.021	0.057	1000.0	-1000.0	-0.024	-1000.0
Circadian rhythm pathway	4.0	92.0	22.0	-0.004	0.046	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	4.0	195.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	282.0	68.0	-0.029	0.044	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	2.0	101.0	39.0	-0.016	0.042	1000.0	-1000.0	-0.017	-1000.0
Insulin-mediated glucose transport	2.0	65.0	32.0	-0.015	0.038	1000.0	-1000.0	-0.024	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	100.0	37.0	-0.023	0.05	1000.0	-1000.0	-0.018	-1000.0
TRAIL signaling pathway	2.0	133.0	48.0	-0.017	0.046	1000.0	-1000.0	-0.018	-1000.0
Rapid glucocorticoid signaling	2.0	46.0	20.0	-0.008	0.026	1000.0	-1000.0	-0.01	-1000.0
Arf1 pathway	2.0	129.0	54.0	-0.008	0.034	1000.0	-1000.0	-0.015	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	35.0	23.0	0.0	0.036	1000.0	-1000.0	-0.013	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.02	0.03	1000.0	-1000.0	0.016	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	62.0	36.0	-0.037	0.039	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	1.0	49.0	31.0	-0.017	0.029	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.019	0.039	1000.0	-1000.0	0.017	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	23.0	27.0	-0.018	0.045	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.056	1000.0	-1000.0	0.0	-1000.0
Total	3410	200741	7203	-9.53803153524	10.6102834983	131000	-131000	-3.55760070486	-131000