Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.175 0.347 -9999.0 0.0 -0.903 15.0 15.0 IHH -0.025 0.111 -9999.0 0.0 -0.596 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.091 0.198 -9999.0 0.0 -0.424 33.0 33.0 LRPAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.09 0.197 0.421 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.124 0.27 -9999.0 0.0 -0.713 18.0 18.0 SMO -0.139 0.284 -9999.0 0.0 -0.747 19.0 19.0 AKT1 -0.077 0.219 -9999.0 0.0 -0.896 7.0 7.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.117 -9999.0 0.0 -0.458 10.0 10.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.137 0.279 -9999.0 0.0 -0.73 19.0 19.0 STIL -0.071 0.2 -9999.0 0.0 -0.622 9.0 9.0 DHH N/PTCH2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.061 0.173 -9999.0 0.0 -0.491 4.0 4.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.302 0.543 -9999.0 0.0 -1.122 44.0 44.0 determination of left/right symmetry -0.137 0.279 -9999.0 0.0 -0.73 19.0 19.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 skeletal system development -0.296 0.532 -9999.0 0.0 -1.1 44.0 44.0 IHH N/Hhip -0.133 0.227 -9999.0 0.0 -0.448 50.0 50.0 DHH N/Hhip -0.1 0.198 -9999.0 0.0 -0.39 47.0 47.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.137 0.279 -9999.0 0.0 -0.73 19.0 19.0 pancreas development -0.154 0.266 -9999.0 0.0 -0.546 47.0 47.0 HHAT -0.035 0.184 -9999.0 0.0 -0.668 12.0 12.0 PI3K -0.03 0.143 -9999.0 0.0 -0.371 22.0 22.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.135 0.268 -9999.0 0.0 -0.587 39.0 39.0 somite specification -0.137 0.279 -9999.0 0.0 -0.73 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.075 0.2 -9999.0 0.0 -0.623 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.002 0.114 -9999.0 0.0 -0.378 13.0 13.0 SHH Np/Cholesterol/Megalin -0.025 0.144 -9999.0 0.0 -0.428 14.0 14.0 SHH -0.014 0.145 -9999.0 0.0 -0.492 13.0 13.0 catabolic process -0.08 0.195 -9999.0 0.0 -0.517 6.0 6.0 SMO/Vitamin D3 -0.11 0.254 -9999.0 0.0 -0.67 18.0 18.0 SHH Np/Cholesterol/Hhip -0.101 0.188 -9999.0 0.0 -0.411 31.0 31.0 LRP2 -0.023 0.138 -9999.0 0.0 -0.474 13.0 13.0 receptor-mediated endocytosis -0.103 0.245 -9999.0 0.0 -0.721 12.0 12.0 SHH Np/Cholesterol/BOC -0.019 0.127 -9999.0 0.0 -0.378 13.0 13.0 SHH Np/Cholesterol/CDO -0.01 0.126 -9999.0 0.0 -0.396 13.0 13.0 mesenchymal cell differentiation 0.1 0.186 0.408 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.072 0.202 -9999.0 0.0 -0.623 9.0 9.0 IHH N/PTCH2 0.005 0.066 -9999.0 0.0 -0.354 4.0 4.0 CDON 0.003 0.084 -9999.0 0.0 -0.458 5.0 5.0 IHH N/PTCH1 -0.08 0.197 -9999.0 0.0 -0.521 6.0 6.0 Megalin/LRPAP1 -0.003 0.1 -9999.0 0.0 -0.328 13.0 13.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.014 0.114 -9999.0 0.0 -0.389 13.0 13.0 PTCH1 -0.081 0.196 -9999.0 0.0 -0.518 6.0 6.0 HHIP -0.154 0.267 -9999.0 0.0 -0.547 47.0 47.0