E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.103 -9999.0 0.0 -0.29 29.0 29.0 KLHL20 -0.007 0.091 0.172 1.0 -0.247 17.0 18.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.012 0.079 0.267 3.0 -0.28 3.0 6.0 ENAH -0.013 0.104 -9999.0 0.0 -0.289 30.0 30.0 AP1M1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.047 -9999.0 0.0 -0.217 4.0 4.0 ABI1/Sra1/Nap1 -0.024 0.051 -9999.0 0.0 -0.167 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.285 9.0 9.0 RAPGEF1 -0.005 0.096 0.274 3.0 -0.334 8.0 11.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.11 -9999.0 0.0 -0.293 31.0 31.0 CRK -0.004 0.092 -9999.0 0.0 -0.334 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 alphaE/beta7 Integrin 0.033 0.055 -9999.0 0.0 -0.352 5.0 5.0 IQGAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.029 -9999.0 0.0 -0.276 1.0 1.0 DLG1 -0.009 0.095 -9999.0 0.0 -0.289 25.0 25.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.033 -9999.0 0.0 -0.49 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.039 -9999.0 0.0 -0.277 3.0 3.0 PI3K -0.001 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.051 -9999.0 0.0 -0.356 4.0 4.0 TIAM1 0.022 0.056 -9999.0 0.0 -0.49 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.048 -9999.0 0.0 -0.263 4.0 4.0 AKT1 0.004 0.04 0.161 2.0 -9999.0 0.0 2.0 PIK3R1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.018 0.064 -9999.0 0.0 -0.49 4.0 4.0 RhoA/GDP 0.015 0.081 0.267 3.0 -0.277 3.0 6.0 actin cytoskeleton organization -0.003 0.068 0.142 1.0 -0.178 17.0 18.0 CDC42/GDP 0.015 0.081 0.267 3.0 -0.277 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.014 0.035 -9999.0 0.0 -0.238 4.0 4.0 ITGB7 0.019 0.072 -9999.0 0.0 -0.49 5.0 5.0 RAC1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.059 0.051 -9999.0 0.0 -0.28 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.043 -9999.0 0.0 -0.26 4.0 4.0 mol:GDP -0.0 0.085 0.271 3.0 -0.317 3.0 6.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.024 0.084 0.264 3.0 -0.284 3.0 6.0 RAC1/GTP/IQGAP1 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.01 0.075 0.128 2.0 -0.207 27.0 29.0 NME1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.097 -9999.0 0.0 -0.29 25.0 25.0 regulation of cell-cell adhesion 0.006 0.035 -9999.0 0.0 -0.192 4.0 4.0 WASF2 -0.001 0.035 -9999.0 0.0 -0.123 3.0 3.0 Rap1/GTP 0.02 0.058 0.273 2.0 -0.239 4.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.071 -9999.0 0.0 -0.271 9.0 9.0 CCND1 -0.014 0.092 0.146 2.0 -0.259 27.0 29.0 VAV2 -0.015 0.173 -9999.0 0.0 -0.601 15.0 15.0 RAP1/GDP 0.023 0.067 0.289 2.0 -0.243 3.0 5.0 adherens junction assembly -0.007 0.094 -9999.0 0.0 -0.282 25.0 25.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.043 0.064 -9999.0 0.0 -0.263 9.0 9.0 E-cadherin/beta catenin 0.006 0.038 -9999.0 0.0 -0.277 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.01 0.102 -9999.0 0.0 -0.292 28.0 28.0 PIK3CA 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.044 0.13 -9999.0 0.0 -0.349 30.0 30.0 E-cadherin/beta catenin/alpha catenin 0.045 0.05 -9999.0 0.0 -0.305 4.0 4.0 ITGAE 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.005 0.112 -9999.0 0.0 -0.299 31.0 31.0