E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.046 0.101 -9999.0 0.0 -0.325 61.0 61.0 KLHL20 -0.058 0.078 0.474 1.0 -0.258 25.0 26.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.23 6.0 -0.253 17.0 23.0 ENAH -0.047 0.102 -9999.0 0.0 -0.322 63.0 63.0 AP1M1 0.026 0.009 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 RAP1A 0.029 0.004 -9999.0 0.0 -0.003 9.0 9.0 CTNNB1 0.027 0.01 -9999.0 0.0 -0.019 24.0 24.0 CDC42/GTP -0.058 0.05 0.116 22.0 -0.233 2.0 24.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.171 33.0 33.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.046 -9999.0 0.0 -0.141 8.0 8.0 RAPGEF1 -0.046 0.098 0.249 3.0 -0.308 53.0 56.0 CTNND1 0.029 0.004 -9999.0 0.0 -0.005 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.112 -9999.0 0.0 -0.324 65.0 65.0 CRK -0.045 0.101 -9999.0 0.0 -0.318 58.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.042 -9999.0 0.0 -0.156 18.0 18.0 alphaE/beta7 Integrin 0.04 0.014 -9999.0 0.0 -0.162 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.039 0.042 -9999.0 0.0 -0.13 21.0 21.0 DLG1 -0.032 0.102 0.193 1.0 -0.325 51.0 52.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.148 15.0 15.0 MLLT4 0.025 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.047 0.024 -9999.0 0.0 -0.129 1.0 1.0 PI3K -0.053 0.054 -9999.0 0.0 -0.192 12.0 12.0 ARF6 0.028 0.006 -9999.0 0.0 -0.006 14.0 14.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.175 18.0 18.0 TIAM1 0.028 0.008 -9999.0 0.0 -0.004 27.0 27.0 E-cadherin(dimer)/Ca2+ 0.052 0.041 -9999.0 0.0 -0.131 7.0 7.0 AKT1 -0.012 0.069 0.142 40.0 -9999.0 0.0 40.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.024 0.013 -9999.0 0.0 -0.005 85.0 85.0 RhoA/GDP -0.043 0.08 0.231 6.0 -0.257 14.0 20.0 actin cytoskeleton organization -0.043 0.059 0.411 1.0 -0.199 16.0 17.0 CDC42/GDP -0.043 0.08 0.231 6.0 -0.252 17.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.056 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.003 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.003 29.0 29.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.044 -9999.0 0.0 -0.141 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.031 -9999.0 0.0 -0.121 7.0 7.0 mol:GDP -0.042 0.084 0.233 6.0 -0.276 20.0 26.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.132 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.046 0.083 0.238 6.0 -0.26 15.0 21.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.132 2.0 2.0 PIP5K1C/AP1M1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.028 0.005 -9999.0 0.0 -0.002 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.045 0.057 0.092 3.0 -0.13 140.0 143.0 NME1 0.027 0.008 -9999.0 0.0 -0.001 44.0 44.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.324 65.0 65.0 regulation of cell-cell adhesion -0.053 0.041 0.082 21.0 -0.206 2.0 23.0 WASF2 -0.03 0.035 0.096 5.0 -0.105 35.0 40.0 Rap1/GTP -0.054 0.058 0.251 2.0 -0.251 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.062 -9999.0 0.0 -0.151 18.0 18.0 CCND1 -0.054 0.069 0.112 2.0 -0.158 142.0 144.0 VAV2 -0.039 0.165 -9999.0 0.0 -0.66 24.0 24.0 RAP1/GDP -0.045 0.067 0.242 4.0 -0.253 3.0 7.0 adherens junction assembly -0.046 0.101 -9999.0 0.0 -0.315 65.0 65.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.227 2.0 6.0 E-cadherin/beta catenin -0.021 0.045 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.045 0.1 -9999.0 0.0 -0.327 59.0 59.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.089 0.112 0.567 1.0 -0.39 36.0 37.0 E-cadherin/beta catenin/alpha catenin 0.048 0.03 -9999.0 0.0 -0.145 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.114 -9999.0 0.0 -0.33 65.0 65.0