Clinical Features CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q 1p gain 8 (9%) 83 0.5564 1 0.1624 1 0.59393 1 0.31098 1 0.45684 1 0.40389 1 0.26535 1 0.52503 1 1q gain 24 (26%) 67 0.0075164 1 0.025413 1 0.45234 1 0.068132 1 0.36212 1 0.28235 1 0.052693 1 0.16869 1 2p gain 6 (7%) 85 0.13638 1 0.083777 1 0.18561 1 0.012648 1 0.62769 1 0.41016 1 0.66167 1 0.19186 1 2q gain 7 (8%) 84 0.4479 1 0.36604 1 0.59393 1 0.0071886 1 0.74417 1 0.8816 1 1 1 0.52503 1 3p gain 5 (5%) 86 0.13335 1 0.066774 1 0.70692 1 0.66713 1 0.086453 1 1 1 0.43303 1 1 1 3q gain 10 (11%) 81 0.014126 1 0.011646 1 0.42273 1 0.19132 1 0.81705 1 0.33612 1 0.69123 1 0.31355 1 5p gain 12 (13%) 79 0.0053242 1 0.039013 1 0.43673 1 0.31025 1 0.7689 1 1 1 0.33978 1 0.67099 1 5q gain 8 (9%) 83 0.12046 1 0.1624 1 0.56343 1 0.73203 1 0.8432 1 0.89544 1 1 1 1 1 7p gain 25 (27%) 66 0.0029538 1 0.00055016 0.295 0.036877 1 0.00077234 0.412 0.03395 1 0.010229 1 0.016922 1 0.0028533 1 7q gain 22 (24%) 69 0.0033248 1 0.0038968 1 0.13838 1 0.0044931 1 0.13148 1 0.023468 1 0.040622 1 0.018204 1 8p gain 13 (14%) 78 0.0058598 1 0.039013 1 0.78249 1 0.051019 1 0.7689 1 0.47341 1 0.72056 1 0.43966 1 8q gain 24 (26%) 67 0.0018499 0.967 0.0010977 0.581 0.22788 1 0.0014122 0.743 0.26049 1 0.18098 1 0.039771 1 0.040548 1 9p gain 3 (3%) 88 0.069095 1 0.36125 1 0.60203 1 0.31483 1 0.57803 1 0.30453 1 0.45603 1 0.32362 1 9q gain 3 (3%) 88 0.069095 1 0.36125 1 0.60203 1 0.31483 1 0.57803 1 0.30453 1 0.45603 1 0.32362 1 10p gain 4 (4%) 87 0.055748 1 0.18169 1 0.32245 1 0.31483 1 0.26186 1 1 1 0.59621 1 0.32362 1 10q gain 6 (7%) 85 0.016557 1 0.022997 1 0.18331 1 0.32537 1 0.13191 1 0.53201 1 0.34489 1 0.14528 1 11p gain 9 (10%) 82 0.011518 1 0.015649 1 0.43392 1 0.52928 1 0.44951 1 0.65697 1 0.81787 1 0.38944 1 11q gain 7 (8%) 84 0.077772 1 0.32342 1 0.77423 1 0.31098 1 0.77902 1 0.8816 1 0.88821 1 0.52503 1 12p gain 10 (11%) 81 1.4577e-06 0.000819 0.013014 1 0.73269 1 0.025723 1 0.75361 1 0.30898 1 0.47332 1 0.16006 1 12q gain 7 (8%) 84 0.00021803 0.12 0.053647 1 0.30326 1 0.1219 1 0.62753 1 0.46309 1 0.52314 1 0.26591 1 13q gain 9 (10%) 82 1 1 0.45596 1 0.34682 1 0.51488 1 0.17769 1 0.053528 1 0.4472 1 0.40035 1 14q gain 10 (11%) 81 0.014126 1 0.33468 1 0.75699 1 0.76799 1 0.079565 1 0.91085 1 0.63061 1 1 1 15q gain 7 (8%) 84 0.50776 1 0.37473 1 0.46877 1 0.44591 1 0.88428 1 0.48777 1 0.075067 1 0.4124 1 16p gain 10 (11%) 81 0.00015431 0.0853 0.0047575 1 0.3847 1 0.19132 1 0.46231 1 0.12003 1 0.25223 1 0.055384 1 16q gain 11 (12%) 80 0.00022743 0.125 0.002215 1 0.45047 1 0.1047 1 0.036243 1 0.19086 1 0.14927 1 0.025154 1 17q gain 4 (4%) 87 0.055748 1 0.13146 1 0.45706 1 0.32537 1 0.6241 1 0.10394 1 0.68175 1 0.14528 1 18p gain 13 (14%) 78 0.00048971 0.265 0.00019093 0.105 0.037176 1 0.0047224 1 0.11404 1 0.0014005 0.739 0.0019382 1 0.0021151 1 18q gain 4 (4%) 87 0.055748 1 0.36125 1 0.60203 1 0.31483 1 0.86401 1 0.30453 1 0.79541 1 0.32362 1 19p gain 4 (4%) 87 0.3426 1 0.67389 1 0.80596 1 1 1 0.29925 1 0.53201 1 0.34489 1 0.56412 1 19q gain 12 (13%) 79 0.058073 1 0.18825 1 0.3371 1 0.58927 1 0.3044 1 0.51586 1 0.14137 1 0.43966 1 20p gain 15 (16%) 76 0.0014081 0.742 0.011394 1 0.092011 1 0.10176 1 0.91128 1 0.26158 1 0.70078 1 0.12143 1 20q gain 20 (22%) 71 9.8449e-06 0.00548 0.046621 1 0.22258 1 0.074807 1 0.69806 1 0.27677 1 0.31997 1 0.1315 1 22q gain 6 (7%) 85 0.13638 1 0.0048332 1 0.30358 1 0.20221 1 0.85834 1 0.2734 1 0.84814 1 0.36858 1 xq gain 3 (3%) 88 1 1 1 1 0.081063 1 0.56859 1 0.66392 1 0.092565 1 0.45603 1 0.091096 1 1p loss 15 (16%) 76 0.014702 1 0.00047228 0.256 0.050144 1 0.0069076 1 0.62409 1 0.082652 1 0.11285 1 0.3162 1 1q loss 4 (4%) 87 0.3426 1 0.06152 1 0.7985 1 0.31483 1 1 1 0.59227 1 0.15752 1 0.79262 1 2p loss 7 (8%) 84 0.038566 1 0.12177 1 0.59393 1 0.73133 1 0.68394 1 0.40389 1 0.88821 1 0.52503 1 2q loss 3 (3%) 88 0.069095 1 0.36125 1 0.32245 1 0.31483 1 0.86401 1 0.30453 1 0.79541 1 0.32362 1 3p loss 14 (15%) 77 0.0048723 1 0.097821 1 0.85696 1 0.4533 1 0.8058 1 0.54025 1 0.20558 1 0.16415 1 3q loss 10 (11%) 81 0.14414 1 0.12379 1 0.73269 1 0.52928 1 0.64345 1 0.90094 1 0.13936 1 0.4786 1 4p loss 12 (13%) 79 0.10088 1 0.049709 1 0.079348 1 0.30199 1 0.20372 1 0.48776 1 0.4589 1 0.14793 1 4q loss 11 (12%) 80 0.18381 1 0.0042921 1 0.04115 1 0.39025 1 0.20514 1 0.46103 1 0.5706 1 0.049628 1 5p loss 4 (4%) 87 0.055748 1 0.18169 1 0.18331 1 0.32537 1 0.13191 1 0.10394 1 0.14191 1 0.14528 1 5q loss 8 (9%) 83 0.00036857 0.2 0.024195 1 0.081754 1 0.060182 1 0.49461 1 0.038075 1 0.0044853 1 0.044187 1 6p loss 32 (35%) 59 0.00075374 0.402 7.943e-05 0.0442 0.30156 1 0.00030331 0.165 0.16401 1 0.17801 1 0.013735 1 0.011827 1 6q loss 41 (45%) 50 8.127e-06 0.00454 3.8725e-07 0.000219 0.002169 1 8.1485e-07 0.00046 0.0045229 1 0.0010598 0.562 0.00056192 0.301 0.00051861 0.28 8p loss 13 (14%) 78 0.28102 1 0.029685 1 0.011932 1 0.051019 1 0.16255 1 0.015533 1 0.040751 1 0.0046319 1 8q loss 3 (3%) 88 0.19632 1 0.18403 1 0.32245 1 0.31483 1 0.57803 1 1 1 0.79541 1 0.60079 1 9p loss 36 (40%) 55 0.0031066 1 0.023489 1 0.034529 1 0.55294 1 0.23543 1 0.10208 1 0.032431 1 0.14245 1 9q loss 24 (26%) 67 0.081625 1 0.27381 1 0.72311 1 1 1 0.23838 1 0.7833 1 0.18695 1 0.68142 1 10p loss 15 (16%) 76 0.0027876 1 0.085514 1 0.49496 1 0.029265 1 0.44608 1 0.042997 1 0.077472 1 0.22376 1 10q loss 15 (16%) 76 0.00015416 0.0853 0.067614 1 0.48329 1 0.011224 1 0.80447 1 0.0081692 1 0.19815 1 0.10034 1 11p loss 8 (9%) 83 0.027845 1 0.65622 1 0.19897 1 1 1 0.074508 1 0.35481 1 0.093158 1 0.2299 1 11q loss 10 (11%) 81 0.14414 1 0.63933 1 0.48668 1 1 1 1 1 1 1 0.47332 1 1 1 12p loss 10 (11%) 81 0.011714 1 0.011646 1 0.026615 1 0.025723 1 0.047841 1 0.078204 1 0.47332 1 0.01335 1 12q loss 13 (14%) 78 0.00027517 0.151 0.002044 1 0.64264 1 0.1047 1 0.74804 1 0.061889 1 0.41812 1 0.16504 1 13q loss 11 (12%) 80 0.00028202 0.154 0.30829 1 0.062798 1 0.19132 1 0.30111 1 0.056363 1 0.30887 1 0.070749 1 14q loss 7 (8%) 84 0.88315 1 0.0074978 1 0.22657 1 0.73133 1 0.4192 1 0.52259 1 0.31302 1 0.11275 1 15q loss 15 (16%) 76 0.0002509 0.137 0.0001455 0.0806 0.022754 1 0.00055899 0.3 0.0015353 0.806 0.0053389 1 0.062117 1 8.7795e-05 0.0487 16p loss 3 (3%) 88 0.027608 1 0.36125 1 0.7985 1 0.31483 1 0.26186 1 1 1 0.31604 1 0.32362 1 16q loss 3 (3%) 88 0.1168 1 0.18403 1 0.32245 1 0.31483 1 0.86401 1 0.30453 1 0.31604 1 0.32362 1 17p loss 37 (41%) 54 1.3811e-11 7.84e-09 4.2634e-11 2.42e-08 0.00053021 0.285 4.2153e-06 0.00236 9.1967e-07 0.000519 0.0005163 0.279 1.1951e-06 0.000673 8.9579e-06 0.005 17q loss 12 (13%) 79 0.00095992 0.51 0.039013 1 0.61726 1 0.39025 1 0.46231 1 0.62597 1 0.27839 1 0.51948 1 18p loss 32 (35%) 59 0.80642 1 0.099298 1 0.23339 1 0.68011 1 0.35882 1 0.080111 1 0.31131 1 0.38672 1 18q loss 52 (57%) 39 0.0048095 1 0.0016043 0.841 0.39882 1 0.10374 1 0.036203 1 0.76078 1 0.09675 1 0.24153 1 19p loss 11 (12%) 80 0.00089086 0.474 0.079279 1 0.034301 1 0.0094224 1 0.47923 1 0.061889 1 0.21406 1 0.38269 1 19q loss 6 (7%) 85 0.10705 1 0.567 1 0.041815 1 0.14506 1 0.26703 1 0.014677 1 0.47269 1 0.10595 1 20p loss 9 (10%) 82 0.024908 1 0.078582 1 0.16429 1 0.31948 1 0.023685 1 0.39859 1 0.035048 1 0.27382 1 21q loss 32 (35%) 59 2.4365e-06 0.00137 0.0049596 1 0.019355 1 0.0055685 1 0.032318 1 0.087431 1 0.020657 1 0.10529 1 22q loss 20 (22%) 71 0.005673 1 0.022331 1 0.13387 1 0.12408 1 0.0803 1 0.22818 1 0.068642 1 0.34724 1 xq loss 9 (10%) 82 0.0003569 0.194 0.19333 1 0.26942 1 0.73203 1 0.090935 1 0.31628 1 0.070137 1 0.27382 1